Management of Choroid Plexus Papillomas

Introduction: Choroid plexus papillomas are rare neuroepithelial tumors found primarily in children. It represents less than 1% of all central nervous system tumors. Materials and methods: A retrospective study including 14 patients with choroid plexus papilloma tumors were performed at the Neurosurgery Department in Ait IDDIR Health Hospital Establishment between January 2010 and December 2017. In each case, diagnosis was made clinically and confirmed radiologically and histo-pathologically. All patients were operated. Results and discussion: The mean age was 26 years (ranged 3 months –48 years) .In our department, we grouped together 14 cases of choroid plexus papilloma tumors. For mortality we had one case who died during surgery, survival rate for 04 years is 100% .We had not recurrence during the study period.All patients had intracranial hypertension (HIC) without neurological deficit and benefited from brain CT, MRI and an Angiography. The location of the tumor was: Lateral ventricle, Fourth ventricle, Third ventricle. All patients underwent surgical excision with or without ventriculo-peritoneal shunt. Conclusion: Choroid plexus papillomas are rare neuroepithelial tumors, typically considered benign lesions, derived from the choroid plexus and appear like cauliflower.

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Choroid plexus papilloma of the third ventricle

Neurosurgery ◽

10.1097/00006123-198302000-00016 ◽

1983 ◽

Vol 12 (2) ◽

pp. 217???20 ◽

Cited By ~ 3

Author(s):

W C Gradin ◽

C Taylon ◽

A H Fruin

Keyword(s):

Choroid Plexus ◽

Third Ventricle ◽

Choroid Plexus Papilloma ◽

The Third ◽

Plexus Papilloma

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Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism

Neuro-Oncology ◽

10.1093/neuonc/noz167.040 ◽

2019 ◽

Vol 21 (Supplement_4) ◽

pp. iv9-iv10

Author(s):

Ashirwad Merve ◽

Xinyu Zhang ◽

Nicola Pomella ◽

Serena Acquati ◽

Joerg Hoeck ◽

...

Keyword(s):

T Cell ◽

Mouse Model ◽

Choroid Plexus ◽

Tumour Size ◽

Choroid Plexus Papilloma ◽

Experimental Models ◽

Chemotherapeutic Agents ◽

Human Choroid Plexus ◽

Choroid Plexus Papillomas ◽

Plexus Papilloma

Abstract Choroid plexus tumours (CPT) account for up to 20% of brain tumours in children under 2 years of age. Histologically CPTs are classified into three categories - Choroid Plexus Papilloma (CPP), Atypical Choroid Plexus Papilloma (ACPP) and Choroid Plexus Carcinoma (CPC). Recent literature demonstrates that CPP and ACPP are molecularly distinct from CPC. Initial management for CPT include surgery followed by adjuvant therapy in selected patients. Currently there are no disease-specific chemotherapeutic agents available, possibly because of their rarity and paucity of faithful pre-clinical experimental models. In this study we show that c-Myc overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus papillomas in a mouse model. We demonstrate that c-MYC is expressed in a substantial proportion of human choroid plexus tumours and that this subgroup of tumours is characterised by an inflammatory transcriptome and significant inflammatory infiltrates. We observed that triple transgenic compound mutant mouse model with c-Myc overexpression in an immune-suppressed background led to a decreased incidence of CPP and reduced tumour bulk. A reduced tumour size was also observed when c-Myc overexpressing mice were treated with anti-CD3 antibodies. Our data raise the possibility that benign choroid plexus tumours expressing c-MYC could be amenable to medical therapy with anti-inflammatory drugs.

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Lateral Ventricle Choroid Plexus Papilloma Extending into the Third Ventricle

Pediatric Neurosurgery ◽

10.1159/000083747 ◽

2004 ◽

Vol 40 (6) ◽

pp. 314-316 ◽

Cited By ~ 9

Author(s):

Federico Di Rocco ◽

Massimo Caldarelli ◽

Giovanni Sabatino ◽

Gianpiero Tamburrini ◽

Concezio Di Rocco

Keyword(s):

Choroid Plexus ◽

Lateral Ventricle ◽

Third Ventricle ◽

Choroid Plexus Papilloma ◽

The Third ◽

Plexus Papilloma

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Third ventricular choroid plexus papilloma with psychosis

Journal of Neurosurgery ◽

10.3171/jns.1997.87.1.0103 ◽

1997 ◽

Vol 87 (1) ◽

pp. 103-105 ◽

Cited By ~ 10

Author(s):

Benjamin S. Carson ◽

Jon D. Weingart ◽

Michael Guarnieri ◽

Paul G. Fisher

Keyword(s):

Choroid Plexus ◽

Behavioral Problems ◽

Third Ventricle ◽

Choroid Plexus Papilloma ◽

Pathological Examination ◽

Psychiatric Evaluation ◽

Content Type ◽

Resected Tumor ◽

History Of ◽

Plexus Papilloma

✓ This 9-year-old boy with a history of behavioral problems and worsening psychosis responded initially to treatment with haloperidol. However, a magnetic resonance image obtained as part of his psychiatric evaluation revealed an anterior third ventricle tumor and mild-to-moderate hydrocephalus. The resected tumor was found on pathological examination to be a choroid plexus papilloma. The patient had an uneventful postoperative course and remained free of psychosis or mood disorder at 1-year follow-up examination.

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Intrinsic brainstem choroid plexus papilloma

Journal of Neurosurgery ◽

10.3171/jns.2004.100.6.1076 ◽

2004 ◽

Vol 100 (6) ◽

pp. 1076-1078 ◽

Cited By ~ 23

Author(s):

Ashok Pillai ◽

Kariyattil Rajeev ◽

Sushil Chandi ◽

Muthukuttiparambil Unnikrishnan

Keyword(s):

Central Nervous System ◽

Choroid Plexus ◽

Choroid Plexus Papilloma ◽

Residual Tumor ◽

Brainstem Lesion ◽

Content Type ◽

The Central Nervous System ◽

Choroid Plexus Papillomas ◽

Fine Print ◽

Plexus Papilloma

✓ The authors report an intrinsic brainstem lesion that was diagnosed initially as a pontine cavernoma, which finally proved to be a choroid plexus papilloma. Choroid plexus papillomas are rare tumors of the central nervous system and are usually intraventricular in location. The occurrence of this tumor in an intraparenchymal location is extremely rare, and its occurrence within the brainstem is previously unreported. The authors also report a trial of chemotherapy with lomustine in the management of the residual tumor.

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