scholarly journals Experience with ospemifene in patients with vulvar and vaginal atrophy and a history of breast cancer: case studies

2020 ◽  
Vol 9 ◽  
pp. 1-6
Author(s):  
Mariella Lilue ◽  
Santiago Palacios ◽  
María del Carmen Pingarrón Santofimia
2018 ◽  
Vol 14 (7s) ◽  
pp. 13-20 ◽  
Author(s):  
Maria Isabel Gallegos Sancho ◽  
Raúl Márquez-Vázquez ◽  
Alfonso Sánchez-Muñoz

2018 ◽  
Vol 146 (7-8) ◽  
pp. 466-469 ◽  
Author(s):  
Zorka Inic ◽  
Aleksandar Martinovic ◽  
Momcilo Inic ◽  
Dijana Pilcevic ◽  
Gordana Pupic

Introduction. The thyroid gland is a rare site for metastatic lesions from non-thyroid cancers. Due to the fact that achieving a diagnosis of thyroid gland metastasis from breast cancer prior to operation is challenging, the diagnosis thereof is mainly based on a pathological biopsy and immunohistochemical staining. The aim of this study was to present a rare case of thyroid gland metastasis from lobular breast cancer. Case outline. The patient was a 33-year-old female who had already had a five-year history of lobular cancer of the right breast and was thereafter found to have two suspicious tumors in the left breast, as well as a thyroid mass diagnosed as metastatic breast carcinoma. Conclusion. Patients who have a thyroid lesion and a history of malignancy are at a higher risk for metastasis and require additional caution during diagnosis and treatment.


1983 ◽  
Vol 69 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Stefania Gori ◽  
Emilio Donti ◽  
Giovanna Venti ◽  
Cristina Mecucci ◽  
Lucio Crinò ◽  
...  

Therapy of solid and hematologic tumors with alkylating agents appears to increase the frequency of acute non-lymphocytic leukemia (ANLL), as indicated by the cases reported in the literature. The carcinogenetic mechanism of alkylating agents seems related to their ability to damage DNA, and this is supported by the findings of multiple cytogenetic abnormalities in these patients. We report a case of ANLL secondary to therapy with melphalan, which was utilized on an adjuvant basis for breast cancer. ANLL developed 24 months after chemotherapy was discontinued. Results of the cytogenetic analysis in our patient showed multiple rearrangements and marker chromosomes. Among these was a large metacentric chromosome, identified in 6 of 8 karyotypes, in the size range of group A, which probably resulted from a translocation t(7;14) (7qter→7p11::14p11-→14qter). The natural history of the underlying disease and of the ANLL in our patient and data from chromosomal analysis seem to confirm the hypothesis that alkylating agents are potentially leukemogenic in man, probably through genetic damage. This possibility should be considered when such cytotoxic drugs are used in an adjuvant setting.


2020 ◽  
pp. 1-3
Author(s):  
Spyridon Marinopoulos ◽  
Spyridon Marinopoulos ◽  
Eleni Papamattheou ◽  
Sofia-Dionysia Touriki ◽  
Aris Giannos ◽  
...  

In the era of advanced cancer genomics, our knowledge of hereditary cancer mutations continues to expand. Lynch syndrome is one of the hereditary cancer predisposition syndromes associated with an increased lifelong risk of several types of cancer development, such as colorectal, endometrial, ovarian and other. This unique syndrome is an autosomal dominant inherited disease caused by mutations on EPCAM gene or on mismatch repair genes, which lead to microsatellite instability. In this article we will present three such cases visiting our clinic. They had breast cancer and a familial or personal history of malignancy. This article summarizes what we consider important about Lynch syndrome and breast cancer.


OALib ◽  
2017 ◽  
Vol 04 (07) ◽  
pp. 1-4
Author(s):  
Zaied Sonia ◽  
Khechine Wiem ◽  
Abbess Ibtissem ◽  
Amina Ben Salem ◽  
Aloui Salma ◽  
...  

2018 ◽  
Vol 14 (7s) ◽  
pp. 21-27 ◽  
Author(s):  
Maria Lomas Garrido ◽  
Ana Jaén Morago ◽  
Pedro Sánchez Rovira ◽  
Paula Espinosa Olarte ◽  
Cristina Pernaut Sánchez ◽  
...  

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