scholarly journals Estimation of ventricles size of human brain by Magnetic Resonance Imaging in Nepalese Population: A retrospective study

2020 ◽  
Vol 13 (1) ◽  
pp. 45-50
Author(s):  
Sushma Singh ◽  
Bhoj Raj Sharma ◽  
Urusha Prajapati ◽  
Pujan Sharma ◽  
Manoj Bhatta ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Retrospective Study ◽  
Magnetic Resonance ◽  
Fourth Ventricle ◽  
Third Ventricle ◽  
P Value ◽  
Resonance Imaging ◽  
Mean Width ◽  
Significant Difference ◽  
The Mean

Background and Objective: Magnetic resonance imaging (MRI) provides image acquisition of three-dimensional data and measurement in any chosen imaging plane. Objective of this study is to assess the size of ventricles of the brain of normal Nepalese people and establish the range of size of the ventricular system and compute the ventricular dimensions among different age and gender. Materials and methods: This is a cross-sectional retrospective study done at Gandaki Medical College, Pokhara. A total of 106 MRI scan data of healthy individuals were collected over a period of seven months between March to September 2019. Patients ranged between eight and eighty years of age with 58 males and 48 females. Measurements of the mean of bifrontal diameter (BFD), bihemispheric diameter (BHD), third ventricle transverse dimension (TVTD), fourth ventricle antero-posterior dimension (FVAP), fourth ventricle width (FVW), and frontal horn ratio (FHR) were done. Result: The mean of BFD, BHD, TVTD, FVAP, FVW, and FHR were found to be 3.05 ± 0.10 cm, 10.11 ± 0.40 cm, 0.43 ± 0.11 cm, 0.90 ± 0.11 cm, 1.22 ± 0.12 cm, and 0.30 ± 0.01 cm, respectively. The mean width of fourth ventricle in males and females was observed to be 1.23 ± 0.12 cm and 1.19 ± 0.11 cm respectively. There was a significant correlation of TVTD, FVAP, FHR and BFD with age with Pearson correlation coefficient 0.393 (P value <0.01), 0.259 (P value <0.01), 0.34 (P value <0.01), and 0.219 (P value <0.05) respectively. However, BHD and FVW have no correlation with age. Conclusion: Third Ventricle Traverse Dimension, FVP, FVW and FHR show almost similar or slight difference in measurement according to gender. However, BFD shows larger difference in measurement according to gender. Similarly there is no such significant difference according to age in measurement of BFD, BHD, FVAP, FVW and FHR, while TVTD measurement shows slight increased measurement according to age.  

scholarly journals Sexual Dimorphism in Laryngeal Volumetric Measurements Using Magnetic Resonance Imaging

2019 ◽  
Vol 99 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Abdul-Latif Hamdan ◽  
Elie Khalifee ◽  
Georges Ziade ◽  
Sahar Semaan
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Statistical Significance ◽  
Resonance Imaging ◽  
Men And Women ◽  
Mean Width ◽  
Significant Difference ◽  
The Mean ◽  
The Right ◽  
Volumetric Measurements

The objective of this study is to investigate the dimensional and volumetric measurements in the thyroarytenoid (TA) muscle in men and women using magnetic resonance imaging (MRI). The hypothesis is that there is a gender-related difference in these measurements. A retrospective chart review of 76 patients who underwent MRI of the neck at the American University of Beirut Medical Center was conducted. The dimension and volume of the right and left TA muscle were measured on axial and coronal planes short tau inversion recovery images. Male and female groups were compared with respect to demographic data and MRI findings using parametric and nonparametric tests. The mean length of the thyro-arytenoid muscle in males was larger than that in females on the right (males 2.44 [0.29] cm vs females 1.70 [0.22] cm) and on the left (males 2.50 [0.28] cm vs females 1.72 [0.24] cm) reaching statistical significance ( P < .001). The mean width of the thyro-arytenoid muscle in males was larger than that in females on the right (males 0.68 [0.13] cm vs females 0.59 [0.11] cm) and on the left (males 0.68 [0.12] cm vs females 0.57 [0.12] cm) reaching statistical significance ( P < .001). The mean height of the thyro-arytenoid muscle in males was larger than that in females on the right (males 1.05 [0.21] cm vs females 0.95 [0.12] cm) and on the left (males 1.05 [0.21] cm vs females 0.95 [0.12] cm) reaching statistical significance ( P < .01 on the right and P < .05 on the left). The volume of the thyroarytenoid muscle in males was larger than that in females on the right (males 0.86 [0.25] mL vs females 0.48 [0.15] mL) and on the left (males 0.89 [0.27] mL vs females 0.48 [0.17] mL) reaching statistical significance ( P < .001). The results of this investigation clearly indicate a significant difference in these measurements between men and women.

Clinical and Magnetic Resonance Imaging Outcomes of Microfracture Plus Chitosan/Blood Implant vs Microfracture for Osteochondral Lesions of the Talus

2020 ◽  
Vol 41 (11) ◽  
pp. 1368-1375
Author(s):  
Yalkin Camurcu ◽  
Hanifi Ucpunar ◽  
Furkan Yapici ◽  
Resit Karakose ◽  
Seckin Ozcan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Osteochondral Lesions ◽  
Resonance Imaging ◽  
Glycerol Phosphate ◽  
Level Of Evidence ◽  
Repair Tissue ◽  
Significant Difference ◽  
The Mean ◽  
Group 1

Background: The aim of this study was to compare the clinical and magnetic resonance imaging (MRI) outcomes of arthroscopic microfracture (MF) plus chitosan-glycerol phosphate/blood implant and MF alone for the treatment of the osteochondral lesions of the talus (OCLTs). Methods: Patients who underwent either MF plus chitosan (group 1, n = 32) or MF alone (group 2, n = 31) between 2015 and 2019 in 2 separate time periods were retrospectively analyzed. Visual analog scale (VAS) score and American Orthopaedic Foot & Ankle Society (AOFAS) score were used for clinical evaluation. The magnetic resonance observation of cartilage repair tissue (MOCART) system was used for MRI evaluation. The mean follow-up time was 32 ± 13 months (range, 12-61 months). Results: Postoperatively, we detected significant improvements in both groups in terms of VAS and AOFAS scores. However, we observed no statistically significant difference between groups in terms of clinical scores, except the mean VAS function score, which was significantly higher in group 1 ( P = .022). According to MOCART scale, complete repair with the filling of the chondral defect and intactness of the surface of the repair tissue were more common in group 1. However, these parameters did not significantly differ between groups ( P = .257 and .242, respectively). Conclusion: Arthroscopic MF plus chitosan glycerol phosphate/blood implant did not result in better clinical and MRI outcomes compared with MF alone in the treatment of OCLTs. Level of Evidence: Level III, retrospective comparative study.

scholarly journals Clinical and Pathological Attributes of Hepatocellular Carcinoma Showing Lack of Restricted Diffusion on Magnetic Resonance Imaging

2021 ◽  
Author(s):  
Dearada Wancharoenrung ◽  
Kamonwon Cattapan ◽  
Thitinan Chulroek ◽  
Hamed Kordbacheh ◽  
Martina Cecconi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hepatocellular Carcinoma ◽  
Magnetic Resonance ◽  
Survival Rates ◽  
Restricted Diffusion ◽  
P Value ◽  
Resonance Imaging ◽  
Arterial Enhancement ◽  
Significant Difference ◽  
Poorly Differentiated

Objective: To correlate non-restricted diffusion magnetic resonance imaging (MRI) patterns of hepatocellular carcinoma (HCC), with histopathology and clinical outcome.Material and Methods: We retrospectively evaluated pre-treatment MRIs showing non-restricted diffusion HCC lesions (≥1-centimeter), excluding lesions with poor quality/non-available diffusion weighted imaging (DWI). Three radiologists evaluated 37 lesions in 27 patients, for: T1-weighted (T1W)/T2-weighted (T2W) characteristics, arterial enhancement, washout on portal venous/delayed phase, capsular enhancement, intralesional fat component and presence of cirrhosis. Histopathological reports were categorized as: well/moderate/poorly differentiated. Kaplan-Meier survival analysis was calculated for clinical outcome.Results: From a total of 37 lesions, 24 lesions had available pathological grading, which revealed well and moderately differentiated equally (12 lesions each). None of the non-restricted diffusion HCCs were poorly differentiated. Thirty-five of the 37 lesions (94.6%) showed arterial enhancement with washout; 34 lesions (91.9%) were T2W hypo-/isointense, 33 esions (89.2%) were T1W iso-/hyperintense, 19 lesions (51.4%) showed capsular enhancement and 8 lesions (21.6%) had intralesional fat. These findings in the well and moderately differentiated groups were not significantly different (p-value 0.178-1.000). Overall mean-survival was 6.972 years (95% confidence interval (CI); 5.3-8.6). The 1-year, overall survival rate was 83.6% and for 3-years was 67.9%. Mean survival of well and moderately differentiated groups were 6.88 and 7.23 years (95% CI 5.7-8.0 and 4.4-10.1), respectively (p-value=0.319).Conclusion: DWI may help to predict histological grading of HCC and clinical outcome. We found that non-restricted diffusion HCCs were histologically well or moderately differentiated, with no significant difference of imaging findings and survival rates between the two groups. No poorly differentiated lesions were seen in our non-restricted HCC cohort.

scholarly journals Magnetic Resonance Imaging Grading of Pituitary Macroadenoma- SIPAP Classification Revisited.

2021 ◽  
Author(s):  
Shayan Sirat Maheen Anwar ◽  
Kiran Hilal ◽  
Anam Khan ◽  
Asra Ahmad
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Pituitary Adenomas ◽  
Tumour Size ◽  
P Value ◽  
Kappa Statistics ◽  
Pituitary Macroadenoma ◽  
Resonance Imaging ◽  
Tumour Delineation ◽  
Significant Difference

Abstract BACKGROUNDMagnetic resonance imaging (MRI) is regarded as the modality of choice in diagnosis of pituitary adenomas. Since surgery is the first line therapy for all pituitary adenomas with exception of prolactinoma, simple and reproducible MRI classification based on major directions of tumour growth is an essential tool providing the exact road map for right surgical approach and maximum safe resection.SIPAP MRI classification for pituitary adenomas is derived from KNOSP-STEINER classification of parasellar growth, to which has been added grading for superior, inferior, anterior and posterior tumour extension.We, therefore, propose to incorporate SIPAP classification in routine reporting template of pituitary adenomas, for ideal radiological description of tumour delineation, relationship to juxtasellar structures, and tumour size, hence facilitating greater success rate in surgical and subsequent clinical management.METHODSTwo radiologists retrospectively reviewed imaging of 49 patients with biopsy-proven pituitary macroadenoma and graded according to SIPAP classification. Study was conducted at Aga Khan University Hospital from 1st July 2019 to 30th June 2020. Data was analyzed using Stata version 15. Interobserver variability was calculated using Cohen’s Kappa. Comparison between grading before and after treatment was performed by Chi-square test. P values <0.05 were considered statistically significant.RESULTSSixty three percent patients were male and 37% female. Overall, maximum preoperative and postoperative volume was 71.82 cm3 and 49.50 cm3 respectively, with significant difference in pre and post-operative volumes (14.1±17.7 vs. 4.5±10.4, p-value <0.001). Length showed most significant difference pre and post-operatively (2.4±1.1 vs. 1.3±1.1, p-value <0.001). Individual tumour extensions according to SIPAP for pre- and post-operative grading showed significant difference (p-value <0.001), except for anterior extension. For suprasellar extension, 67.3% patients had pre-operative grade 3 and 63.3% had post-operative grade 0. For infrasellar extension, 51.0% had pre-operative grade 2 and 71.4% had post-operative grade 0. Anterior, posterior and parasellar extensions showed increased frequency in grade 0 in post-operative stage compared to pre-operative. Substantial inter-observer agreement was achieved for Superior, Inferior, Anterior and Posterior extent with all Kappa statistics values above 0.7 (p-value <0.001).CONCLUSIONWe propose incorporating simple and objective SIPAP classification in routine MR reporting for ideal pituitary tumour delineation, relationship to juxtasellar structures and tumour size.

Comparison of 2- and 3-Dimensional Shoulder Ultrasound to Magnetic Resonance Imaging in a Community Hospital for the Detection of Supraspinatus Rotator Cuff Tears with Improved Worktime Room Efficiency

2012 ◽  
Vol 63 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Steven Co ◽  
Sonny Bhalla ◽  
Kevin Rowan ◽  
Sven Aippersbach ◽  
Simon Bicknell
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Rotator Cuff ◽  
Wilcoxon Test ◽  
Rotator Cuff Tears ◽  
Resonance Imaging ◽  
3 Dimensional ◽  
Significant Difference ◽  
The Mean ◽  
2D And 3D

Purpose The purpose of this study was to evaluate whether 3-dimensional (3D) volumetric acquisition of shoulder ultrasound (US) data for supraspinatus rotator cuff tears is as sensitive when compared with conventional 2-dimensional (2D) US and routine magnetic resonance imaging (MRI), and whether there is improved workroom time efficiency when using the 3D technique compared with the 2D technique. Methods In this prospective study, 39 shoulders underwent US and MRI examination of their rotator cuff to confirm the accuracy of both the 2D and 3D techniques. The difference in sensitivities was compared by using confidence interval analysis. The mean times required to obtain the 2D and 3D US data and to review the scans were compared by using a 1-tailed Wilcoxon test. Results Sensitivity and specificity of 2D US in detecting supraspinatus full- and partial-thickness tears was 100% and 96%, and 80% and 100%, respectively, and similar values were obtained with 3D US at 100% and 100%, and 90% and 96.6%, respectively. Analysis of the confidence limits of the sensitivities showed no significant difference. The mean time (± SD) of the overall 2D examination of the shoulder, including interpretation was 10.02 ± 3.28 minutes, whereas, for the 3D examination, it was 7.08 ± 0.35 minutes. Comparison between the 2 cohorts when using a 1-tailed Wilcoxon test showed a statistically significant difference ( P < .05). Conclusion 3D US of the shoulder is as accurate as 2D US when compared with MRI for the diagnosis of full- and partial-thickness supraspinatus rotator cuff tears, and 3D US examination significantly reduced the time between the initial scan and the radiologist interpretation, ultimately improving workplace efficiency.

Effect of Modified Lemaire Anterolateral Extra-articular Tenodesis on the Magnetic Resonance Imaging Maturity Signal of Anterior Cruciate Ligament Hamstring Graft

2021 ◽  
pp. 036354652110188
Author(s):  
Gonzalo Rojas ◽  
Simone Perelli ◽  
Maximiliano Ibanez ◽  
Mario Formagnana ◽  
Inmaculada Ormazabal ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Anterior Cruciate Ligament ◽  
Magnetic Resonance ◽  
Cruciate Ligament ◽  
Hamstring Tendon ◽  
Resonance Imaging ◽  
Acl Graft ◽  
Significant Difference ◽  
The Mean ◽  
Anterior Cruciate

Background: Lateral extra-articular tenodesis (LET) is one of the most widely used procedures to restore anterolateral stability. Clinical outcomes after the addition of LET to anterior cruciate ligament (ACL) reconstruction (ACLR) have been widely investigated; however, the potential influence of LET on the ACL ligamentization process has not been examined. Purpose/Hypothesis: The purpose was to use 10-month postoperative magnetic resonance imaging (MRI) scans to determine whether the maturity of grafts after hamstring autograft ACLR was affected by concomitant LET. The hypothesis was that when modified Lemaire lateral extra-articular tenodesis (MLLET) was performed, the MRI parameters of ACL graft maturity would be modified. Study Design: Cohort study; Level of evidence, 3. Methods: The study included patients treated between December 2017 and December 2018 who had undergone anatomic 3-strand hamstring tendon autograft ACLR, with or without concomitant MLLET, and had undergone MRI 10 months postoperatively. Thus, the study included 30 patients who had isolated ACLR and 22 patients who had ACLR plus MLLET. The 2 groups were comparable based on all criteria analyzed. To evaluate graft maturity, the signal-to-noise quotient (SNQ) was measured in 3 regions of interest of the proximal, midsubstance, and distal ACL graft. Lower SNQ ratios indicate less water content and, theoretically, better maturity and healing of the graft. Results: The mean ± SD for SNQ was 4.62 ± 4.29 (range, 3.12-6.19) in the isolated ACLR group and 7.59 ± 4.68 (range, 4.38-8.04) in the ACLR plus MLLET group ( P = .012). Upon comparing the mean values of the 3 portions between the 2 groups, we found a significant difference between the 2 groups for the proximal and middle portions ( P = .007 and P = .049, respectively) but no difference in the distal portion ( P = .369). Conclusion: At the 10-month follow-up, hamstring tendon autografts for anatomic ACLR with MLLET did not show the same MRI signal intensity compared with isolated hamstring anatomic ACLR.

scholarly journals Magnetic Resonance Imaging Findings in Spondylodiscitis

2018 ◽  
Vol 15 (3) ◽  
pp. 217-221 ◽  
Author(s):  
Om Biju Panta ◽  
Yagya Raj Pathak ◽  
Dan Bahadur Karki
Keyword(s):  
Magnetic Resonance Imaging ◽  
Lumbar Spine ◽  
Magnetic Resonance ◽  
Thoracic Spine ◽  
Multimodality Imaging ◽  
Imaging Modality ◽  
High Sensitivity ◽  
Resonance Imaging ◽  
Significant Difference ◽  
The Mean

Background: Magnetic Resonance Imaging is the imaging modality of choice for imaging spinal infection due to its high sensitivity and specificity. This study aims to study the magnetic resonance imaging changes in patients with spondylodiscitis.Methods: The study was a retrospective study carried in a multimodality imaging centre in Kathmandu. Magnetic resonance imaging records and clinical record of 3 years duration were reviewed and patients with clinical and radiological diagnosis of spondylodiscitis were included in the study. Three radiologists interpreted Magnetic Resonance Imaging with mutual consensus in disputed issues. Data analysis was done with Statistical Package for Social Sciences21.0.Results: A total of 52 patients were included in the study. The mean age of the patients was 43.9 ± 17.6 years. Spondylodiscitis involved lumbar spine in 26(50%) case, cervical and thoracic spine in 13(25%) cases each. Multiple IV discs were involved in 24(46.2%) cases, which was most common in cervical spine and least common in thoracic spine. Only one vertebral end plate was involved in 16(30.8%) cases. Epidural collection was seen in 23(44.2%) cases and paravertebral collection was noted in 63(33.5%) cases. Statistical significant difference in region of spine involved (p=0.02) and epidural collection (p=0.04) was noted between genders.Conclusions: Lumbar spine was the most common level involved with spondylodiscitis, perivertebral enhancing soft tissue was present in all cases, and involvement of disc and the endplates were the most common pattern.

scholarly journals Ultrasound and magnetic resonance imaging evaluation of the femoral and sciatic nerves. A study of healthy volunteers

2020 ◽  
Author(s):  
Georgeta Mihaela Rusu ◽  
Andra Diana Curcean ◽  
Sorin Marian Dudea
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Healthy Volunteers ◽  
Reference Values ◽  
Femoral Nerve ◽  
Anatomical Location ◽  
Resonance Imaging ◽  
Significant Difference ◽  
The Mean ◽  
Sciatic Nerves

Background and aims. The study describes the femoral (FN) and sciatic nerves (SN), explored using ultrasound (US) and magnetic resonance imaging (MRI). The aims of the study are: to establish US / MRI correlations and define reference values: for the anteroposterior (AP) and mediolateral (ML) diameters and cross-sectional area (CSA) of the two nerves respectively, in well-defined anatomical measuring sites; to analyze the intraobserver variation; to define the value with least variability; to determine differences between the right-left and male-female reference values. Methods. A prospective study was carried out on 24 healthy volunteers (11 men and 13 women). MRI scans were performed using a 1.5T system. To visualize both nerves (FN and SN), a single 3D T2 weighted acquisition was performed, in the coronal plane, with a wide FOV. For ultrasonographic examinations, a Hitachi EUB-8500 ultrasound machine, equipped with a 13 MHz linear transducer was used. The measurements were performed at well-defined anatomical locations. The mean reference values of the AP, ML diameters and CSA were calculated for femoral and sciatic nerves, both on MRI and US. The correlations between the values determined by the two techniques were analyzed. The intra-observer variation was calculated by measuring the nerves at the same anatomical location at two separate time points. Results. Wilcoxon matched-pairs signed rank test indicated a non-significant difference (p> 0.05) for the femoral and sciatic nerves, on both sides, except the femoral nerve ML diameter on MRI (p= 0.014). The mean MRI and US reference values for the femoral nerve were calculated between the psoas and iliac muscles: FNAPMRI 4.533 ± 0.486, FNAPUS 4.800 ± 1.237, FNMLMRI 6.172 ± 1.203, FNMLUS 7.685 ± 3.338, FNCSAMRI 24.811 ± 3.394, FNCSAUS 26.285 ± 17.608. The mean MRI and US measurements for the sciatic nerve were determined under the buttock, at the level of the ischial tuberosity: SNAPMRI 5.500 ± 1.201, SNAPUS 5.975 ± 1.312, SNMLMRI 10.375 ± 2.272, SNMLUS 13.500 ± 1.661, SNCSAMRI 50.625 ± 15.373, SNCSAUS 53.631 ± 15.847. The MRI and US differences between right and left sides, both for the femoral and sciatic nerves were insignificant. In selected cases, Wilcoxon paired test indicated differences between subjects, according to their gender, both on MRI and US. Conclusion. Reference values for the femoral and sciatic nerves at specific anatomical sites were identified. Side to side variation and gender related differences add to current knowledge on nerve size in young Caucasian population.

scholarly journals Measurement of Corpus Callosum Size Using MRI In Nepalese Population

2021 ◽  
Vol 9 (3.3) ◽  
pp. 8079-8085
Author(s):  
Suman Gnawali ◽  
◽  
Ajay Kumar Yadav ◽  
Mukunda Psd Humagain ◽  
Prakash Kayastha ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Corpus Callosum ◽  
Spin Echo ◽  
Pearson Correlation ◽  
P Value ◽  
Slice Thickness ◽  
Resonance Imaging ◽  
The Mean ◽  
Magnetic Resonance Imaging Mri

Corpus callosum (CC) is the main fiber tract connecting the cortical and sub-cortical regions of the right, left hemispheres, and plays an essential role in the integration of information between the two hemispheres. By using magnetic resonance imaging (MRI), the dimensions of corpus callosum can be studied. In this cross-sectional quantitative study 80 cases of normal MRI head were selected for study over two months. T1 weighted sagittal spin-echo images with slice thickness of 6 mm, planned from an axial and coronal image were used for measuring length and thickness of corpus callosum. Obtained data were analyzed using SPSS ver.20 software and shown in frequency, percentages and bar diagram. The mean Corpus callosum (CC) length was 68.06 mm in the study population (n=80). The mean thickness of Genu, Body and Splenium were 9.15,5.2 and 9.08 mm respectively and average thickness was 7.81 mm. Statistically significant differences in size of CC for various age groups in both sexes were observed. The mean length of CC was 68.06 mm and mean thickness of CC was 7.81 mm. There were variation in the size of CC with age and sex. The Pearson correlation Coefficient is 0.48829 between Age and Length of CC, its P-value is 0.0019 KEY WORD: Magnetic Resonance Imaging (MRI), Corpus callosum (CC), Genu, Body, Splenium Sagittal Spin-Echo.

A Study to Evaluate the Role of Diffusion Weighted Imaging in Detection and Staging of Prostate Cancer and Correlation with Histopathology in and around East Godavari

2021 ◽  
Vol 8 (41) ◽  
pp. 3513-3518
Author(s):  
Sowmya D. ◽  
Anusha S. ◽  
Hari Babu Pidaparti P. ◽  
Jaya Chandra T. ◽  
Mytri Priyadarshini K.
Keyword(s):  
Magnetic Resonance Imaging ◽  
Prostate Cancer ◽  
Magnetic Resonance ◽  
Diffusion Weighted Imaging ◽  
Specific Antigen ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
The Mean

BACKGROUND Prostate is an associated gland of the male reproductive system. Worldwide, among the men, prostate cancer (PC) is the second most common cancer. PC is the seventh commonest cancers among the Indian male. Studies reported that diffusion weighted imaging (DWI) and dynamic contrast enhanced imaging (DCE-MRI), can offer additional value in localizing cancer. A study was conducted to evaluate and correlate the role of DWI in detection and staging of PC and correlation with histopathology. METHODS A cross-sectional observational study was conducted in the Department of Radiodiagnosis, GSL Medical College, over a period of 18 months. Males with symptoms of nocturia, urinary urgency, frequency, hesitancy and bone pain were included in the study. Trans rectal ultrasound scan (TRUS) biopsy was collected, Gleason‘s score (GS) was considered for the histopathologic analysis. The evaluation of DWI as a tool for detection of PC was based on comparing the sensitivity and specificity of the results after taking histopathology as the gold standard test chi-square test was used to find the statistical significance and P < 0.05 was considered statistically significant. RESULTS Total, 36 (82 %) were diagnosed to be malignant, maximum number (18; 50 %) were between 61 – 70 years age group. Peripheral zone is the most common (61.2 %; 22) area for the PC followed by transitional (33.3 %) and central zone (5.5 %). In this study, 16.6 % members had GS ≤6; Apparent diffusion coefficient (ADC) was ranged between 0.81 to 0.87 and mean + SD were 0.85 + 0.02. Out of the 22.2 % members whose GS was 7, the mean + SD ADC were 0.74 ± 0.02. For 22 (61 %) members, GS was >8; the mean + SD ADC was 0.63 ± 0.08; statistically there was significant difference between the parameters. Magnetic resonance imaging (MRI) revealed that 61.3 % (27) cases as highly suspicious, 25 % (11) as probably malignant and 13.6 % (6) as indeterminate; the sensitivity for MRI was 94.5 % and specificity was 85.7 %. CONCLUSIONS Patients with increased prostate specific antigen (PSA), multi-parametric magnetic resonance imaging (MPMRI) is valuable, non-invasive and a better option to detect PC. Also helps in localizing the exact location. KEYWORDS Cancer, Tumour, Biopsy, Study

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