scholarly journals Role of tranexamic acid to reduce blood loss and transfusion of allogeneic blood in the field of surgery

2020 ◽  
Vol 11 (2) ◽  
pp. 89-95
Author(s):  
Indra K. Shrestha ◽  
Yong Yu Si ◽  
Jian Ping Tao
Keyword(s):  
Adverse Effects ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Allogeneic Blood ◽  
Reduce Blood Loss ◽  
Acute Bleeding ◽  
Postoperative Time ◽  
Scope Of Application ◽  
Time Periods

Tranexamic acid is widely used as an antifibrinolytic drug to reduce blood loss intraoperative and postoperative time periods as well as to reduce transfusion of allogeneic blood. After releasing in the market, multidisciplinary surgeries have wide use of tranexamic acid due to its antifibrinolytic effect to reduce bleeding and transfusion of blood. In literature, there were mentioned a few adverse effects like thromboembolism, seizure, anaphylactic reaction, etc which are still unsolved questions to date. The aim of this review to minimize the blood loss from acute bleeding in different situations by updating the doses used in a different clinical scenario,since the release of tranexamic acid. It also gives an idea about appropriate doses to reduce blood loss, need for blood transfusion, minimize adverse effects and to understand the wide scope of application of TXA to date.

scholarly journals The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: A prospective study

2012 ◽  
Vol 6 (1) ◽  
pp. 70 ◽  
Author(s):  
Kumkum Gupta ◽  
Bhawna Rastogi ◽  
Atul Krishan ◽  
Amit Gupta ◽  
VP Singh ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Prospective Study ◽  
Radical Surgery ◽  
Reduce Blood Loss ◽  
A Prospective Study

The efficacy of Tranexamic Acid Administration in Patients Undergoing Tonsillectomy: An Updated Meta-Analysis

2021 ◽  
pp. 000348942110452
Author(s):  
Cathleen C. Kuo ◽  
Jason C. DeGiovanni ◽  
Michele M. Carr
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Intraoperative Blood Loss ◽  
Reduce Blood Loss ◽  
Dichotomous Data ◽  
Significant Difference ◽  
Acid Administration

Objective: There is controversy regarding the efficacy and safety of tranexamic acid (TXA) in reducing tonsillectomy-related hemorrhage. We conducted a systematic review and meta-analysis to evaluate the prophylactic role of TXA in tonsillectomy. Methods: We searched 6 databases to identify studies that directly compare the effect of TXA versus controls in tonsillectomy patients. Standardized mean difference was applied to summate the findings across the studies. Dichotomous data were expressed as relative risk. Results: Ten studies representing a total of 111 898 patients were included. The pooled results showed a significant reduction of intraoperative blood loss by 39.02 ml (SMD = −1.05, 95% CI: −1.91 to −0.20, P = .016) and the rate of post-tonsillectomy hemorrhage (RR = 0.42, 95% CI: 0.28 to 0.65, P < .0001), with no significant difference in reduction of further intervention risk (RR = 0.78, 95% CI: 0.45 to 1.35, P = .373). Conclusions: Overall, this study indicates that TXA may reduce blood loss and frequency of post-operative hemorrhage associated with tonsillectomy. Further large, high-quality clinical trials are still needed to explore TXA’s effect on post-tonsillectomy hemorrhage and the safety of its use.

The Role of Tranexamic Acid in Controlling Bloodloss During PCNL for Staghorn Calculi

2019 ◽  
Vol 69 (12) ◽  
pp. 3745-3748
Author(s):  
Raluca Costina Barbilian ◽  
Victor Cauni ◽  
Bogdan Mihai ◽  
Ioana Buraga ◽  
Mihai Dragutescu ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Percutaneous Nephrolithotomy ◽  
Kidney Stones ◽  
Postoperative Bleeding ◽  
Invasive Technique ◽  
Transfusion Rate ◽  
Staghorn Calculi ◽  
Type Of Surgery

The aim of this paper is to assess the efficiency and safety of the tranexamic acid in reducing blood loss and the need for transfusion in patients diagnosed with staghorn calculi treated by percutaneous nephrolithotomy. Percutaneous nephrolithotomy (PCNL) is a minimally invasive technique used for large kidney stones. Hemorrhagic complications and urinary sepsis are serious complications associated with this type of surgery. Tranexamic acid is an antifibrinolytic drug that has the property of reducing intra or postoperative bleeding. The experience with tranexamic acid in preventing blood loss during percutaneous nephrolithotomy for is limited. The use tranexamic acid in percutaneous nephrolithotomy for staghorn type stones is safe and is associated with reduced blood loss and a lower transfusion rate.

scholarly journals Intra-Articular Injection of Tranexamic Acid to Reduce Blood Loss after Total Knee Arthroplasty

2014 ◽  
Vol 22 (2) ◽  
pp. 146-149 ◽  
Author(s):  
Bob Jang ◽  
Mark Kao ◽  
Martin T Bohm ◽  
Ian A Harris ◽  
Darren B Chen ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Blood Loss ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Reduce Blood Loss ◽  
Total Knee

Tranexamic Acid: When is It Indicated in Orthopaedic Surgery?

2021 ◽  
Author(s):  
Bjarke Viberg
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Joint Replacement ◽  
Orthopaedic Surgery ◽  
Thromboembolic Events ◽  
Reduce Blood Loss ◽  
Fracture Surgery ◽  
Arthroscopic Procedures

AbstractTranexamic acid (TXA) has been studied extensively during the last 5–8 years. It inhibits clot dissolution during surgery and can therefore reduce blood loss. However, there has been concern that this could result in more frequent complications, specifically in terms of thromboembolic events. The indications for TXA are widespread, and this review covers the literature on orthopaedic indications such as joint replacement, fracture surgery, and arthroscopic procedures. In general, TXA is safe and can be used in a wide variety of orthopaedic procedures, lowering blood loss without increasing the risk of complications.

Can We Safely Reduce Blood Loss During Lumbar Pedicle Subtraction Osteotomy Procedures Using Tranexamic Acid or Aprotinin?

Spine ◽  
2010 ◽  
Vol 35 (2) ◽  
pp. 235-239 ◽  
Author(s):  
Christine R. Baldus ◽  
Keith H. Bridwell ◽  
Lawrence G. Lenke ◽  
Gbolahan O. Okubadejo
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Pedicle Subtraction Osteotomy ◽  
Reduce Blood Loss ◽  
Lumbar Pedicle
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