Cluster Analysis Evaluating PM2.5, Occupation Risk and Mode of Transportation as Surrogates for Air-pollution and the Impact on Lung Cancer Diagnosis and 1-Year Mortality

Introduction: The relationship between cancer and thromboembolic events has been known for a long time. Lung and venous thromboembolism are frequent complications of lung cancer and its treatment, being a great cause of morbidity and mortality. We pretend to establish the relationship between lung and venous thromboembolism and lung cancer, describe patient characteristics and analyze the impact in the survival and prognosis.Material and Methods: It was a retrospective study. All research subjects were selected from lung cancer patients with a newly diagnosed lung and venous thromboembolism event admitted to Hospital S. João, between January 2008 and December 2013 and were followed until December 2014. Statistical analysis was performed with SPSS.Results: From the search, we obtained 113 patients. The majority was male, smokers or ex-smokers, and adenocarcinoma was the most frequent histologic type, being diagnosed mostly in advanced stages. We noticed that the median time between lung cancer diagnosis and lung venous thromboembolism was 2.9 months. In 24 patients (21.4%), the lung cancer diagnosis occurred after the lung and venous thromboembolism event and in 86 patients (76.8%), it occurred before the event. After a median follow up of 1.4 months, 107 (94.7%) patients died, 1 (0.9%) was lost to follow-up and 5 (4.4%) were still alive. The median survival rate was 1.5 months.Discussion: The diagnosis of lung and venous thromboembolism in patients with lung cancer is associated with bad prognosis. It occurs most frequently in patients with advanced disease, in the first months after lung cancer diagnosis and after beginning chemotherapy.Conclusion: Disease progression is an independent predictor with negative impact in overall survival.

Download Full-text

Collateral effects of the coronavirus disease 2019 pandemic on lung cancer diagnosis in Korea

BMC Cancer ◽

10.1186/s12885-020-07544-3 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Ji Young Park ◽

Ye Jin Lee ◽

Taehee Kim ◽

Chang Youl Lee ◽

Hwan Il Kim ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Rapid Progression ◽

Lung Cancers ◽

The Past ◽

Lung Cancer Diagnosis ◽

Number Of Patients ◽

Wide Range ◽

Collateral Effects ◽

The Impact

Abstract Background The COVID-19 pandemic is predicted to significantly affect patients with lung cancer, owing to its rapid progression and high mortality. Studies on lung cancer diagnosis and treatment during an epidemic are lacking. We analyzed the impact of COVID-19 on lung cancer diagnosis in Korea, where lung cancer incidence continues to rise. Methods The number of newly diagnosed lung cancer cases in three university-affiliated hospitals during the pandemic and their clinical features were compared with lung cancer cases diagnosed during the same period in the past 3 years. The effectiveness of measures taken by the study hospitals to prevent nosocomial transmission was reviewed. Results A total of 612 patients were diagnosed with lung cancer from February through June, 2017–2020. During the pandemic, the number of patients who sought consultation at the division of pulmonology of study hospitals dropped by 16% from the previous year. Responding to the pandemic, the involved hospitals created physically isolated triage areas for patients with acute respiratory infection symptoms. Wide-range screening and preventive measures were implemented, thus minimizing the delay in lung cancer diagnosis. No patient acquired COVID-19 due to hospital exposure. The proportion of patients with stage III–IV non-small-cell lung cancer (NSCLC) significantly increased (2020: 74.7% vs. 2017: 57.9%, 2018: 66.7%, 2019: 62.7%, p = 0.011). The number of lung cancers diagnosed during this period and the previous year remained the same. Conclusions The proportion of patients with advanced NSCLC increased during the COVID-19 pandemic.

Download Full-text

The impact of the COVID-19 pandemic on lung cancer diagnosis and stage at Plymouth NHS Trust

Lung Cancer ◽

10.1016/s0169-5002(21)00239-7 ◽

2021 ◽

Vol 156 ◽

pp. S17

Author(s):

Helen McDill ◽

Maged Hassan ◽

Lindsey Taylor ◽

John Corcoran ◽

Cyrus Daneshvar

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Lung Cancer Diagnosis ◽

The Impact

Download Full-text

P2.01-76 The Impact of Concordance with a Lung Cancer Diagnosis Pathway Guideline on Treatment Access in Patients with Stage IV Lung Cancer

Journal of Thoracic Oncology ◽

10.1016/j.jtho.2018.08.1130 ◽

2018 ◽

Vol 13 (10) ◽

pp. S694

Author(s):

A. Pattison ◽

L. Jeagal ◽

J. Yeung ◽

A. Pierre ◽

L. Donahoe ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Stage Iv ◽

Treatment Access ◽

Lung Cancer Diagnosis ◽

Stage Iv Lung Cancer ◽

The Impact

Download Full-text

P112 The impact of Covid-19 pandemic on lung cancer diagnosis and treatment at St George’s Hospital

10.1136/thorax-2021-btsabstracts.221 ◽

2021 ◽

Author(s):

D Jajbhay ◽

J Arberry ◽

J Gates ◽

J Panguiton ◽

E Yarham ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Diagnosis And Treatment ◽

Lung Cancer Diagnosis ◽

The Impact

Download Full-text

Impact of smoke-free ordinance strength on smoking prevalence and lung cancer incidence.

Journal of Clinical Oncology ◽

10.1200/jco.2019.37.15_suppl.6578 ◽

2019 ◽

Vol 37 (15_suppl) ◽

pp. 6578-6578

Author(s):

Ryan Nguyen ◽

Laura Vater ◽

Lava R Timsina ◽

Greg Andrew Durm ◽

Katelin Rupp ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Cancer Incidence ◽

Smoking Prevalence ◽

Income Poverty ◽

Tobacco Prevention ◽

County Level ◽

Lung Cancer Incidence ◽

Lung Cancer Diagnosis ◽

The Impact

6578 Background: Smoke-free ordinances (SFO) have been shown to decrease the prevalence of cardiovascular and pulmonary disease, but there is limited data on the impact of such policies on lung cancer incidence. We investigated the relationship between strength of county-level SFO with smoking prevalence and lung cancer incidence in Indiana. Methods: Following IRB approval, we queried the Indiana State Cancer Registry and Indiana Tobacco Prevention and Cessation Commission’s policy database between 1995 and 2016. County-level characteristics included population, income, poverty, education, race/ethnicity, sex, and rurality. Lung cancer diagnosis and stage were also collected. Using generalized estimating equations (GEE) with robust standard errors and accounting for the clustering effect at county level, we performed multivariable analyses of smoking prevalence and age-adjusted lung cancer rates with respect to the strength of smoke-free ordinances at the county level over time. Results: Indiana consists of 92 counties, 24 of which had SFO by 2011. In 2012, Indiana enacted a law mandating at least a moderate state-wide SFO. From 1995 to 2016, 110,935 Indiana residents were diagnosed with lung cancer. Indiana also had an average age-adjusted yearly lung cancer incidence of 76.8 per 100,000 population and average yearly smoking prevalence of 25% during this time. Smoking prevalence was 1.2% (95% CI [-1.88, -0.52]) lower in counties with comprehensive or moderate SFO compared with those with weak or no SFO. Counties that had comprehensive or moderate SFO had an 8.36 (95% CI [-11.45, -5.27]) decrease in new lung cancer diagnosis per 100,000 population per year compared with counties that had weak or no SFO. Conclusions: Stronger municipal smoke-free air ordinances are associated with decreased smoking prevalence and fewer new lung cancer cases. Strengthening smoke-free ordinances is paramount to decreasing lung cancer incidence.

Download Full-text

The impact of concordance with a lung cancer diagnosis pathway guideline on treatment access in patients with stage IV lung cancer

Journal of Thoracic Disease ◽

10.21037/jtd-20-157 ◽

2020 ◽

Vol 12 (8) ◽

pp. 4327-4337

Author(s):

Andrew Pattison ◽

Luke Jeagal ◽

Kazuhiro Yasufuku ◽

Andrew Pierre ◽

Laura Donahoe ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Stage Iv ◽

Treatment Access ◽

Lung Cancer Diagnosis ◽

Stage Iv Lung Cancer ◽

The Impact

Download Full-text

Collateral effects of the coronavirus disease 2019 pandemic on lung cancer diagnosis in Korea

10.21203/rs.3.rs-81855/v1 ◽

2020 ◽

Author(s):

Ji Young Park ◽

Ye Jin Lee ◽

Taehee Kim ◽

Chang Youl Lee ◽

Hwan Il Kim ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Diagnosis ◽

Rapid Progression ◽

Lung Cancers ◽

The Past ◽

Lung Cancer Diagnosis ◽

Number Of Patients ◽

Wide Range ◽

Collateral Effects ◽

The Impact

Abstract Background The COVID-19 pandemic is predicted to significantly affect patients with lung cancer, owing to its rapid progression and high mortality. Studies on lung cancer diagnosis and treatment during an epidemic are lacking. We analyzed the impact of COVID-19 on lung cancer diagnosis in Korea, where lung cancer incidence continues to rise.Methods The number of newly diagnosed lung cancer cases in three university-affiliated hospitals during the pandemic and their clinical features were compared with lung cancer cases diagnosed during the same period in the past three years. The effectiveness of measures taken by the study hospitals to prevent nosocomial transmission was reviewed.Results Between February and June during 2017–2020. 612 patients with lung cancer were diagnosed. During the pandemic, the number of patients who sought consultation at the division of pulmonology of study hospitals dropped by 16% from the previous year. Responding to the pandemic, the involved hospitals created physically isolated triage areas for patients with acute respiratory infection symptoms. Wide-range screening and preventive measures were implemented, thus minimizing delay in lung cancer diagnosis. No patients acquired COVID-19 due to hospital exposure. The proportion of patients with stage III–IV non-small-cell lung cancer (NSCLC) significantly increased (2020: 74.7% vs. 2017: 57.9%, 2018: 66.7%, 2019: 62.7%, p=0.011). The number of lung cancers diagnosed during this period and the previous year remained the same.Conclusion The proportion of patients with advanced NSCLC increased during the COVID-19 pandemic.

Download Full-text