scholarly journals Metastatic Adenocarcinoma of the Lung Mimicking Spinal Tuberculosis

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Zamzuri Z ◽  
Adham SY ◽  
Shukrimi A ◽  
Azril MA ◽  
Amran R
Keyword(s):  
Spinal Tuberculosis ◽  
Clinical Findings ◽  
Unknown Primary ◽  
Metastatic Adenocarcinoma ◽  
Endemic Region ◽  
Disc Space ◽  
Adenocarcinoma Of The Lung ◽  
Radiological Features ◽  
Vertebral Endplates ◽  
Distinguishing Features

Clinically, it is sometimes difficult to distinguish an infection of the spine from a metastasis. Spinal tuberculosis is common according to its endemic region and adenocarcinoma of the lung is also rising in the incidence worldwide. Similar presentations, with unknown primary, clinical findings and hematological investigations rarely conclude a true diagnosis. Radiologically, the hallmark of spinal infection is erosion of adjacent vertebral endplates and narrowing of the disc space with or without a paravertebral shadow. Metastasis typically does not involve the disc space with erosion of the adjacent vertebral endplates. It usually presents as a lytic/sclerotic lesion in the vertebral body or “winkle owl” sign. These distinguishing features of infection versus metastasis are not certainties. Biopsy is mandatory whenever in doubt or patient is not responded with provisional treatment. The author presents a case with so-called radiological features of spinal tuberculosis infection, which turns out to be a metastatic adenocarcinoma of the lung.

scholarly journals Risk factors and predictors for tumor site origin in metastatic adenocarcinoma of unknown primary site

2021 ◽  
Author(s):  
Xinrong Li ◽  
Yan Shao ◽  
Liqiang Sheng ◽  
Junquan Zhu ◽  
Zeming Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Site ◽  
Unknown Primary ◽  
Tumor Site ◽  
Metastatic Adenocarcinoma ◽  
Unknown Primary Site

Role of percutaneous transpedicular biopsy in diagnosis of spinal tuberculosis and its correlation with the clinico-radiological features

2019 ◽  
Vol 66 (3) ◽  
pp. 388-393 ◽  
Author(s):  
Madan Mohan Sahoo ◽  
Sudhir Kumar Mahapatra ◽  
Gopal Chandra Sethi ◽  
Anshuman Sahoo ◽  
Bikram Keshari Kar
Keyword(s):  
Spinal Tuberculosis ◽  
Radiological Features

Presumed disseminated carcinomatosis of the bone marrow in a dog

2020 ◽  
Vol 8 (3) ◽  
pp. e000979
Author(s):  
Bárbara Andreia Jardim Gomes ◽  
Eilidh Gunn ◽  
Caroline Millins ◽  
Elspeth M Waugh ◽  
Gawain Hammond
Keyword(s):  
Bone Marrow ◽  
Differential Diagnosis ◽  
Unknown Primary ◽  
Long Bones ◽  
Metastatic Adenocarcinoma ◽  
Elbow Pain ◽  
Asymmetrical Distribution ◽  
Primary Origin ◽  
Left Humerus ◽  
Unknown Primary Origin

An eight-year-old male neutered Jack Russell terrier presented with fever, shoulder and elbow pain and progressive right forelimb lameness. Haematology revealed a non-regenerative anaemia and marked thrombocytopenia. Radiography and CT of the thorax and abdomen revealed bilateral asymmetrical osteogenic-osteolytic changes to the scapulae, humeri, femurs, pelvis, ribs and vertebrae. Histopathology of the bone marrow of the left humerus confirmed a metastatic skeletal adenocarcinoma. This case features a presumptive manifestation of disseminated carcinomatosis of the bone marrow with a bilateral asymmetrical distribution in a metastatic adenocarcinoma of unknown primary origin. Disseminated carcinomatosis of the bone marrow should be included in the differential diagnosis with polyostotic osteolytic and osteogenic, bilateral asymmetrical lesions in the long bones, vertebrae, ribs and pelvis.

scholarly journals Imaging features of discospondylitis in cats

2019 ◽  
Vol 22 (7) ◽  
pp. 631-640 ◽  
Author(s):  
Sergio A Gomes ◽  
Sebastien Behr ◽  
Laurent S Garosi ◽  
Ines Carrera ◽  
Mike Targett ◽  
...  
Keyword(s):  
Contrast Enhancement ◽  
Imaging Features ◽  
Nerve Roots ◽  
Intervertebral Disc Space ◽  
Disc Space ◽  
Radiographic Findings ◽  
Mri Features ◽  
Vertebral Bodies ◽  
Vertebral Endplates ◽  
Short Tau Inversion Recovery

Objectives This study describes the imaging features of feline discospondylitis on MRI, comparing them with CT and radiographic findings where available. Methods The medical records of cats diagnosed with discospondylitis, presented to three referring institutions, were reviewed. MRI, CT and radiographic features were assessed by two of the authors independently. Results Fourteen sites of discospondylitis were retrospectively identified in 13 cats. The L7–S1 intervertebral disc space (IVDS) was affected in 7/14 (50%) cases. Characteristic MRI features included a hyperintense nucleus pulposus signal on T2-weighted (T2W) imaging (n = 10/14 [71%]) and short tau inversion recovery (STIR) imaging (n = 11/13 [85%]), with contrast enhancement in all (n = 11/11); involvement of adjacent vertebral endplates (n = 11/14 [79%]) and hyperintense neighbouring soft tissue on T2W (n = 11/14 [79%]) and STIR (n = 10/13 [77%]), with contrast enhancement in all (n = 11/11); and the presence of spondylosis deformans (n = 10/14 [71%]). Other features included narrowed or collapsed IVDS (n = 8/14 [57%]), contrast enhancement of vertebral bodies (n = 5/11 [46%]), epidural space involvement (n = 5/14 [36%]), compression of the spinal cord or nerve roots (n = 5/14 [36%]), paraspinal abscessation (n = 3/14 [21%]) and meningeal signal intensity abnormalities with contrast enhancement (n = 5/6 [83%]). These latter findings may indicate secondary focal meningitis. Radiographs were available covering five sites (in four cats) and CT covering three sites (in two cats). The most common radiological features were collapse or narrowing of the affected IVDS (80%) and endplate erosion (60%). No changes suggestive of discospondylitis were identifiable on radiography or CT in two sites (one cat), despite being identifiable on MRI. Repeated radiography in one case did not reveal complete radiological resolution following 9 months of treatment. Conclusions and relevance The results of this study indicate consistent MRI features of feline discospondylitis that should be considered in the diagnosis of this condition.

scholarly journals Hyperuricemic Renal Failure in Nonhematologic Solid Tumors: A Case Report and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Neeraj Saini ◽  
Kyeong Pyo Lee ◽  
Smita Jha ◽  
Sanket Patel ◽  
Neelima Bonthu ◽  
...  
Keyword(s):  
Solid Tumors ◽  
Tumor Lysis Syndrome ◽  
Cytotoxic Chemotherapy ◽  
Unknown Primary ◽  
Metastatic Adenocarcinoma ◽  
Review Of The Literature ◽  
Tumor Lysis ◽  
Hematological Cancers ◽  
Spontaneous Tumor Lysis Syndrome ◽  
Tumor Cell Lysis

Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by massive tumor cell lysis. It is commonly associated with hematological cancers like leukemia and lymphoma and uncommonly with solid nonhematologic tumors as well. However, spontaneous tumor lysis syndrome (STLS) without any cytotoxic chemotherapy rarely occurs in solid tumors. We describe a case of STLS in a metastatic adenocarcinoma of unknown primary and review the literature of STLS in solid non-hematologic tumors to identify various risk factors for pathogenesis of this entity.

scholarly journals Fallopian tube cancer incidentally diagnosed during laparoscopy for metastatic adenocarcinoma of unknown primary lesion

2016 ◽  
Vol 5 (4) ◽  
pp. 166-169
Author(s):  
Mayumi Takano ◽  
Yukiko Kagawa ◽  
Susumu Murata ◽  
Michihisa Fujiwara ◽  
Masahiko Nakata ◽  
...  
Keyword(s):  
Fallopian Tube ◽  
Primary Lesion ◽  
Unknown Primary ◽  
Metastatic Adenocarcinoma ◽  
Fallopian Tube Cancer
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