scholarly journals Non-Invasive Treatment of Pediatric Neurological Disorders using MR-guided Focused Ultrasound - Part 1 Pediatric Skull Characterization and Re-Focusing

2018 ◽  
Author(s):  
James Drake
Keyword(s):  
Focused Ultrasound ◽  
Pediatric Patients ◽  
Current Treatment ◽  
Acoustic Properties ◽  
Invasive Treatment ◽  
Non Invasive ◽  
Treatment Techniques ◽  
Early Results ◽  
Intracerebral Hemorrhages ◽  
Surrounding Areas

The concept of brain lesioning is well established in adult tremor and early results from MRgFUS trials have shown great efficiacy. In addition, work has been done to show that is possible to target and ablate tumors with transcranial systems. However, there is little to no work performed on neonatal and pediatric patients. Based on clinical presentation of IVH and epilepsy, there is a clear clinical need for non-invasive treatments as current treatment techniques have complications (eg. secondary intracerebral hemorrhages from tPA). With our initial data, neonatal and pediatric patients possess unique skull and brain properties that facilitate and simplify the transmission of focused ultrasound. The open fontanelle and thinner skulls potentially reduce the need for lower frequencies which opens up the possibility of using existing MRgFUS transducers to perform the treatment and reduce the upfront investments. Our project will characterize the acoustic properties of pediatric skulls over 3 frequencies, develop a refocusing algorithm based on the acoustic data, simulate the acoustic transmission through the skull to study the effects on the target and surrounding areas and validate the algorithm on a porcine model.

scholarly journals Updated Costs of Uterine Fibroid Treatments Including Focused Ultrasound Surgery

2018 ◽  
Author(s):  
Bijan J. Borah ◽  
Elizabeth A. Stewart
Keyword(s):  
Magnetic Resonance ◽  
Focused Ultrasound ◽  
Treatment Options ◽  
Uterine Fibroids ◽  
Reproductive Age ◽  
Invasive Treatment ◽  
Ultrasound Surgery ◽  
Non Invasive ◽  
Focused Ultrasound Surgery ◽  
Reproductive Age Women

Uterine leiomyomas (fibroids) affect 20–40% of reproductive age women and are the major indication for hysterectomy. Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a new, potentially disruptive, non-invasive and uterine-sparing treatment option that has been shown to yield similar or better clinical outcomes than other uterine-sparing interventions. However, the costs of MRgFUS and other minimally-invasive treatment options have not been studied using US practice data. This study attempts to fill this void. And since uterine fibroids are the first FDA-approved indication for MRgFUS treatment, this study may also have implications for other indications which are now investigational.

scholarly journals Superficial malignant tumors: Non-invasive treatment with ultrasonographically guided high-intensity focused ultrasound

2009 ◽  
Vol 8 (24) ◽  
pp. 2398-2405 ◽  
Author(s):  
Chuanxing Li ◽  
Weidong Zhang ◽  
Rong Zhang ◽  
Ming Zhao ◽  
Zilin Huang ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
Malignant Tumors ◽  
High Intensity Focused Ultrasound ◽  
Invasive Treatment ◽  
Non Invasive

High-intensity focused ultrasound in breast pathology: non-invasive treatment of benign and malignant lesions

2014 ◽  
Vol 12 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Beatrice Cavallo Marincola ◽  
Federica Pediconi ◽  
Michele Anzidei ◽  
Elena Miglio ◽  
Luisa Di Mare ◽  
...  
Keyword(s):  
High Intensity ◽  
Focused Ultrasound ◽  
High Intensity Focused Ultrasound ◽  
Invasive Treatment ◽  
Breast Pathology ◽  
Non Invasive ◽  
Malignant Lesions

scholarly journals Management of pericoronitis for partial eruption of second permanent molar in a pediatric patient

2021 ◽  
Vol 54 (4) ◽  
pp. 169
Author(s):  
Tengku Natasha Eleena Binti Tengku Ahmad Noor ◽  
James Lian Yoon Chen ◽  
Mohd Safwani Affan Alli ◽  
Mohd Hosni Bin Mahmood
Keyword(s):  
Pediatric Patient ◽  
Pediatric Patients ◽  
Armed Forces ◽  
Systematic Desensitization ◽  
Invasive Treatment ◽  
Dental Services ◽  
Local Scaling ◽  
Second Molar ◽  
Non Invasive ◽  
Permanent Molar

Background: This article discussed the management of pericoronitis for partial eruption of molar on pediatric patients. Purpose: This case report was to discuss how to manage a pediatric patient with a partially erupted second molar by using an electrosurgery method as the last alternative; also, it assessed whether or not the treatment facilitates spontaneous tooth eruption in respect to incomplete treatments. Case: A 9-years-old girl visited the Kuching Armed Forces Dental Clinic with her parents and complained of recurrent swelling on her lower right jaw in the last six months and noticed a tooth-like white lump under it. After a deliberate examination, the dentists came up with a diagnosis of pericoronitis because of a partially erupted second molar. Case Management: In managing a pediatric patient, a systematic desensitization was performed whereby the first visit was more of non-invasive treatment such as oral health instructions, a proper tooth brushing technique, and local scaling and debridement. Operculectomy using the electrosurgery had been carried out in the fourth visit and reviewed after one-week treatment that shows uneventful healing. Conclusion: To prevent and treat oral problems, it is imperative to develop child’s interest and willingness in using dental services. Hence, an early diagnosis is critical, especially as parents seek for the best treatment duration and treatment methods with the least number of consequences. The food impaction and the recurrent swelling because of pericoronitis have a major impact on the patient; therefore, treatment is provided regardless of patient’s age.

Applications of Micro/Nanotechnology in Ultrasound-Based Drug Delivery and Therapy for Tumors

2020 ◽  
Vol 27 ◽  
Author(s):  
Suhui Sun ◽  
Ping Wang ◽  
Sujuan Sun ◽  
Xiaolong Liang
Keyword(s):  
Drug Delivery ◽  
Focused Ultrasound ◽  
Tumor Therapy ◽  
High Intensity Focused Ultrasound ◽  
Nano Materials ◽  
Invasive Treatment ◽  
Sonodynamic Therapy ◽  
Non Invasive ◽  
Recent Developments

: Ultrasound has been broadly used in biomedicine for both tumor diagnosis as well as therapy. The applications of recent developments in micro/nanotechnology promote the development of ultrasound-based biomedicine, especially in the field of ultrasound-based drug delivery and tumor therapy. Ultrasound can activate nano-sized drug delivery systems by different mechanisms for ultrasound-triggered on-demand drug release targeted only at the tumor. Ultrasound targeted microbubble destruction (UTMD) technology can not only increase the permeability of vasculature and cell membrane via sonoporation effect but also achieve in situ conversion of microbubbles into nanoparticles to promote cellular uptake and therapeutic efficacy. Furthermore, high intensity focused ultrasound (HIFU), or sonodynamic therapy (SDT), is considered to be one of the most promising and representative non-invasive treatment for cancer. However, their application in the treatment process is still limited due to their critical treatment efficiency issues. Fortunately, recently developed micro/nanotechnology offer an opportunity to solve these problems, thus improving the therapeutic effect of cancer. This review summarizes and discusses the recent developments in the design of micro- and nano- materials for ultrasound-based biomedicine applications.

A feasibility study for the non-invasive treatment of superficial bladder tumours with focused ultrasound

1996 ◽  
Vol 78 (5) ◽  
pp. 715-721 ◽  
Author(s):  
N.A. Watkin ◽  
S.B. Morris ◽  
I.H. Rivens ◽  
C.R.J. Woodhouse
Keyword(s):  
Feasibility Study ◽  
Focused Ultrasound ◽  
Invasive Treatment ◽  
Non Invasive ◽  
Bladder Tumours
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