scholarly journals MODIFICATION OF THE PFEFFER PANCREONECROSIS MODEL FOR ASSESSING PANCREATIC SECRETION IN THE ACUTE PERIOD OF DISEASE

2021 ◽  
pp. 42-47
Author(s):  
A.V. Borodach ◽  
◽  
N.I. Zakharov ◽  
Keyword(s):  
Experimental Study ◽  
Acute Pancreatitis ◽  
Pancreatic Secretion ◽  
Wistar Rats ◽  
Amylase Level ◽  
Exocrine Pancreatic Secretion ◽  
Acute Period ◽  
Closed Duodenal Loop

A preliminary experimental study: Measurement of exocrine pancreatic secretion was performed on Wistar rats after an induction of acute pancreatitis by ‘closed duodenal loop’ (CDL) method (total number of animals = 39). After 24 hrs duration of AP the CDL content was evacuated by syringe and tested for amylase level (IU/ml). A near normal output remained in most animals (1987,35 ± 558,26, n = 12); moderately decreased output was 264,67 ± 162,74 (n = 9), and cessation of the output in n = 3 (0,6 ± 0,3) (q < 0,01 for each group). So, in our series the exocrine pancreatic output was found diverging largely with a normal secretion prevailing. Further study is warranted for some conclusive results to obtain.

Intravenous mixed amino acids and fats do not stimulate exocrine pancreatic secretion

1984 ◽  
Vol 246 (3) ◽  
pp. G274-G280 ◽  
Author(s):  
B. E. Stabile ◽  
M. Borzatta ◽  
R. S. Stubbs ◽  
H. T. Debas
Keyword(s):  
Amino Acids ◽  
Acute Pancreatitis ◽  
Amino Acid ◽  
Pancreatic Secretion ◽  
Exocrine Pancreas ◽  
Amino Acid Mixture ◽  
Acid Mixture ◽  
Exocrine Pancreatic Secretion ◽  
Fat Emulsion ◽  
Graded Responses

We compared the responses of the canine exocrine pancreas to intraduodenal versus intravenous administration of mixed amino acids, fat emulsion, and glucose. Graded doses of amino acid mixture and of fat emulsion gave graded responses in volume, protein, and bicarbonate when administered intraduodenally. In contrast, the same doses of the amino acid mixture and fat emulsion administered by central intravenous infusion caused no significant pancreatic secretion of volume, protein, or bicarbonate. Graded doses of glucose caused no statistically significant pancreatic secretion whether they were given intraduodenally or intravenously. We conclude, contrary to a previously published observation, that amino acids and fats given parenterally do not stimulate pancreatic secretion. As a corollary, it is reasonable to assume that the pancreas is not stimulated during total parenteral nutrition with acute pancreatitis or a pancreatic fistula.

scholarly journals Disorder of natural killer cell functional activity in experimental stroke of different severity

2018 ◽  
pp. 124-127
Author(s):  
А.Е. Кульчиков
Keyword(s):  
Risk Factors ◽  
Experimental Study ◽  
Natural Killer Cell ◽  
Nk Cells ◽  
Natural Killer ◽  
Functional Activity ◽  
Wistar Rats ◽  
Killer Cell ◽  
Experimental Stroke ◽  
Acute Period

Актуальность. Изучение факторов риска развития инфекционно-воспалительных осложнений и путей их снижения при инсульте является актуальной неврологической проблемой. Цель: оценка функциональной активности клеток естественных киллеров в остром периоде экспериментального инсульта различной степени тяжести. Методы. В проведенном экспериментальном исследовании на животных (крысы линии Вистар, массой 200-220 г, n = 50) изучали функциональная активность естественных киллеров селезенки, при моделировании монополушарного левостороннего экспериментального инсульта (ЭИ) различной степени тяжести. Результаты. Показано, что у животных на 7-й день инсульта отмечается статистически значимое снижение функциональной активности естественных киллеров селезенки: ЭИ легкой степени - 20 (19; 23)%, р = 0,001, ЭИ средней степени - 19 (17; 21)%, р < 0,001, ЭИ тяжелой степени - 18 (16; 22)%, р < 0,001. Нарушения функциональной активности естественных киллеров более выражены на модели ЭИ средней и тяжёлой степени тяжести. Заключение. Показано, что при ЭИ наблюдается снижение функциональной активности естественных киллеров селезёнки, которое нарастает при увеличении степени тяжести инсульта. Background. Studying risk factors for development of infectious and inflammatory complications and ways to reduce them in stroke is a modern challenge to neurology. Aim: Evaluating the functional activity of natural killer (NK) cells in the acute period of experimental stroke (ES) of different severity. Methods. In this experimental study, the functional activity of spleen NK cells was studied in Wistar rats weighing 200-220 g (n = 50) with ES of different severity. Results. On the 7th day of stroke. the functional activity of spleen NK was significantly decreased: in mild ES, 20 (19; 23)%, р = 0.001, in moderate ES, 19 (17; 21)%, р <0.001, and in severe ES, (16; 22)%, р < 0.001. Disorders of the NK functional activity were more pronounced in moderate and severe ES. Conclusion. ES was associated with impaired functional activity of NK cells, which progressed with increasing grade of ES severity.

Modulatory action of Moringa oleifera Lam. on L-arginine induced acute pancreatitis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Tosan Peter Omayone ◽  
Omamuyovwi Meashack Ijomone ◽  
Solomon Babatunde Oloyede ◽  
Salihaat Toyin Okunola ◽  
Zainab Oluwabukola Aigoro ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Wistar Rats ◽  
Moringa Oleifera ◽  
Feed Consumption ◽  
Amylase Level ◽  
High Morbidity ◽  
Sh Group ◽  
Male Wistar Rats ◽  
Inflammatory Action ◽  
Moringa Oleifera Lam

Abstract Objectives Acute pancreatitis (AP) is an inflammatory disease of the pancreas with high morbidity and mortality. This study investigates the effect of Moring oleifera (MO) on L-arginine-induced AP in Wistar rats. Methods Male Wistar rats were randomly divided into seven groups. Control, AP, Magnesium groups, all fed with standard rat diet, MO leaf groups (5% MLF and 15% MLF), and MO seed groups (5% MSD and 15% MSD) were fed with five or 15% MO leaf or seed supplemented diet for four weeks prior to induction of AP. AP was induced by administration of double doses of L-arginine (320 mg/100 g i.p.) at 1 h interval. All animals were sacrificed 72 h thereafter. Results Weekly mean feed consumption and body weight were significantly higher in MO groups compared to the control. Amylase level, MDA, MPO, and NO were significantly higher in the AP group than in the control but decreased in Mg and MO groups. While CAT, SOD, GSH, and SH-group were significantly depleted in AP groups, which was attenuated in MO groups. Rats in AP groups showed severe inflammation, necrosis, and edema. These effects were significantly improved in MO groups resulting in lower histological scores compared to the AP group. Conclusions Pretreatment with MO could attenuate AP via its antioxidant and anti-inflammatory action.

The effect of stress conditions on exocrine pancreatic secretion in growing pigs

1999 ◽  
Vol 82 (4) ◽  
pp. 150-162 ◽  
Author(s):  
J. A. M. Botermans ◽  
J. Svendsen ◽  
B. R. Westrom ◽  
S. G. Pierzynowski
Keyword(s):  
Pancreatic Secretion ◽  
Growing Pigs ◽  
Stress Conditions ◽  
Exocrine Pancreatic Secretion

Inhibition of exocrine pancreatic secretion in dog by peptide YY is mediated by PYY-preferring Y2 receptors

1992 ◽  
Vol 40 (2) ◽  
pp. 162
Author(s):  
D Grandt ◽  
S Teyssen ◽  
M Schimiczek ◽  
E Niebergall ◽  
H Goebell ◽  
...  
Keyword(s):  
Pancreatic Secretion ◽  
Peptide Yy ◽  
Exocrine Pancreatic Secretion

Mnk1 is a novel acinar cell-specific kinase required for exocrine pancreatic secretion and response to pancreatitis in mice

Gut ◽  
2014 ◽  
Vol 64 (6) ◽  
pp. 937-947 ◽  
Author(s):  
Jaroslaw Cendrowski ◽  
Víctor J Sánchez-Arévalo Lobo ◽  
Matthias Sendler ◽  
Antonio Salas ◽  
Jens-Peter Kühn ◽  
...  
Keyword(s):  
Acinar Cell ◽  
Pancreatic Secretion ◽  
Exocrine Pancreatic Secretion
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