scholarly journals Smear technique for intraoperative diagnosis of central nervous system neoplasms

2014 ◽  
Vol 4 (7) ◽  
pp. 544-547
Author(s):  
S Shrestha ◽  
BK Thapa ◽  
B Bhattarai
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histopathological Examination ◽  
Frozen Section ◽  
Cost Effective ◽  
Metastatic Tumor ◽  
Rapid Diagnosis ◽  
Central Nervous System Neoplasms ◽  
A Prospective Study ◽  
Nervous System Neoplasms

Background: Smear cytology has become increasily popular as an alternative to frozen section for the rapid diagnosis of most of central nervous system lesions. The aim of this study was to assess the utility of smear technique for the rapid diagnosis in the neurosurgical biopsies and to compare the smear cytological features with the final histopathological examination. Materials and Methods: This was a prospective study conducted in the Department of Pathology of BP Koirala Memorial cancer Hospital for a period of one year. Sixty cases of clinically suspected CNS tumors were sent for intraoperative smear cytological examination and histological examination. Both techniques were then compared for their ability to diagnose as well as grade the tumors. Results: Gliomas (51.6%) were the most frequently occurring tumors in the total cases. Diagnostic accuracy of squash/smear technique achieved was 88 %( 53/60) when compared with histopathological diagnoses. In two cases, smears comprised of blood clots and no opinion was possible in cytology. Complete discrepancy was seen in five cases that included two cases of atypical meningioma, a one case each of germinoma, glioblastoma and metastatic tumor. Conclusion: Smear technique is a fairly accurate, rapid, easily reproducible and cost effective tool to diagnose brain tumours. Smear cytology is of great value in Intraoperative consultation of central nervous system lesions. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10296 Journal of Pathology of Nepal (2014) Vol. 4, 544-547 

scholarly journals Intraoperative consultation and smear cytology in the diagnosis of brain tumours

1970 ◽  
Vol 6 (4) ◽  
pp. 453-457 ◽  
Author(s):  
JR Kini ◽  
V Jeyraj ◽  
CS Jayaprakash ◽  
S Indira ◽  
CNR Naik
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumours ◽  
Isotonic Saline ◽  
Paraffin Section ◽  
Cost Effective ◽  
Histopathological Diagnosis ◽  
Central Nervous System Neoplasms ◽  
Smear Preparation ◽  
Nervous System Neoplasms

Background: Intraoperative smear cytology provides a rapid and reliable intraoperative diagnosis and guidance to the neurosurgeon during surgical resection and lesion targeting. It also helps the surgeon to monitor and modify the approach at surgery. Objectives: 1) To assess the utility of intraoperative smear cytology and correlate with the final histopathological diagnosis. 2) To describe the cytomorphological features of common brain tumours in smear preparation. Materials and methods: The material for this study was obtained from 100 consecutive biopsies of central nervous system neoplasms sent for intraoperative consultation. Smears were prepared from the biopsy samples sent in isotonic saline for immediate processing. The smears were stained by the rapid Haematoxylin and Eosin method. The cytomorphological features were noted and correlated with paraffin section findings. Results: Of the total 100 cases, 86 showed accuracy when compared with histopathological diagnosis. This was comparable with other studies. Of the remaining, two cases were frank errors, 12 cases showed partial correlation, with five cases showed incomplete typing of the cell type and seven, discrepancy in grading of tumours. The error percentage was 14%. Correlation with clinical details and radiological findings were helpful in improving the accuracy rate. Conclusions: Smear technique is a fairly accurate, relatively safe, rapid, simple, easily reproducible and cost effective tool to diagnose brain tumours. Smear cytology is of great value in intraoperative consultation of central nervous system pathology. Key words: Intraoperative consultation, smear cytology, central nervous system neoplasms   doi: 10.3126/kumj.v6i4.1734   Kathmandu University Medical Journal (2008), Vol. 6, No. 4, Issue 24, 453-457

scholarly journals An Update on Neurofibromatosis Type 1-Associated Gliomas

Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 114 ◽  
Author(s):  
Lobbous ◽  
Bernstock ◽  
Coffee ◽  
Friedman ◽  
Metrock ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurofibromatosis Type 1 ◽  
Autosomal Dominant ◽  
Neurofibromatosis Type ◽  
Central Nervous System Neoplasms ◽  
Therapeutic Landscape ◽  
Nervous System Neoplasms ◽  
Collaborative Efforts

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that affects children and adults. Individuals with NF1 are at high risk for central nervous system neoplasms including gliomas. The purpose of this review is to discuss the spectrum of intracranial gliomas arising in individuals with NF1 with a focus on recent preclinical and clinical data. In this review, possible mechanisms of gliomagenesis are discussed, including the contribution of different signaling pathways and tumor microenvironment. Furthermore, we discuss the recent notable advances in the developing therapeutic landscape for NF1-associated gliomas including clinical trials and collaborative efforts.

Extramedullary Spinal Cord Tumors

2018 ◽  
Author(s):  
J. Bradley Elder ◽  
Ahmed Mohyeldin
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Specific Area ◽  
Spinal Cord Tumors ◽  
Central Nervous System Neoplasms ◽  
Case Presentation ◽  
Presenting Symptoms ◽  
Spine Tumors ◽  
Nervous System Neoplasms

Tumors of the spine that occur within the dura but outside of the spinal cord are characterized as intradural but extramedullary spine tumors. The vast majority of these tumors are benign. This chapter uses a case presentation to present diagnostic and management pearls for this anatomic category of central nervous system neoplasms. These tumors are typically diagnosed due to presenting symptoms including pain or neurologic symptoms that localize the tumor to a specific area of the spine. Management is typically surgical. Some types of tumors are associated with syndromes such as neurofibromatosis. This chapter also discusses potential pitfalls and complications and their management.

Coexpression of Genes Involved in Apoptosis in Central Nervous System Neoplasms

1999 ◽  
Vol 21 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Carol S. Bruggers ◽  
Dan Fults ◽  
Sherrie L. Perkins ◽  
Cheryl M. Coffin ◽  
William L. Carroll
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Neoplasms ◽  
Nervous System Neoplasms
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