Lynch Syndrome and Breast Cancer: Case Reports and Literature Review

2020 ◽  
pp. 1-3
Author(s):  
Spyridon Marinopoulos ◽  
Spyridon Marinopoulos ◽  
Eleni Papamattheou ◽  
Sofia-Dionysia Touriki ◽  
Aris Giannos ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lynch Syndrome ◽  
Hereditary Cancer ◽  
Cancer Genomics ◽  
Case Reports ◽  
Breast Cancer Case ◽  
Cancer Case ◽  
Inherited Disease ◽  
Cancer Mutations ◽  
History Of

In the era of advanced cancer genomics, our knowledge of hereditary cancer mutations continues to expand. Lynch syndrome is one of the hereditary cancer predisposition syndromes associated with an increased lifelong risk of several types of cancer development, such as colorectal, endometrial, ovarian and other. This unique syndrome is an autosomal dominant inherited disease caused by mutations on EPCAM gene or on mismatch repair genes, which lead to microsatellite instability. In this article we will present three such cases visiting our clinic. They had breast cancer and a familial or personal history of malignancy. This article summarizes what we consider important about Lynch syndrome and breast cancer.

scholarly journals Thyroid gland metastasis from breast cancer: A rare case report and literature overview

2018 ◽  
Vol 146 (7-8) ◽  
pp. 466-469 ◽  
Author(s):  
Zorka Inic ◽  
Aleksandar Martinovic ◽  
Momcilo Inic ◽  
Dijana Pilcevic ◽  
Gordana Pupic
Keyword(s):  
Breast Cancer ◽  
Thyroid Gland ◽  
Rare Case ◽  
Metastatic Breast ◽  
Breast Cancer Case ◽  
Left Breast ◽  
Cancer Case ◽  
Thyroid Lesion ◽  
Metastatic Breast Carcinoma ◽  
History Of

Introduction. The thyroid gland is a rare site for metastatic lesions from non-thyroid cancers. Due to the fact that achieving a diagnosis of thyroid gland metastasis from breast cancer prior to operation is challenging, the diagnosis thereof is mainly based on a pathological biopsy and immunohistochemical staining. The aim of this study was to present a rare case of thyroid gland metastasis from lobular breast cancer. Case outline. The patient was a 33-year-old female who had already had a five-year history of lobular cancer of the right breast and was thereafter found to have two suspicious tumors in the left breast, as well as a thyroid mass diagnosed as metastatic breast carcinoma. Conclusion. Patients who have a thyroid lesion and a history of malignancy are at a higher risk for metastasis and require additional caution during diagnosis and treatment.

Pseudocirrhosis after chemotherapy in breast cancer, case reports

Breast Cancer ◽  
2018 ◽  
Vol 25 (5) ◽  
pp. 614-618 ◽  
Author(s):  
Tomoyoshi Aoyagi ◽  
Kazuaki Takabe ◽  
Tamaki Tamanuki ◽  
Hisahiro Matsubara ◽  
Hiroshi Matsuzaki
Keyword(s):  
Breast Cancer ◽  
Case Reports ◽  
Breast Cancer Case ◽  
Cancer Case

scholarly journals Intrathecal Methotrexate and Craniospinal Radiotherapy Can Be an Effective Treatment of Carcinomatous Meningitis in Patients with Breast Cancer: Case Reports

2016 ◽  
Vol 9 (3) ◽  
pp. 586-592 ◽  
Author(s):  
Magdalena Meissner ◽  
Alfredo Addeo
Keyword(s):  
Breast Cancer ◽  
Case Reports ◽  
Breast Cancer Case ◽  
Intrathecal Methotrexate ◽  
Cancer Case ◽  
Carcinomatous Meningitis ◽  
Breast Cancer Patients ◽  
Similar Treatment ◽  
Craniospinal Radiotherapy ◽  
Sequential Combination

Introduction: Carcinomatous meningitis in breast cancer occurs as a complication in up to 5% of all cases. It is a very devastating diagnosis, with a median patient survival of about 3 months. Treatment is very controversial, and different modalities of treatment have been used but none of them show significant benefit for overall survival. Case Reports: We report 2 cases of carcinomatous meningitis in breast cancer patients. They received a similar treatment of a combination of intrathecal (IT) methotrexate followed by craniospinal radiotherapy. Both patients survived for many years after treatment and are in complete clinical and radiological remission. Conclusion: Meningeal metastasis from breast cancer can be very effectively treated with IT and/or systemic chemotherapy followed by craniospinal radiotherapy. Further studies are needed to determine the effectiveness of this sequential combination of chemotherapy with radiotherapy.

scholarly journals Interdisciplinary Management of Transgender Individuals at Risk for Breast Cancer: Case Reports and Review of the Literature

2019 ◽  
Vol 19 (1) ◽  
pp. e12-e19 ◽  
Author(s):  
Julia Eismann ◽  
Yujing J. Heng ◽  
Kristin Fleischmann-Rose ◽  
Adam M. Tobias ◽  
Jordana Phillips ◽  
...  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Case Reports ◽  
Breast Cancer Case ◽  
Cancer Case ◽  
Interdisciplinary Management ◽  
Review Of The Literature

Intermittent Letrozole Therapy for Metastatic Breast Cancer: Case Reports and Literature Review

2014 ◽  
Vol 14 (2) ◽  
pp. e41-e45 ◽  
Author(s):  
Lei Fan ◽  
Pedro E.R. Liedke ◽  
Steven J. Isakoff ◽  
Jessica St Louis ◽  
Paula D. Ryan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Literature Review ◽  
Case Reports ◽  
Metastatic Breast ◽  
Breast Cancer Case ◽  
Cancer Case

Acute Myeloblastic Leukemia after Adjuvant Chemotherapy with Melphalan in Breast Cancer. Case Report with Cytogenetic Analysis

1983 ◽  
Vol 69 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Stefania Gori ◽  
Emilio Donti ◽  
Giovanna Venti ◽  
Cristina Mecucci ◽  
Lucio Crinò ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cytogenetic Analysis ◽  
Alkylating Agents ◽  
Breast Cancer Case ◽  
Underlying Disease ◽  
Lymphocytic Leukemia ◽  
Cancer Case ◽  
Genetic Damage ◽  
History Of ◽  
Group A

Therapy of solid and hematologic tumors with alkylating agents appears to increase the frequency of acute non-lymphocytic leukemia (ANLL), as indicated by the cases reported in the literature. The carcinogenetic mechanism of alkylating agents seems related to their ability to damage DNA, and this is supported by the findings of multiple cytogenetic abnormalities in these patients. We report a case of ANLL secondary to therapy with melphalan, which was utilized on an adjuvant basis for breast cancer. ANLL developed 24 months after chemotherapy was discontinued. Results of the cytogenetic analysis in our patient showed multiple rearrangements and marker chromosomes. Among these was a large metacentric chromosome, identified in 6 of 8 karyotypes, in the size range of group A, which probably resulted from a translocation t(7;14) (7qter→7p11::14p11-→14qter). The natural history of the underlying disease and of the ANLL in our patient and data from chromosomal analysis seem to confirm the hypothesis that alkylating agents are potentially leukemogenic in man, probably through genetic damage. This possibility should be considered when such cytotoxic drugs are used in an adjuvant setting.

scholarly journals Experience with ospemifene in patients with vulvar and vaginal atrophy and a history of breast cancer: case studies

2020 ◽  
Vol 9 ◽  
pp. 1-6
Author(s):  
Mariella Lilue ◽  
Santiago Palacios ◽  
María del Carmen Pingarrón Santofimia
Keyword(s):  
Breast Cancer ◽  
Case Studies ◽  
Breast Cancer Case ◽  
Cancer Case ◽  
Vaginal Atrophy ◽  
History Of

scholarly journals Pseudocirrhosis after the Use of Taxanes and Bevacizumab in Metastatic Breast Cancer: Case Reports

2017 ◽  
Vol 5 (3) ◽  
Author(s):  
Gabriel Lima Lopes ◽  
Bruna Migliavacca Zucchetti ◽  
Juliana Florinda de Mendoça Rego ◽  
Daniela de Freitas ◽  
Ricardo José Marques
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Case Reports ◽  
Metastatic Breast ◽  
Breast Cancer Case ◽  
Cancer Case
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