Intrathecal Methotrexate and Craniospinal Radiotherapy Can Be an Effective Treatment of Carcinomatous Meningitis in Patients with Breast Cancer: Case Reports

Introduction: Carcinomatous meningitis in breast cancer occurs as a complication in up to 5% of all cases. It is a very devastating diagnosis, with a median patient survival of about 3 months. Treatment is very controversial, and different modalities of treatment have been used but none of them show significant benefit for overall survival. Case Reports: We report 2 cases of carcinomatous meningitis in breast cancer patients. They received a similar treatment of a combination of intrathecal (IT) methotrexate followed by craniospinal radiotherapy. Both patients survived for many years after treatment and are in complete clinical and radiological remission. Conclusion: Meningeal metastasis from breast cancer can be very effectively treated with IT and/or systemic chemotherapy followed by craniospinal radiotherapy. Further studies are needed to determine the effectiveness of this sequential combination of chemotherapy with radiotherapy.

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A Substantial Response from Adding Palbociclib to Endocrine Therapy in Brain Metastasis from Hormone Receptor-Positive, HER2-Negative Breast Cancer: Case Reports

Case Reports in Oncology ◽

10.1159/000514190 ◽

2021 ◽

pp. 446-452

Author(s):

Atlal Abusanad ◽

Hashem Al Hashem

Keyword(s):

Breast Cancer ◽

Brain Metastasis ◽

Endocrine Therapy ◽

Hormone Receptor ◽

Case Reports ◽

Growth Factor Receptor ◽

Breast Cancer Case ◽

Current Data ◽

Cancer Case ◽

Breast Cancer Patients

Brain metastasis (BM) from breast cancer has poor prognosis despite new advances and multi-modality treatments. No current data is guiding the use of palbociclib in the management of hormone receptor (HR)-positive breast cancer patients with BM as these patients were excluded systematically from all phase 3 trials. Here, we report an evident clinical response from combining palbociclib with endocrine therapy in HR-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer with BM.

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Pseudocirrhosis after chemotherapy in breast cancer, case reports

Breast Cancer ◽

10.1007/s12282-018-0865-5 ◽

2018 ◽

Vol 25 (5) ◽

pp. 614-618 ◽

Cited By ~ 1

Author(s):

Tomoyoshi Aoyagi ◽

Kazuaki Takabe ◽

Tamaki Tamanuki ◽

Hisahiro Matsubara ◽

Hiroshi Matsuzaki

Keyword(s):

Breast Cancer ◽

Case Reports ◽

Breast Cancer Case ◽

Cancer Case

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Diagnostic value of enhanced computed tomography in the detection of the widely spreading intraductal component of breast cancer: Case reports

Breast Cancer ◽

10.1007/bf02967052 ◽

1997 ◽

Vol 4 (1) ◽

pp. 29-32 ◽

Cited By ~ 12

Author(s):

Sadako Akashi-Tanaka ◽

Takashi Fukutomi ◽

Kunihisa Miyakawa ◽

Hitoshi Tsuda

Keyword(s):

Breast Cancer ◽

Computed Tomography ◽

Case Reports ◽

Breast Cancer Case ◽

Diagnostic Value ◽

Cancer Case ◽

Intraductal Component ◽

Enhanced Computed Tomography

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Interdisciplinary Management of Transgender Individuals at Risk for Breast Cancer: Case Reports and Review of the Literature

Clinical Breast Cancer ◽

10.1016/j.clbc.2018.11.007 ◽

2019 ◽

Vol 19 (1) ◽

pp. e12-e19 ◽

Cited By ~ 12

Author(s):

Julia Eismann ◽

Yujing J. Heng ◽

Kristin Fleischmann-Rose ◽

Adam M. Tobias ◽

Jordana Phillips ◽

...

Keyword(s):

Breast Cancer ◽

At Risk ◽

Case Reports ◽

Breast Cancer Case ◽

Cancer Case ◽

Interdisciplinary Management ◽

Review Of The Literature

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Successful Use of Biweekly Gemcitabine Plus Nab-Paclitaxel in Two Male Patients With Stage IV Breast Cancer: Case Reports and Review of the Literature

American Journal of Therapeutics ◽

10.1097/mjt.0b013e3181c219e2 ◽

2011 ◽

Vol 18 (1) ◽

pp. e12-e18 ◽

Cited By ~ 1

Author(s):

Alberto J Montero ◽

Tony N Talebi ◽

Ying Zhu ◽

Kevin D Branch ◽

Grant T Goldsberry ◽

...

Keyword(s):

Breast Cancer ◽

Case Reports ◽

Stage Iv ◽

Breast Cancer Case ◽

Cancer Case ◽

Review Of The Literature ◽

Stage Iv Breast Cancer ◽

Male Patients

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Intermittent Letrozole Therapy for Metastatic Breast Cancer: Case Reports and Literature Review

Clinical Breast Cancer ◽

10.1016/j.clbc.2013.10.009 ◽

2014 ◽

Vol 14 (2) ◽

pp. e41-e45 ◽

Cited By ~ 2

Author(s):

Lei Fan ◽

Pedro E.R. Liedke ◽

Steven J. Isakoff ◽

Jessica St Louis ◽

Paula D. Ryan ◽

...

Keyword(s):

Breast Cancer ◽

Metastatic Breast Cancer ◽

Literature Review ◽

Case Reports ◽

Metastatic Breast ◽

Breast Cancer Case ◽

Cancer Case

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Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects

International Journal of Differential Equations ◽

10.1155/2021/3401639 ◽

2021 ◽

Vol 2021 ◽

pp. 1-8

Author(s):

M. Ivan Ariful Fathoni ◽

Fajar Adi-Kusumo ◽

Gunardi Gunardi ◽

Susanna Hilda Hutajulu

Keyword(s):

Breast Cancer ◽

Cancer Patients ◽

Interaction Model ◽

Breast Cancer Case ◽

The Body ◽

Cancer Case ◽

Dimensional System ◽

Breast Cancer Patients ◽

Dimensional Parameter ◽

Chemotherapy Drugs

Breast cancer is a type of carcinoma with a high prevalence. The treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. The neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapy-induced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. In this paper, we introduce an interaction model between blood components, i.e., neutrophil, lymphocytes, and albumin, with chemotherapy drugs. The model is important to understand the neutropenia effect due to chemotherapy in mathematical perspective and to calculate breast cancer patients’ survival level. Our model is a four-dimensional system of the first-order ODE with 13-dimensional parameter space. We focus our study for understanding the steady-state conditions and the bifurcations when the parameter values are varied. Here, we also study the role of albumin for reducing the neutropenia effects for breast cancer patients mathematically, where the results can be used as an alternative solution for treating neutropenia in a breast cancer case.

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Lynch Syndrome and Breast Cancer: Case Reports and Literature Review

Surgical Case Reports ◽

10.31487/j.scr.2020.09.15 ◽

2020 ◽

pp. 1-3

Author(s):

Spyridon Marinopoulos ◽

Eleni Papamattheou ◽

Sofia-Dionysia Touriki ◽

Aris Giannos ◽

...

Keyword(s):

Breast Cancer ◽

Lynch Syndrome ◽

Hereditary Cancer ◽

Cancer Genomics ◽

Case Reports ◽

Breast Cancer Case ◽

Cancer Case ◽

Inherited Disease ◽

Cancer Mutations ◽

History Of

In the era of advanced cancer genomics, our knowledge of hereditary cancer mutations continues to expand. Lynch syndrome is one of the hereditary cancer predisposition syndromes associated with an increased lifelong risk of several types of cancer development, such as colorectal, endometrial, ovarian and other. This unique syndrome is an autosomal dominant inherited disease caused by mutations on EPCAM gene or on mismatch repair genes, which lead to microsatellite instability. In this article we will present three such cases visiting our clinic. They had breast cancer and a familial or personal history of malignancy. This article summarizes what we consider important about Lynch syndrome and breast cancer.

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A Comparative Study of Two In Vivo PET Verification Methods in Clinical Cases

Frontiers in Oncology ◽

10.3389/fonc.2021.617787 ◽

2021 ◽

Vol 11 ◽

Author(s):

Junyu Zhang ◽

Yan Lu ◽

Yinxiangzi Sheng ◽

Weiwei Wang ◽

Zhengshan Hong ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Case ◽

Mean Value ◽

Cancer Case ◽

Breast Cancer Patients ◽

Verification Methods ◽

Significant Difference ◽

The Mean ◽

Clinical Cases

PurposePositron emission tomography (PET) range verification is an important method that can help improve the confidence in proton therapy for clinical applications. Two kinds of verification methods are implemented and compared based on clinical cases in this study.MethodThe study is conducted on 14 breast cancer patients following proton irradiation treatment. Verification is done by calculating the depth error between the numerically predicted values with the measured PET image along the beam direction. Point-based and segment-based methods are applied and compared. The verification results are presented as depth error means and standard deviations in a region of interest (ROI).ResultsThe mean value of the depth error of all 14 cases is within the range of [−3, 3] mm for both point-based and segment-based methods, and only one case result calculated by the point-based method is slightly beyond −3 mm. When comparing the mean depth error from the two methods, the paired t-test result shows that the p-value is 0.541, and the standard deviation of the segment-based method is smaller than that of the point-based method.ConclusionIn breast cancer case verification application, point-based and segment-based methods show no significant difference in the mean value of results. Both methods can quantify the accuracy of proton radiotherapy to the millimeter level.

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