Cellular level studies and coil system design for transcranial magnetic stimulation

One of the leading approaches to non-invasively treat a variety of brain disorders is transcranial magnetic stimulation (TMS). However, despite its clinical prevalence, very little is known about the action of TMS at the cellular level let alone what effect it might have at the subcellular level (e.g. dendrites). Here, we examine the effect of single-pulse TMS on dendritic activity in layer 5 pyramidal neurons of the somatosensory cortex using an optical fiber imaging approach. We find that TMS causes GABAB-mediated inhibition of sensory-evoked dendritic Ca2+ activity. We conclude that TMS directly activates fibers within the upper cortical layers that leads to the activation of dendrite-targeting inhibitory neurons which in turn suppress dendritic Ca2+ activity. This result implies a specificity of TMS at the dendritic level that could in principle be exploited for investigating these structures non-invasively.

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Design of a Dynamic Transcranial Magnetic Stimulation Coil System

Journal of Medical Systems ◽

10.1007/s10916-014-0064-7 ◽

2014 ◽

Vol 38 (8) ◽

Cited By ~ 2

Author(s):

Sheng Ge ◽

Ruoli Jiang ◽

Ruimin Wang ◽

Ji Chen

Keyword(s):

Transcranial Magnetic Stimulation ◽

Magnetic Stimulation ◽

Coil System

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Modern concepts of the pathogenesis of obesity and new approaches to its correction

Obesity and metabolism ◽

10.14341/omet9491 ◽

2018 ◽

Vol 15 (2) ◽

pp. 11-16

Author(s):

Oksana V. Logvinova ◽

Alexandra G. Poydasheva ◽

Ilya S. Bakulin ◽

Olga V. Lagoda ◽

Elena I. Kremneva ◽

...

Keyword(s):

Eating Disorders ◽

Electrical Stimulation ◽

Transcranial Magnetic Stimulation ◽

Brain Stimulation ◽

Magnetic Stimulation ◽

Cellular Level ◽

Transcranial Electrical Stimulation ◽

Food Behavior ◽

Physiological Mechanisms ◽

Non Invasive

The present review considers modern concepts of the physiological mechanisms of the formation of food behavior in a norm at several levels, beginning with the cellular level and ending with the level of functional systems. Neuroimaging methods used for both the study of the pathophysiological foundations of eating disorders and for determining the target for neurostimulation techniques are described. Methods of non-invasive brain stimulation such as transcranial magnetic stimulation and transcranial electrical stimulation, the mechanisms of their influence and aspects of safety of application are reviewed, the latest data on the results of studies on the use of the above methods in the therapy of obesity are summarized.

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Modern concepts of the pathogenesis of obesity and new approaches to its correction

Obesity and metabolism ◽

10.14341/omet2018211-16 ◽

2018 ◽

Vol 15 (2) ◽

pp. 11-16

Author(s):

Oksana Viktorovna Logvinova ◽

Alexandra Georgievna Poydasheva ◽

Ilya Sergeevich Bakulin ◽

Olga Viktorovna Lagoda ◽

Elena Igorevna Kremneva ◽

...

Keyword(s):

Eating Disorders ◽

Electrical Stimulation ◽

Transcranial Magnetic Stimulation ◽

Brain Stimulation ◽

Magnetic Stimulation ◽

Cellular Level ◽

Transcranial Electrical Stimulation ◽

Food Behavior ◽

Physiological Mechanisms ◽

Non Invasive

The present review considers modern concepts of the physiological mechanisms of the formation of food behavior in a norm at several levels, beginning with the cellular level and ending with the level of functional systems. Neuroimaging methods used for both the study of the pathophysiological foundations of eating disorders and for determining the target for neurostimulation techniques are described. Methods of non-invasive brain stimulation such as transcranial magnetic stimulation and transcranial electrical stimulation, the mechanisms of their influence and aspects of safety of application are reviewed, the latest data on the results of studies on the use of the above methods in the therapy of obesity are summarized.

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