Study of Ampion for the Treatment of Pain and Function in Patients With Severe Osteoarthritis of the Knee.

Objective To determine the effectiveness of acupuncture treatment for pain and function of patients with osteoarthritis of the knee. Methods A systematic review of randomised controlled trials was performed, including a meta-analysis which combined the results of trials that used adequate acupuncture treatment and used WOMAC scores to measure the effect. The internal validity (quality) and heterogeneity of studies were taken into account. Results Thirteen studies were available, of which eight, involving 2362 patients, could be combined. For both reduction of pain and improvement of function, acupuncture was significantly superior to sham acupuncture (P<0.05 for all comparisons) in both the short term and the long term. Compared with no additional intervention (usual care), acupuncture was again significantly superior for pain and function. The treatment effects were maintained after taking account of quality and heterogeneity in sensitivity analyses. Conclusion Acupuncture is an effective treatment for osteoarthritis of the knee. Its overall effect size is 0.8, and it can be considered instead of non-steroidal anti-inflammatory drugs for patients whose symptoms are not controlled by education, exercise, weight loss if appropriate and simple analgesics. Further research is necessary into the most efficient way of delivering acupuncture, and its longer term benefits.

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The dietary supplement collagen hydrolysate may improve pain and function in osteoarthritis of the knee,

Inpharma Weekly ◽

10.2165/00128413-200414670-00019 ◽

2004 ◽

Vol &NA; (1467) ◽

pp. 9

Author(s):

&NA;

Keyword(s):

Dietary Supplement ◽

Osteoarthritis Of The Knee ◽

Collagen Hydrolysate ◽

And Function

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The Effects of Morus alba and Acacia catechu on Quality of Life and Overall Function in Adults with Osteoarthritis of the Knee

Journal of Nutrition and Metabolism ◽

10.1155/2017/4893104 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 6

Author(s):

Douglas S. Kalman ◽

Susan J. Hewlings

Keyword(s):

Cartilage Damage ◽

Type Ii Collagen ◽

Cartilage Degradation ◽

Morus Alba ◽

Osteoarthritis Of The Knee ◽

Significant Difference ◽

Womac Questionnaire ◽

Acacia Catechu ◽

Double Blinded ◽

And Function

The purpose of this study was to determine the effects of UP1306 on discomfort and function in adults with osteoarthritis of the knee. In a randomized, double-blinded, placebo-controlled, parallel design, 135 subjects received UP1306, a standardized, proprietary extract of Morus alba and Acacia catechu, glucosamine chondroitin, or placebo for 12 weeks. Discomfort, stiffness, and activities of daily living measured by the WOMAC questionnaire and VAS (pain/discomfort) were improved within all groups. Range of motion and distance walked were improved. There were no changes in TNFα levels for any of the products. There was a significant difference in urinary C-telopeptides of type II collagen (CTX-II), a marker of cartilage degradation between UP1306, and placebo after 12 weeks (p=0.029). All efficacy measurements were improved from baseline to most time-points for UP1306, the comparator, and placebo without a significant association between the products. There was a significant difference between the changes of uCTX-II for UP1306 and placebo after 12 weeks. Early intervention with UP1306 aimed at reducing bone and cartilage degradation through reported inhibition of catabolic proinflammatory pathways may help to prevent joint cartilage damage. This study is registered with Clinical Trial ID ISRCTN15418623.

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Two-Year Results of the PHANTOM High Flex Trial: A Single-Arm Study on the Atlas Unicompartmental Knee System Load Absorber in Patients With Medial Compartment Osteoarthritis of the Knee

Clinical Medicine Insights Arthritis and Musculoskeletal Disorders ◽

10.1177/1179544119877170 ◽

2019 ◽

Vol 12 ◽

pp. 117954411987717

Author(s):

Konrad Slynarski ◽

Jacek Walawski ◽

Robert Smigielski ◽

Willem van der Merwe

Keyword(s):

Knee Osteoarthritis ◽

Invasive Surgery ◽

Young Patients ◽

Osteoarthritis Of The Knee ◽

Normal Range ◽

Medial Knee ◽

Medial Compartment Osteoarthritis ◽

Knee Oa ◽

And Function ◽

Post Implantation

The Atlas Knee System was designed to fill the gap between no longer effective conservative treatments and more invasive surgery for young patients with medial knee osteoarthritis (OA). This article reports on the 2-year results of a single-arm study of 26 subjects who previously reported favorable clinical outcomes 1 year post implantation. Western Ontario and McMaster Universities Osteoarthritis Index pain and function scores improved by a clinically meaningful amount relative to baseline, and subjects had a return to normal range of motion. This study confirmed that the benefit of a joint unloading device in the management of young patients with medial knee OA is maintained over 2 years. This trial was registered with ClinicalTrials.gov (NCT02711254).

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Intraarticular Injection of a Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal) to Provide Symptomatic Relief of Osteoarthritis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Trial

Cartilage ◽

10.1177/1947603517703732 ◽

2017 ◽

Vol 9 (3) ◽

pp. 276-283 ◽

Cited By ~ 19

Author(s):

Laszlo Hangody ◽

Robert Szody ◽

Piotr Lukasik ◽

Wojciech Zgadzaj ◽

Endre Lénárt ◽

...

Keyword(s):

Clinical Trial ◽

Knee Osteoarthritis ◽

Sodium Hyaluronate ◽

Intraarticular Injection ◽

Controlled Clinical Trial ◽

Osteoarthritis Of The Knee ◽

Womac Pain ◽

Double Blind ◽

Triamcinolone Hexacetonide ◽

And Function

Objective: To evaluate the efficacy and safety of an intraarticular injection of Cingal (Anika Therapeutics, Inc., Bedford, MA) compared with Monovisc (Anika Therapeutics, Inc., Bedford, MA) or saline for the treatment of knee osteoarthritis. Design: This multicenter, double-blind, saline-controlled clinical trial randomized subjects with knee osteoarthritis (Kellgren-Lawrence grades I-III) to a single injection of Cingal (4 mL, 88 mg hyaluronic acid [HA] plus 18 mg triamcinolone hexacetonide [TH]), Monovisc (4 mL, 88 mg HA), or saline (4 mL, 0.9%). The primary efficacy outcome was change in WOMAC (Western Ontario and McMaster Universities Arthritis Index) Pain Score through 12 weeks with Cingal versus saline. Secondary outcomes included Patient and Evaluator Global Assessments, OMERACT-OARSI Responder index, and WOMAC Total, Stiffness, and Physical Function scores through 26 weeks. Results: A total of 368 patients were treated (Cingal, n = 149; Monovisc, n = 150; saline, n = 69). Cingal improvement from baseline was significantly greater than saline through 12 weeks ( P = 0.0099) and 26 weeks ( P = 0.0072). WOMAC Pain was reduced by 70% at 12 weeks and by 72% at 26 weeks with Cingal. Significant improvements were found in most secondary endpoints for pain and function at most time points through 26 weeks. At 1 and 3 weeks, Cingal was significantly better than Monovisc for most endpoints; Cingal and Monovisc were similar from 6 weeks through 26 weeks. A low incidence of related adverse events was reported. Conclusions: Cingal provides immediate and long-term relief of osteoarthritis-related pain, stiffness, and function, significant through 26 weeks compared to saline. Cingal had similar immediate advantages compared with HA alone, while showing benefit comparable to HA at 6 weeks and beyond.

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A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF ABHA GUGGULU AND YOGARAJA GUGGULU IN JANU SANDHIGATA VATA

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj0409092021 ◽

2021 ◽

Vol 9 (9) ◽

pp. 1943-1950

Author(s):

Archana B.H. Jadav ◽

Susheel Shetty

Keyword(s):

Clinical Trial ◽

Statistical Difference ◽

Structure And Function ◽

The Body ◽

Osteoarthritis Of The Knee ◽

Basic Character ◽

Significant Difference ◽

Comparative Clinical Study ◽

And Function ◽

Single Blind

Mobility is the basic character of life that depends on the structural as well as the functional character of the body. As age advances, while proper nutrition is not available, the body loses its qualitative capacity for structure and function. Janu Sandhigata Vata has been explained classically by Acharyas and its lakshanas are Vata Poorna- dhrithi Sparsha, Sandhi Shotha, Sandhi Shoola and the presence of Vedana during Prasarana and Aakunchana. The lakshanas of Janu Sandhigata Vata is found to be congruent with Osteoarthritis of the Knee. Research statis- tics have shown that in India, 22% of the population shows Osteoarthritis and females slightly dominate in the incidence. Abha Guggulu and Yogaraja Guggulu are two formulations that contain the drugs of Vatahara, Shothahara, Vedanasthapaka property which will help in the management of Janu Sandhigata Vata. Methods: It was a single-blind randomized comparative clinical trial. The study was conducted on 40 subjects for 30 days. Observations were analyzed and findings were evaluated by using statistical methods. Results: The severity of symptoms markedly reduced in both the groups which is statistically significant and on comparing the effect be- tween Abha Guggulu and Yogaraja Guggulu, there was no statistical difference obtained. Conclusion: The result suggests that both Abha Guggulu and Yogaraja Guggulu had a significant effect on Janu Sandhigata Vata There was no significant difference in the effect of Abha Guggulu and Yogaraja Guggulu. Keywords: Janu Sandhigata Vata, Abha Guggulu, Yogaraja Guggulu

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PENGARUH GRASTON TECHNIQUE DAN CLOSED KINETIC CHAIN EXERCISE PADA OSTEOARTHRITIS KNEE DEXTRA

Jurnal Fisioterapi dan Rehabilitasi ◽

10.33660/jfrwhs.v4i1.103 ◽

2020 ◽

Vol 4 (1) ◽

pp. 64-71

Author(s):

Kuswardani . ◽

Fitratun Najizah ◽

Nurma Oktaviani

Keyword(s):

Knee Osteoarthritis ◽

Osteoarthritis Of The Knee ◽

Functional Abilities ◽

Kinetic Chain ◽

Physiotherapy Treatment ◽

Graston Technique ◽

Osteoarthritis Knee ◽

Closed Kinetic Chain ◽

Pre Treatment ◽

And Function

Background : The prevalence of osteoarthritis in Indonesia increases with age. The highest prevalence is at age <75 years. The incidence of osteoarthritis in Indonesia from 1990 to 2010 has increased. Per 100,000 men and women reach their peak at the 80 years old. Women reached a peak at 1,327.4 compared to men who were only 907.7. Osteoarthritis of the knee has problems such as pain, decreased ROM, edema, and decreased muscle strength, to overcome the problems in the case of knee osteoarthritis can be given physiotherapy treatment such as Graston Technique and Closed Kinetic Chain Exercise. Objective : The purpose of this study was to determine the effect of graston technique and closed kinetic chain exercise on knee dextra osteoarthritis to overcome body and function. Results : After being given physiotherapy management with a combination of graston technique and closed kinetic chain exercise in patients with knee osteoarthritis, there was a decrease in pain so that the increase in functional ability is known from the reduction of the diagram from the results of filling the WOMAC index form pre treatment with the score being post treatment in six meetings. Conclusion : The combination of graston technique and closed kinetic chain exercise has effect on reducing pain so that it can improve the functional abilities of patients with knee osteoarthritis.

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