Study of Eosinophil Count in Nasal and Peripheral Blood Smear Compare with Serum IgE Level in Children with Allergic Rhinitis

Introduction: Allergic rhinitis is one of the most common respiratory diseases. Patient with allergic rhinitis may have elevated level of serum IgE and eosinophil than normal person. Nasal smear eosinophil count is a simple test as well as noninvasive, can be repeated and inexpensive method for diagnosis of allergic rhinitis. Objective: To assess the eosinophil count in nasal smear as an alternative diagnostic test for children with allergic rhinitis. Methods: This cross-sectional study was conducted at the Department of Laboratory medicine and Paediatrics, BSMMU, Dhaka from September 2019 to August 2020 in 120 children (Age up to 18 years both sex). Diagnosed patients of allergic rhinitis according to ARIA-WHO guideline with history and clinical feature who fulfilled the inclusion criteria were selected as study population. After taking informed written consent blood and nasal secretion of allergic patient were drawn for serum IgE and eosinophil count. Nasal smears for eosinophil were stained using Giemsa stain and observed eosinophil under light microscope. Peripheral blood eosinophil count was estimated by hematology auto-analyzer (SYSMEX-XN 2000) and rechecked manually. The serum total IgE level was performed based on sandwich principle of ELISA. Results: The serum IgE level, nasal smear eosinophil count and blood eosinophil count were found increased with severity of allergic rhinitis, which was statistically significant (p<0.001). Pearson’s correlation coefficient test revealed significant positive correlation between nasal smear eosinophil count with serum IgE (r= +.656, p<0.001) and blood absolute eosinophil count (r= +.415, p<0.001). Conclusion: Nasal smear eosinophil count was significantly raised alone with absolute eosinophil count and serum IgE level with the severity of allergic rhinitis in children.

Download Full-text

Does peripheral blood eosinophil count predict lung function improvement in adult asthmatic subjects?

Annals of Allergy Asthma & Immunology ◽

10.1016/j.anai.2021.05.024 ◽

2021 ◽

Author(s):

Juçara Noeli Silva ◽

Alcides Rocha ◽

Ivani Aparecida de Souza ◽

Rodrigo Athanazio ◽

Eduardo Vieira Ponte

Keyword(s):

Lung Function ◽

Peripheral Blood ◽

Eosinophil Count ◽

Blood Eosinophil ◽

Peripheral Blood Eosinophil ◽

Blood Eosinophil Count ◽

Adult Asthmatic

Download Full-text

Evaluation of the peripheral blood eosinophil count as a predictor for fractional exhaled nitric oxide or bronchodilator reversibility test outcome

Allergy and Asthma Proceedings ◽

10.2500/aap.2021.42.210016 ◽

2021 ◽

Vol 42 (3) ◽

pp. 228-234

Author(s):

Bo Zhao ◽

Haiming Zheng ◽

Xiaopan Li ◽

Rui Zheng

Keyword(s):

Nitric Oxide ◽

Roc Curve ◽

Peripheral Blood ◽

Eosinophil Count ◽

Blood Eosinophil ◽

Test Results ◽

Fractional Exhaled Nitric Oxide ◽

Peripheral Blood Eosinophil ◽

Blood Eosinophil Count ◽

Feno Level

Objective: This study aimed to explore the usefulness of the peripheral blood eosinophil count (PBEC) in assessing the level of fractional exhaled nitric oxide (FeNO) and predicting bronchodilation test results. Methods: We retrospectively analyzed the data of 384 outpatients who underwent FeNO measurement at our Department of Respiratory and Critical Care Medicine from March to June 2019. The FeNO level was compared among different PBECs to explore the association among them. Furthermore, the sensitivity and specificity of PBECs in predicting bronchodilation test results were assessed by using receiver operating characteristic (ROC) curve analysis. Results: There was a moderate correlation between PBECs and FeNO levels (r = 0.414; p < 0.05). In the subjects with PBECs ≥ 0.3 × 109/L, the median FeNO level was 39 ppb (interquartile range, 22.5‐65.5 ppb), significantly higher than in the subjects with PBECs < 0.3 × 109/L. The area under the ROC curve was 0.707 (p < 0.05). The maximum Youden index (0.348) was at PBECs = 0.205 × 109/L, which achieved sensitivity and specificity of 63% and 71.8%, respectively. Conclusion: PBECs ≥ 0.3 × 109/L can predict a positive bronchodilation test result and a high FeNO level, with a probability of 50% in the subjects with chronic cough and shortness of breath; in the absence of corresponding symptoms and a low PBEC, the predictive value was small. For hospitals not able to conduct FeNO measurements, for outpatients with poor economic conditions, and for patients with confirmed or suspected novel coronavirus disease 2019, the PBEC, in conjunction with a patient's clinical symptoms, can improve the diagnostic accuracy of allergic asthma and assessment of airway inflammation while reducing the risk of infection.

Download Full-text

Peripheral blood eosinophil count correlates with survival in lung cancer

Lung Cancer ◽

10.1016/s0169-5002(10)70123-9 ◽

2010 ◽

Vol 67 ◽

pp. S40-S41 ◽

Cited By ~ 1

Author(s):

A. Shelton ◽

R.H. Green ◽

P. Bradding ◽

C.M. Free

Keyword(s):

Lung Cancer ◽

Peripheral Blood ◽

Eosinophil Count ◽

Blood Eosinophil ◽

Peripheral Blood Eosinophil ◽

Blood Eosinophil Count

Download Full-text

The impact of high peripheral blood eosinophil count during treatment of infective COAD exacerbation on the length of hospital stay and the rate of readmission

Clinical Microbiology and Infectious Diseases ◽

10.15761/cmid.1000130 ◽

2018 ◽

Vol 3 (1) ◽

Author(s):

Ibrahim TM ◽

Abdullah Al-allawi ◽

Jaganaathan Srinivasan

Keyword(s):

Hospital Stay ◽

Peripheral Blood ◽

Eosinophil Count ◽

Length Of Hospital Stay ◽

Blood Eosinophil ◽

Peripheral Blood Eosinophil ◽

Blood Eosinophil Count ◽

The Impact

Download Full-text

Prognostic value of peripheral blood eosinophil count on first day of infancy in the incidence of neonatal hyperbilirubinemia

International Journal of Scientific Reports ◽

10.18203/issn.2454-2156.intjscirep20181845 ◽

2018 ◽

Vol 4 (5) ◽

pp. 99

Author(s):

Adel Ahadi ◽

Mehrdad Mirzarahimi ◽

Saeid Alaei ◽

Farzad Ahmadabadi

Keyword(s):

Gestational Age ◽

Significant Relationship ◽

Peripheral Blood ◽

Eosinophil Count ◽

Prognostic Value ◽

Serum Bilirubin ◽

Total Serum ◽

Blood Eosinophil ◽

Peripheral Blood Eosinophil ◽

Blood Eosinophil Count

Background: Neonatal jaundice is one of the most common problems in the neonatal period. Eosinophilia is common in preterm and term newborns, and it is considered when the absolute count of eosinophil is ≥500 cell/mm3. It is thought that there was some relationship between hyperbilirubinemia and increasing of blood eosinophil count in newborns hospitalized by jaundice. The aim of this study was to determine the prognostic value of peripheral blood eosinophil count on first day of infancy in the incidence of neonatal hyperbilirubinemia.Methods: 150 newborns with gestational ages of 35-40 weeks, born in Ardabil city hospital, were engaged in this study. After obtaining the parents' consent, getting patients biography and their physical examination, we got a blood sample from umbilical cord of newborns to measure differential count of white blood cells. The neonates were observed up to 28 day followed. Then, second blood test conducted for the purpose of measuring serum level of bilirubin. Data were analyzed by statistical methods in SPSS version 19. Results: Various group of age, sex, blood type and gestational age showed no significant difference in their eosinophil rate. Total serum bilirubin doesn't had a significant relationship with gestational age, sex, type of delivery and major or minor blood groups of neonates.Conclusions: Results showed that there was no significant relationship between the amount of eosinophil in newborn umbilical cord and total serum bilirubin. So, we could say that newborns eosinophil count isn’t a good criteria for predicating the appearance of neonate hyperbilirubinemia.

Download Full-text