Validation of the LiverFASt Test and the Associated Fibrosis Staging Scores Compared to Liver Tissue Pathology Via Liver Biopsy

2019 ◽  
Author(s):  
Keyword(s):  
Liver Biopsy ◽  
Liver Tissue ◽  
Fibrosis Staging

scholarly journals LIVER BIOPSY

2011 ◽  
Vol 18 (04) ◽  
pp. 709-714
Author(s):  
FUAD AHMAD SIDDIQI ◽  
RIZWANA KITCHLEW ◽  
ASIF HASHMI
Keyword(s):  
Liver Biopsy ◽  
Liver Tissue ◽  
Blood Donors ◽  
Carrier State ◽  
Military Hospital ◽  
Histopathologic Diagnosis ◽  
Right Lobe ◽  
The Mean ◽  
One Year ◽  
Made In

Objective: To study the safety and efficacy of Surecut needle in obtaining the liver tissue by percutaneous liver biopsy. Design: Single centered prospective hospital based study. Place and duration of study: Department of Internal medicine (Unit-1) & Family ward, Combined military hospital Lahore for more than one year from August 2002 to March 2004. Materials and Methods: One hundred and fifty patients of either gender having asymptomatic hepatitis C carrier state, healthy blood donors, with positive HCV-PCR were included in study. The patients liver biopsy was done with Surecut needle 16G with patient breath suspended in expiration from the periphery of right lobe of liver. Result: Majority of patients, 135 ( 90% ) were male and 15 (10%) were female. The mean age was 30.3 years with range of 25-55years. In 146(97.31%)patients successful biopsy was done while the biopsy was non-diagnostic in 4(2.69%) patients. Mean core length of liver tissue obtained was Mean+sd(1.2+0.42cm) and histopathologic diagnosis was made in 97.31% cases. Total number of attempts were 1-2. In 99% single attempt was done. No major complications related to procedure was seen. Conclusions: liver biopsy with Surecut needle is safe and effective in establishing the diagnosis of Chronic hepatitis.

scholarly journals REAL-TIME ELASTOGRAPHY AND ITS CLINICAL APPLICATION COMPARED WITH OTHER METHODS FOR EVALUATION OF THE LIVER FIBROSIS DEGREE IN PATIENTS WITH CHRONIC HEPATITIS C

2018 ◽  
Vol 10 (3) ◽  
pp. 84-90
Author(s):  
M. A. Belopolskaya ◽  
V. Yu. Avrutin ◽  
O. D. Denisova ◽  
E. V. Lichnaya ◽  
E. Yu. Yushina ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Liver Tissue ◽  
Transient Elastography ◽  
Alternative Methods ◽  
Saint Petersburg ◽  
The One ◽  
Severe Fibrosis

In this work we investigated to which extent the evaluation results of the degree of hepatic fibrosis obtained by realtime elastography (RTE) method are compatible with the results of the transient elastography (TE) and with the APRI indexes. We also analyzed the factors which can influence the reliability of the fibrosis degree evaluation obtained by different methods.Materials and methods. The study included 99 patients (60 women and 39 men) with HCV, examined in the polyclinic department of the Saint-Petersburg Botkin clinical infectious hospital in 2017. In 83 patients, the fibrosis degree in the liver tissue has been evaluated by the RTE method using HI VISION Preirus (Hitachi, Japan) with a linear sensor. In 67 patients, the evaluation has been performed by the TE method using Fibroscan (Echosens, France). Both methods have been applied to 51 patients.Conclusions. The aplication results of the RTE and TE methods do not differ significantly for patients with a severe fibrosis. Usually, the degree of fibrosis in patients with CHC obtained by the RTE is higher than the one obtained by the TE in the same patient. Due to the possibility to visualize a larger area under study, the RTE method has clear advantages in evaluating the degree of fibrosis in liver tissue in patients with focal changes in the liver. If the results obtained by the RTE and TE methods differ significantly, alternative methods must be used, such as a liver biopsy and biochemical methods.

Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe

2012 ◽  
Vol 56 (3) ◽  
pp. 564-570 ◽  
Author(s):  
Robert P. Myers ◽  
Gilles Pomier-Layrargues ◽  
Richard Kirsch ◽  
Aaron Pollett ◽  
Melanie Beaton ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Transient Elastography ◽  
Fibrosis Staging

Magnetic resonance elastography is as accurate as liver biopsy for liver fibrosis staging

2017 ◽  
Vol 47 (5) ◽  
pp. 1268-1275 ◽  
Author(s):  
Hiroyuki Morisaka ◽  
Utaroh Motosugi ◽  
Shintaro Ichikawa ◽  
Tadao Nakazawa ◽  
Tetsuo Kondo ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Magnetic Resonance Elastography ◽  
Fibrosis Staging

scholarly journals Medical liver biopsy: background, indications, procedure and histopathology

2019 ◽  
Vol 11 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Alexander Boyd ◽  
Owen Cain ◽  
Abhishek Chauhan ◽  
Gwilym James Webb
Keyword(s):  
Liver Biopsy ◽  
Liver Tissue ◽  
Histological Analysis ◽  
Histological Images ◽  
Selection Of

Histological analysis of liver tissue continues to play an important role in modern hepatological practice. This review explores the indications for medical liver biopsy in addition to the procedure itself, potential complications, preparation of tissue and routine staining. A broad selection of histological images is included to illustrate the appearance of liver tissue both in health and in several important diseases.

2092099 The Quality of Liver Tissue Specimen in Echo-Assisted Liver Biopsy

2015 ◽  
Vol 41 (4) ◽  
pp. S170
Author(s):  
Ioan Sporea ◽  
Felix Bende ◽  
Roxana Sirli ◽  
Alina Popescu ◽  
Silviu Nistorescu
Keyword(s):  
Liver Biopsy ◽  
Liver Tissue ◽  
Tissue Specimen

The Microheterogeneity of Human Liver and Serum Ferritins Measured on Minute Amounts of Ferritin in Crude Samples

1984 ◽  
Vol 21 (6) ◽  
pp. 471-476 ◽  
Author(s):  
F M J Zuyderhoudt ◽  
C Linthorst
Keyword(s):  
Liver Biopsy ◽  
Iron Overload ◽  
Liver Tissue ◽  
Biopsy Specimen ◽  
Unknown Origin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Liver Biopsy Specimen ◽  
Tissue Samples ◽  
Ferritin Concentration ◽  
Biopsy Specimens

A method is presented to measure the microheterogeneity of ferritin in μg amounts, without purifying the samples extensively. Ferritin-containing samples such as serum and homogenized liver-biopsy specimens were mixed with Sephadex G-75 and ampholines. Isoelectric focussing was performed and the pH gradient in the Sephadex was measured. The Sephadex was divided into predetermined pH ranges and the ferritin eluted from these fractions. Ferritin concentration was measured by an enzyme-linked immunosorbent assay. The method proved to be reproducible. The isoferritin profiles of different human serum and liver tissue samples were quite variable. In most cases serum ferritins focussed between approximately pH 5·5 and pH 4·9 and liver ferritins between approximately pH 5·8 and pH 5·3. We examined whether there was a similarity in the isoferritin patterns of serum and liver of distinct patients. We also studied liver tissue and serum from a patient with haemochromatosis and from a child with iron overload of unknown origin. In the serum of our patients the isoferritin pattern had shifted to lower pI when compared with that found in liver tissue. Only in the case of a patient with transfusion iron overload were basic isoferritins measured in the serum. In this case no liver biopsy specimen was available for comparison.

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