scholarly journals Treatment Options for Colorectal Cancer Liver Metastases

2020 ◽  
pp. 1-6
Author(s):  
Zhiming Zhao ◽  
Mengyang Li ◽  
Xianglong Tan ◽  
Zhiming Zhao
Keyword(s):  
Colorectal Cancer ◽  
Liver Transplantation ◽  
Liver Metastases ◽  
Immune Therapy ◽  
Treatment Options ◽  
Common Site ◽  
Colorectal Cancer Liver Metastases ◽  
Treatment Indications ◽  
Tremendous Progress ◽  
Selection Of

The liver is the most common site of metastasis in colorectal cancer (CRC). Treatment of liver metastases determines the prognosis of patients with CRC. Tremendous progress has been made during the last two decades, which has greatly improved the overall survival of CRC patients. Currently, various treatment options are available, including hepatectomy, liver transplantation, local regional therapy, chemotherapy, targeted therapy, and immune therapy, inevitably leading to some controversies on treatment indications and selection of treatment strategy. Here, we reviewed the existing approaches to treat colorectal cancer liver metastases, with the aim of examining several crucial questions regarding surgical resection, liver transplantation, and medical treatment in clinical practice.

scholarly journals Is post‐transplant chemotherapy feasible in liver transplantation for colorectal cancer liver metastases?

2020 ◽  
Vol 40 (9) ◽  
pp. 461-464
Author(s):  
Giovanni Brandi ◽  
Angela Dalia Ricci ◽  
Alessandro Rizzo ◽  
Chiara Zanfi ◽  
Simona Tavolari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Transplantation ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Post Transplant

Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases

2015 ◽  
Vol 262 (1) ◽  
pp. e12 ◽  
Author(s):  
Paulo Ney Aguiar Martins ◽  
Babak Movahedi ◽  
Adel Bozorgzadeh
Keyword(s):  
Colorectal Cancer ◽  
Liver Transplantation ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases

The Role of Liver Transplantation for Liver Metastasis from Colorectal Cancer

2020 ◽  
Vol 04 (01) ◽  
pp. 013-018
Author(s):  
Koji Tomiyama ◽  
M. Katherine Dokus ◽  
Jennie Errigo ◽  
Marie Laryea ◽  
Roberto Hernandez-Alejandro
Keyword(s):  
Colorectal Cancer ◽  
Liver Transplantation ◽  
Liver Metastases ◽  
Surgical Resection ◽  
Liver Volume ◽  
Remnant Liver ◽  
Colorectal Cancer Liver Metastases ◽  
Term Survival ◽  
Long Term Survival

AbstractAs chemotherapy for colorectal cancer becomes effective for extending long-term survival, its liver metastases (colorectal cancer liver metastases [CRCLM]) are considered as the progression that best defines patient survival. Surgical resection is the most effective and only curative treatment for CRCLM. Although advancement in liver surgery to increase resectability of CRCLM has borne fruit, there are still limitations, namely tumor burden, remnant liver volume, and chemotherapy-related liver damage. CRCLM used to be considered a contraindication for liver transplantation (LTx) based on preliminary experience in the early era of LTx. Recent advancement in chemotherapy and surgical resection for CRCLM as well as improved outcome of LTx have attracted interest in revisiting this old dogma of LTx for CRCLM. Preliminary experience from Norway has shown promising results and potential for long-term survival with LTx. In this article, we review the history of LTx for CRCLM, rationale for revisiting the concept, early experience from Norway and discuss the issues around and future perspectives on LTx for CRCLM.

scholarly journals Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancer

2020 ◽  
Vol 37 (6) ◽  
pp. 649-656
Author(s):  
Hannah Voß ◽  
Marcus Wurlitzer ◽  
Daniel J. Smit ◽  
Florian Ewald ◽  
Malik Alawi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Extracellular Matrix ◽  
Liver Metastases ◽  
Surgical Resection ◽  
Treatment Options ◽  
Single Patient ◽  
Poor Overall Survival ◽  
Colorectal Cancer Liver Metastases ◽  
The Third ◽  
Molecular Features

AbstractColorectal cancer (CRC) patients suffer from the second highest mortality among all cancer entities. In half of all CRC patients, colorectal cancer liver metastases (CRLM) can be observed. Metastatic colorectal cancer is associated with poor overall survival and limited treatment options. Even after successful surgical resection of the primary tumor, metachronous liver metastases occur in one out of eight cases. The only available curative intended treatment is hepatic resection, but metachronous CRLM frequently recur after approximately 1 year. In this study, we performed a proteome analysis of three recurrent liver metastases of a single CRC patient by mass spectrometry. Despite surgical resection of the primary CRC and adjuvant chemotherapy plus cetuximab treatment, the patient developed three metachronous CRLM which occurred consecutively after 9, 21 and 31 months. We identified a set of 1132 proteins expressed in the three metachronous CRLM, of which 481 were differentially regulated, including 81 proteins that were associated with the extracellular matrix (ECM). 56 ECM associated proteins were identified as upregulated in the third metastasis, 26 (46%) of which were previously described as negative prognostic markers in CRC, including tenascin C, nidogen 1, fibulin 1 and vitronectin. These data may reflect an ascending trend of malignancy from the first to the third metachronous colorectal cancer liver metastasis. Additionally, the results indicate different ECM phenotypes for recurrent metachronous metastasis, associated with different grades of malignancy and highlights the importance of individual analysis of molecular features in different, consecutive metastatic events in a single patient.

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