Clinical and laboratory profile of dengue fever in children from a tertiary care centre of Gandaki Province, Nepal

Introduction: Dengue, the arthropod borne viral disease is serious public health problem in Nepal. The clinical diagnosis of dengue has become challenging in children as it is presented with nonspecific symptoms. The objective of present study was to assess different clinical presentations and outcomes of dengue fever in tertiary care centre. Methods: A record based observational cross-sectional study was carried out on all dengue positive patients of aged 11 months to 15 years presented in Gandaki Medical College from July to November 2019. Total 74 patients with history of fever with dengue seropositive were included in the study. All the clinical and haematological findings were recorded in semi-structured questionnaire form. Results: Of 74 patients 40 (54.1%) males and 34 (45.9%) were females. Fiftyone (68.9%) were cases of dengue without warning sign, 18 (24.3%) were dengue with warning signs and 5(6.8%) cases had severe dengue symptoms. Most of the patients (78.38%) were from Kaski district. Fever (100%) was the most common clinical presentation followed by headache (36.5%), vomiting (25.7%), and retro orbital pain (20.3%). Common laboratory findings included thrombocytopenia (59.4%) and leukopenia (35.1%). Among 74 cases, 68 were in stable condition and treated in OPD or in ward, and 6 were admitted in ICU of which one developed warning signs and other 5 had severe dengue. All the enrolled children recovered well and there was no mortality during this period. Conclusions: Fever, headache, vomiting, thrombocytopenia and leukopenia were most common presentation of dengue fever among children. Appropriate clinico-laboratory diagnosis and management is relatively simple, inexpensive and very effective in saving lives as long as correct and timely interventions are instituted.

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Clinical profile and outcome of dengue fever in a paediatric tertiary care centre

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20171689 ◽

2017 ◽

Vol 4 (3) ◽

pp. 875

Author(s):

Md Khaja Moinuddin ◽

Sahana Devadas Sahana Devadas

Keyword(s):

Dengue Fever ◽

Tertiary Care ◽

Febrile Illness ◽

Warning Signs ◽

Severe Dengue ◽

Tertiary Care Centre ◽

Laboratory Findings ◽

Cross Sectional ◽

Stable Conditions ◽

Elevated Liver Enzymes

Background: A study of different presentation and outcome of dengue fever in tertiary care centre.Methods: the observational cross sectional study was carried out from June to October 2016 in Bowring and Lady Curzon hospital attached to Bangalore Medical College and Research Institute. Included patients from 1 to 18 years of age who presented with febrile illness. WHO classification and definitions were used to classify disease as dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS). Clinically, haematological and biochemical findings were recorded till discharge.Results: during study period,142 patients presented with typical features of dengue fever, male being 86 (60%) and female being 56 (40%). Among 142 cases 64 cases were probable dengue, 50 cases were dengue with warning signs and 28 cases were had severe dengue. Fever (100%) was the most common clinical presentation followed by vomiting (70%), body ache (43%), abdominal pain (23%), headache (12%) and rashes (5%). Laboratory findings included thrombocytopenia, leucopenia and elevated liver enzymes. 126 (88%) cases were discharged in clinical stable conditions, (8%) were died during course of treatment and 8 cases left against medical advice.Conclusions: fever with vomiting and thrombocytopenia were most common presentation of dengue fever, appropriate clinical diagnosis and management is relatively simple, inexpensive and very effective in saving lives as long as long correct and timely interventions instituted.

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A study to determine the severity based outcome of pediatric patients with dengue spectrum disorders in a tertiary care hospital

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20195745 ◽

2019 ◽

Vol 7 (1) ◽

pp. 154

Author(s):

Vijaysuryakiran K. M. ◽

Mounesh Pattar ◽

Sanjay Paida

Keyword(s):

Dengue Fever ◽

Dengue Infection ◽

Tertiary Care ◽

Warning Signs ◽

Severe Dengue ◽

Warning Sign ◽

High Morbidity ◽

Care Hospital ◽

Increased Risk ◽

Spectrum Disorders

Background: Dengue Fever (DF) has become a major global public health problem. The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. Dengue infection ranges from mild illness to a severe form of haemorrhagic fever and shock syndrome which may prove fatal. Objective of the study was to determine severity-based outcome in children with dengue spectrum disorder in a tertiary care centre in Mumbai.Methods: It was a prospective, non-interventional, observational, surveillance study conducted over 14 months (from September 2016 till October 2017). Children aged <18 years admitted to Nanavati Super Specialty Hospital, Mumbai diagnosed with dengue spectrum disorders according to WHO 2009 classification with clinical features and laboratory investigation confirming dengue were enrolled as study participants.Results: Out of 127 patients, 57(44.9%) were females and 70(55.1%) were males. 81(63.8%) were ward patients, 46(36.2%) required PICU admission. 17(13.4%) patients had dengue with warning signs, 100(78.7%) had dengue without warning signs and 10(7.9%) had severe dengue according to WHO 2009 case classification of dengue. 122(96.1%) were discharged home, 4(3.1%) died of dengue and dengue related complications all four deaths occurred in children with severe dengue.Conclusions: This study showed that commonest inpatient admission category among children with dengue according to WHO 2009 classification was dengue without warning signs Overall mortality in patients with dengue fever without warning sign as well those with warning sign remains very low. Children presenting with severe dengue associated with either organ failure or refractory shock are at increased risk of mortality.

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Study of dengue fever in Bihar population at a tertiary care centre (JLNMCH, Bhagalpur)

Medpusle International Journal of Medicine ◽

10.26611/10211313 ◽

2020 ◽

Vol 13 (1) ◽

pp. 09-12

Author(s):

Amrendra Kumar Singh ◽

◽

Gagan Gunjan ◽

Rajkamal Choudhary ◽

Ajay Kumar ◽

...

Keyword(s):

Dengue Fever ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre

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Severity and costs associated with hospitalization for dengue in public and private hospitals of Surat city, Gujarat, India, 2017–2018

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/trz057 ◽

2019 ◽

Vol 113 (11) ◽

pp. 661-669 ◽

Cited By ~ 1

Author(s):

Viral R Bajwala ◽

Denny John ◽

T Daniel Rajasekar ◽

Manoj V Murhekar

Keyword(s):

Urban Areas ◽

Tertiary Care ◽

Public Health Problem ◽

Warning Signs ◽

World Health ◽

Severe Dengue ◽

Major Public Health Problem ◽

Private Hospitals ◽

Government Hospitals ◽

The Cost

Abstract Background Dengue is major public health problem in India, especially in urban areas. We conducted a study to estimate the severity and costs of treatment among hospitalized dengue patients in Surat city, Gujarat, India. Methods We reviewed the medical records of dengue patients hospitalized in five tertiary care facilities (private [n=2], semi-government [n=2] and government [n=1]) between April 2017 and March 2018. We used the World Health Organization 2009 classification to classify the severity of dengue. A resource utilization approach was used to estimate the cost of illness in US dollars (US$) (inflation adjusted to 2018) from a quasi-societal perspective (excluding non-medical cost) for dengue hospitalization. Results Of the 732 hospitalized dengue patients, 44.7% had no warning symptoms, 39.5% had warning signs and 15.8% had severe dengue. The mean cost of hospitalization was US$86.9±170.7. The cost of hospitalization was 28.8 times higher in private hospitals compared with government hospitals. Consultant charges in private hospitals, laboratory investigations in semi-government hospitals and registration with admission charges in government hospitals accounted for 27.3%, 39.4% and 53% of the direct cost in these facilities, respectively. Conclusions A better triage system for hospitalization, subsidizing costs in the public sector and cost capping in the private sector can help to reduce the cost of hospitalization due to dengue so as to ensure affordability for larger portion of the society for universal health coverage.

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Clinicoepidemiological and laboratory findings of COVID positive patients presenting to a tertiary care centre in South India: A retrospective analysis

Clinical Epidemiology and Global Health ◽

10.1016/j.cegh.2021.100931 ◽

2021 ◽

pp. 100931

Author(s):

Diya Biju ◽

Soumya Johnson ◽

Chithra Valsan ◽

Prasad A.B ◽

Praveenlal Kuttichira

Keyword(s):

Retrospective Analysis ◽

South India ◽

Tertiary Care ◽

Care Centre ◽

Tertiary Care Centre ◽

Laboratory Findings

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Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20184293 ◽

2018 ◽

Vol 5 (6) ◽

pp. 2265 ◽

Cited By ~ 1

Author(s):

Senthil Kumar K. ◽

Rajendran N. K. ◽

Ajith Brabhukumar C.

Keyword(s):

Dengue Fever ◽

Dengue Infection ◽

Tertiary Care ◽

Hemorrhagic Fever ◽

Warning Signs ◽

Clinical Profile ◽

Severe Dengue ◽

High Morbidity ◽

Care Hospital ◽

High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

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Haemorrhagic manifestations and utility of haematological parameters in dengue fever: A tertiary care centre experience at Karachi

Scandinavian Journal of Infectious Diseases ◽

10.1080/00365540701411492 ◽

2007 ◽

Vol 39 (11-12) ◽

pp. 1025-1028 ◽

Cited By ~ 12

Author(s):

Natasha Ali ◽

Mohammad Usman ◽

Naveen Syed ◽

Mohammad Khurshid

Keyword(s):

Dengue Fever ◽

Tertiary Care ◽

Haematological Parameters ◽

Care Centre ◽

Tertiary Care Centre

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EPIDEMIOLOGICAL STUDY OF TRAUMA IN A TERTIARY CARE CENTRE IN NORTHWEST INDIA

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i12.2340 ◽

2021 ◽

Vol 5 (12) ◽

Author(s):

Mohit Badgurjar ◽

Vaibhav Lakhanpal ◽

Pankaj Saxena ◽

Suman Parihar ◽

Poojan Thakor ◽

...

Keyword(s):

Road Traffic ◽

Tertiary Care ◽

Total Mortality ◽

Public Health Problem ◽

Common Mechanism ◽

Mechanism Of Injury ◽

Care Centre ◽

Tertiary Care Centre ◽

Keywords Trauma ◽

Number Of Patients

Objective: Traumatic injuries are a matter of concern worldwide. However, the rapidly changing socio economical dynamics in a developing country like India deeply influence the epidemiology behind trauma. The aim of this study was to document and analyze the epidemiological parameters and characteristics behind trauma victims admitted to our tertiary care centre. Methods: The observational study was carried out over a period of one year (January 2019 to December 2019) enrolling a total of 300 trauma patients. The age, sex, locality, delay in hospitalization, mechanism of injury, sites of injury and outcomes were documented. Results: Injuries occurred predominantly in the 20-40 age group with males being the chief victims. There was a considerable amount of delay in hospitalization ranging from one hour to more than 24 hours while only 7 patients arrived to the emergency within one hour of trauma. Vehicular trauma (54%) was the most common mechanism of injury. Injuries to the extremities (38.6%) and head (28.6%) were the most common sites. A considerable number of patients (45.3%) required care in the intensive care unit. A total of 172 patients required surgical interventions of various kinds and there was a total mortality rate of 6%. Amongst the polytrauma cases, 54 patients (81.8%) required ICU admission, 42 patients (63.6%) required surgical intervention and 6 patients (9.1%) died after admission. Conclusion: The results of this study highlight some of the problems with our existing infrastructure bringing to light the need for stricter enforcement of traffic safety laws and improvement of infrastructure particularly the roadways in rural areas as well as the referral systems. Vehicular trauma should be seen as a public health problem and appropriate interventions should be implemented. Keywords: Trauma, Road Traffic Accidents, Epidemiology, Head injuries

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Study of clinico-epidemiological profile of leprosy patients at tertiary care centre of South Gujarat region

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20201580 ◽

2020 ◽

Vol 6 (3) ◽

pp. 355

Author(s):

Kautuk K. Patel ◽

Anjum M. Momin ◽

Ankita A. Mistry ◽

Jignesh B. Vaishnani

Keyword(s):

Tertiary Care ◽

National Level ◽

Public Health Problem ◽

Warning Signs ◽

Tertiary Care Centre ◽

Female Ratio ◽

Male Female Ratio ◽

Leprosy Patients ◽

Epidemiological Profile ◽

Epidemiological Characteristics

Background: Leprosy is a chronic feared illness causes by Mycobacterium leprae. It was eliminated as a public health problem in India in 2005. But still, India contributes more than 60% of all new cases of leprosy.Methods: A retrospective analysis of 307 patients attending the leprosy clinic of the dermatology out patient department, SMIMER, was done for a period of five years from January 2014 to December 2018. The data was analysed for clinical and epidemiological characteristics of the patients.Results: A total of 307 patients visited the leprosy clinic during the study period. More than half patients (60.3%) were between 21-40 years age group. There were 213 males and 94 females with male female ratio of 2.3:1. 72.3% (222) patients were suffering from multibacillary leprosy and 27.7% (85) had paucibacillary disease. Borderline tuberculoid leprosy was the most common type found in 83 patients (27.1%). 16 cases (5.2%) of childhood leprosy (less than 14 years of age) were noted. A total of 214 patients (69.7%) were migrants.Conclusions: Despite of decline at global and national level, leprosy cases show gradual increase. The high proportion of total cases, MB cases, and grade 2 disability cases are warning signs. Continued efforts are required to manage and prevent the disease.

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