scholarly journals The olfactory receptor gene OR56A4 is differentially expressed based on disease stage in breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Olfactory Receptor ◽  
Expression Profiles ◽  
Receptor Gene ◽  
Gene Expression Profiles ◽  
Stage I ◽  
Stage Iii ◽  
Disease Stage ◽  
Primary Tumors

To understand the transcriptional behavior that accompanies breast cancer progression, we compared the global gene expression profiles of 100 tumors at stages I, II and III using two independent published microarray datasets (1, 2). We found that the olfactory receptor, family 56, subfamily A, member 4 OR56A4 was among the genes whose expression was most different when comparing stage I, stage II, and stage III primary tumors from patients with breast cancer. OR56A4 expression was lower in stage III tumors as opposed to stage I tumors.

Differing from diseased stage in melanoma, the olfactory receptor gene OR56A4 is expressed

2021 ◽  
Author(s):  
Bronte Morse ◽  
Kobi Decker
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Olfactory Receptor ◽  
Receptor Gene ◽  
Stage I ◽  
Stage Ii ◽  
Stage Iii ◽  
Olfactory Receptor Gene ◽  
Breast Cancer Patients ◽  
Receptor Family

We have compared the global profiles of 100 tumors in Stage I, II and III with two independently releasedmicroarray datasets in order to understand their transcriptional behaviors accompanying a progression in breastcancer (1, 2). The olfactive receptor, family 56, subfamily A, member 4 OR56A4, was discovered to have beenone of the genes with the most varied expression when comparing initial tumors in stage I, stage II, and stageIII of breast cancer patients. In the stage III tumors, OR56A4 expression in comparison to the stage I tumorswas lower.

scholarly journals Mediterranean fever (PYRIN) is differentially expressed and up-regulated in the bone metastases of patients with metastatic breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Survival Data ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Metastatic Breast ◽  
Secretion Systems ◽  
Primary Tumors ◽  
Mediterranean Fever

To understand the transcriptional nature of metastasis to disparate sites in human breast cancer, we mined published microarray data (1), comparing global gene expression profiles of metastasis to the bones and to the lymph nodes. We discovered that the pattern recognition receptor PYRIN, also known as Mediterranean fever (MEFV), was among the genes whose expression was most different, transcriptome-wide, in bone and lymph node metastases. PYRIN mRNA was present at significantly higher quantities in metastasis to the bone as compared to metastasis to the lymph nodes. Analysis of patient survival data revealed that expression of PYRIN in primary tumors of the breast was correlated with distant metastasis-free survival, in lymph node positive patients but not in lymph node negative patients. PYRIN has functions in innate immune sensing of modifications of RhoGTP and the cytoskeleton by bacterial Type III secretion systems (2, 3) and is modulated by Yersinia pestis (4, 5).

Gene expression profiles of circulating tumor cells versus primary tumors in metastatic breast cancer

2015 ◽  
Vol 362 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Wendy Onstenk ◽  
Anieta M. Sieuwerts ◽  
Marleen Weekhout ◽  
Bianca Mostert ◽  
Esther A. Reijm ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Metastatic Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Metastatic Breast ◽  
Primary Tumors

scholarly journals BIRC5 is differentially expressed in epithelial ovarian cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Progression ◽  
Expression Profiles ◽  
Gynecologic Cancer ◽  
Gene Expression Profiles ◽  
Ovarian Tumors ◽  
Normal Ovary ◽  
Primary Tumors ◽  
Ovarian Cancers

Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We sought to identify genes associated with epithelial ovarian cancer and the high-grade serous ovarian cancer (HGSC) subtype by comparing global gene expression profiles of normal ovary with that of primary tumors from women diagnosed with epithelial cancer and HGSC in specific using published microarray data (2, 3). We identified the gene encoding the baculoviral inhibitor of apoptosis repeat (IAP) containing 5, BIRC5 as among the genes whose expression was most different in epithelial ovarian cancer and in HGSC ovarian tumors. BIRC5 expression was significantly higher in ovarian tumors relative to normal ovary. Correlation of BIRC5 expression with survival outcomes in patients with ovarian cancer was complex, with low expression favorable early in disease and high expression favorable later in disease. These data indicate that expression of BIRC5 is perturbed in epithelial ovarian cancers broadly and in ovarian cancers of the HGSC subtype. BIRC5 may be relevant to pathways underlying ovarian cancer progression.

scholarly journals Sociodemographic Factors Associated With Rapid Relapse in Triple-Negative Breast Cancer: A Multi-Institution Study

2021 ◽  
Vol 19 (7) ◽  
pp. 797-804
Author(s):  
Sarah Asad ◽  
Carlos H. Barcenas ◽  
Richard J. Bleicher ◽  
Adam L. Cohen ◽  
Sara H. Javid ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Stage I ◽  
Age At Diagnosis ◽  
Stage Iii ◽  
Disease Stage ◽  
Multivariable Model ◽  
Insurance Type ◽  
Final Multivariable Model

Background: Triple-negative breast cancer (TNBC) accounts for disproportionately poor outcomes in breast cancer, driven by a subset of rapid-relapse TNBC (rrTNBC) with marked chemoresistance, rapid metastatic spread, and poor survival. Our objective was to evaluate clinicopathologic and sociodemographic features associated with rrTNBC. Methods: We included patients diagnosed with stage I–III TNBC in 1996 through 2012 who received chemotherapy at 1 of 10 academic cancer centers. rrTNBC was defined as a distant metastatic recurrence event or death ≤24 months after diagnosis. Features associated with rrTNBC were included in a multivariable logistic model upon which backward elimination was performed with a P<.10 criterion, with a final multivariable model applied to training (70%) and independent validation (30%) cohorts. Results: Among all patients with breast cancer treated at these centers, 3,016 fit the inclusion criteria. Training cohort (n=2,112) bivariable analyses identified disease stage, insurance type, age, body mass index, race, and income as being associated with rrTNBC (P<.10). In the final multivariable model, rrTNBC was significantly associated with higher disease stage (adjusted odds ratio for stage III vs I, 16.0; 95% CI, 9.8–26.2; P<.0001), Medicaid/indigent insurance, lower income (by 2000 US Census tract), and younger age at diagnosis. Model performance was consistent between the training and validation cohorts. In sensitivity analyses, insurance type, low income, and young age were associated with rrTNBC among patients with stage I/II but not stage III disease. When comparing rrTNBC versus late relapse (>24 months), we found that insurance type and young age remained significant. Conclusions: Timing of relapse in TNBC is associated with stage of disease and distinct sociodemographic features, including insurance type, income, and age at diagnosis.

scholarly journals Gene expression profiles of human breast cancer progression

2003 ◽  
Vol 100 (10) ◽  
pp. 5974-5979 ◽  
Author(s):  
X.-J. Ma ◽  
R. Salunga ◽  
J. T. Tuggle ◽  
J. Gaudet ◽  
E. Enright ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Breast Cancer Progression ◽  
Human Breast

scholarly journals Analysis of gene expression patterns in triple negative breast cancer: MERTK and WHSC1L1.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Black Women ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Molecular Subtype ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Gene Expression Profiles ◽  
Primary Tumors

Triple negative breast cancer (TNBC) shares overlap with the basal molecular subtype of breast cancer and is more frequently diagnosed in African-American (black) women for reasons not understood (1,2). To understand genes whose expression may be of pertinence to the development or progression of triple negative breast cancer, we mined published microarray data (3,4) comparing global gene expression profiles of TNBC histology groups, identifying genes whose expression changed the least between among TNBCs, suggesting that these genes may be important for TNBC biology. We identified the MER proto-oncogene tyrosine kinase MERTK and the Wolf-Hirschhorn syndrome candidate 1-like 1 WHSC1L1 among the genes whose expression differed the least when comparing TNBC cases and subtypes. In another dataset, MERTK and WHSCL1 were found to be differentially expressed in TNBC when comparing primary tumors of the breast to normal breast tissue. Kaplan-Meier survival analysis revealed that expression levels of MERTK and WHSCL1 correlated with survival outcomes in human breast cancer, and that this correlation differed based on race of the patient. MERTK and WHSCL1 may be of relevance in understanding the etiology or progression of triple negative breast cancer.

Gene expression profiles of primary tumors versus circulating tumor cells in metastatic breast cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 11017-11017
Author(s):  
Wendy Onstenk ◽  
Anieta M. Sieuwerts ◽  
Marleen Weekhout ◽  
Bianca Mostert ◽  
Esther Anneke Reijm ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Metastatic Breast Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Metastatic Breast ◽  
Primary Tumors

scholarly journals The accessory protein of the IL-18 receptor, IL-18 RAP, is differentially expressed and up-regulated in the bone metastases of patients with metastatic breast cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Survival Data ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Metastatic Breast ◽  
Accessory Protein ◽  
Primary Tumors

To understand the transcriptional nature of metastasis to disparate sites in human breast cancer, we mined published microarray data (1, 2), comparing global gene expression profiles of metastasis to the bones and to the lymph nodes. We discovered that the IL-18 receptor accessory protein, encoded by IL18RAP, was among the genes whose expression was most different, transcriptome-wide, in bone and lymph node metastases. IL18RAP mRNA was present at significantly higher quantities in metastasis to the bone as compared to metastasis to the lymph nodes. Analysis of patient survival data revealed that expression of IL18RAP in primary tumors of the breast was correlated with overall survival, in lymph node negative patients but not in lymph node positive patients. Signal transduction through the IL-18 receptor may be important in understanding basic differences between the transcriptional composition of metastasis to the lymph nodes and to the bones in humans with metastatic breast cancer.

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