scholarly journals Evaluation of the Receptor Activator of Nuclear Factor Kappa B Ligand (RANKL) Expression in Osteosarcoma and Its Association with the Clinicopathological Data

2021 ◽  
Vol 22 (3) ◽  
pp. 741-747
Author(s):  
Hui Chua ◽  
Sharifah Emilia Tuan Sharif ◽  
Wan Faisham Nu’man Wan Ismail ◽  
Muhamad Syahrul Fitri Zawawi ◽  
Sarimah Abdullah
Keyword(s):  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Rankl Expression ◽  
Nuclear Factor Kappa ◽  
Receptor Activator

scholarly journals Triiodothyronine (T3) does not induce Rankl expression in rat Ros 17/2.8 cells

2008 ◽  
Vol 52 (1) ◽  
pp. 109-113 ◽  
Author(s):  
Patrícia P. Saraiva ◽  
Silvania S. Teixeira ◽  
Célia Regina Nogueira ◽  
Carlos Roberto Padovani
Keyword(s):  
Messenger Rna ◽  
Nuclear Factor Kappa B ◽  
Osteoclast Differentiation ◽  
Hormone Treatment ◽  
Nuclear Factor ◽  
Rankl Expression ◽  
Loss Mechanism ◽  
Nuclear Factor Kappa ◽  
Rankl Mrna ◽  
Receptor Activator

Osteoclastogenesis may be regulated via activation of the RANK/RANKL (receptor activator of nuclear factor-kappa B/ receptor activator of nuclear factor-kappa B ligand) system, which is mediated by osteoblasts. However, the bone loss mechanism induced by T3 (triiodothyronine) is still controversial. In this study, osteoblastic lineage rat cells (ROS 17/2.8) were treated with T3 (10-8 M, 10-9 M, and 10-10 M), and RANKL mRNA (messenger RNA) expression was measured by semiquantitative RT-PCR. Our results show that T3 concentrations used did not significantly enhance RANKL expression compared to controls without hormone treatment. This data suggests that other mechanisms, unrelated to the RANK/RANKL system, might be to activate osteoclast differentiation in these cells.

Osteoprotegerin (OPG) levels, total soluble receptor activator of nuclear factor-Kappa B ligand (total sRANKL) , and RANKL/OPG ratio in patients with rheumatoid arteritis

2017 ◽  
Vol 2 (1) ◽  
pp. 23-29
Author(s):  
Sousan Kolahi ◽  
Amir Ghorbanihaghjo ◽  
Nadereh Rashtchizadeh ◽  
Alireza Khabbazi ◽  
Mehrzad Hajialilo ◽  
...  
Keyword(s):  
Nuclear Factor Kappa B ◽  
Nuclear Factor ◽  
Soluble Receptor ◽  
Nuclear Factor Kappa ◽  
Receptor Activator
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