scholarly journals Biochemical Studies on the Protective Effects of Picrorhiza kurroa in Experimentally Induced Hepatitis in Rats.

2000 ◽  
Vol 29 ◽  
pp. 9-17
Author(s):  
Rangasamy ANANDAN ◽  
Ravikumar DEEPA REKHA ◽  
Thiruvengadam DEVAKI ◽  
Mani SANTHOSH KUMAR
Keyword(s):  
Protective Effects ◽  
Picrorhiza Kurroa ◽  
Biochemical Studies ◽  
Experimentally Induced

scholarly journals Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NFκB, STAT3, and Nrf2 as Potential Targets

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 479
Author(s):  
Seong Hoon Kim ◽  
Hye-Won Yum ◽  
Seung Hyeon Kim ◽  
Wonki Kim ◽  
Su-Jung Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Parent Compound ◽  
Oxidative Stress Marker ◽  
Heme Oxygenase 1 ◽  
Trinitrobenzene Sulfonic Acid ◽  
Protective Effects ◽  
Taurine Chloramine ◽  
Proinflammatory Mediators ◽  
Experimentally Induced

Taurine chloramine (TauCl) is an endogenous anti-inflammatory substance which is derived from taurine, a semi-essential sulfur-containing β-amino acid found in some foods including meat, fish, eggs and milk. In general, TauCl as well as its parent compound taurine downregulates production of tissue-damaging proinflammatory mediators, such as chemokines and cytokines in many different types of cells. In the present study, we investigated the protective effects of TauCl on experimentally induced colon inflammation. Oral administration of TauCl protected against mouse colitis caused by 2,4,6-trinitrobenzene sulfonic acid (TNBS). TauCl administration attenuated apoptosis in the colonic mucosa of TNBS-treated mice. This was accompanied by reduced expression of an oxidative stress marker, 4-hydroxy-2-nonenal and proinflammatory molecules including tumor necrosis factor-α, interleukin-6 and cyclooxygenase-2 in mouse colon. TauCl also inhibited activation of NFκB and STAT3, two key transcription factors mediating proinflammatory signaling. Notably, the protective effect of TauCl on oxidative stress and inflammation in the colon of TNBS-treated mice was associated with elevated activation of Nrf2 and upregulation of its target genes encoding heme oxygenase-1, NAD(P)H:quinone oxidoreductase, glutamate cysteine ligase catalytic subunit, and glutathione S-transferase. Taken together, these results suggest that TauCl exerts the protective effect against colitis through upregulation of Nrf2-dependent cytoprotective gene expression while blocking the proinflammatory signaling mediated by NFκB and STAT3.

scholarly journals Chemical composition, antioxidant and macromolecule damage protective effects of Picrorhiza kurroa Royle ex Benth

2014 ◽  
Vol 94 ◽  
pp. 249-254 ◽  
Author(s):  
K. Krupashree ◽  
K. Hemanth Kumar ◽  
P. Rachitha ◽  
G.V. Jayashree ◽  
F. Khanum
Keyword(s):  
Chemical Composition ◽  
Protective Effects ◽  
Picrorhiza Kurroa

PROTECTIVE EFFECTS OF C5aR ANTAGONIST IN EXPERIMENTALLY INDUCED SEPSIS.

Shock ◽  
2001 ◽  
Vol 15 (Supplement) ◽  
pp. 89
Author(s):  
M. Huber-Lang ◽  
V. Sarma ◽  
K. T. Lu ◽  
E. Younkin ◽  
N. Riedemann ◽  
...  
Keyword(s):  
Protective Effects ◽  
Experimentally Induced

Effect of Physical Exercise on Endometriosis Experimentally Induced in Rats

2018 ◽  
Vol 26 (6) ◽  
pp. 785-793 ◽  
Author(s):  
Mary Lourdes Montenegro ◽  
Camila M. Bonocher ◽  
Juliana Meola ◽  
Rafael L. Portella ◽  
Alfredo Ribeiro-Silva ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Uterine Cavity ◽  
Nuclear Antigen ◽  
Protective Effects ◽  
Beneficial Effects ◽  
Female Wistar Rats ◽  
Inflammatory Processes ◽  
Matrix Metalloproteinases 9 ◽  
Intense Activity ◽  
Experimentally Induced

Objective: Endometriosis is characterized by the growth of endometrial tissue outside the uterine cavity. The prevalence of endometriosis among women experiencing pain, infertility, or both is as high as 35% to 50%. The most common symptoms of endometriosis are dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Evidence has suggested that endometriosis symptoms result from a local inflammatory peritoneal reaction caused by ectopic endometrial implants that undergo cyclic bleeding. On the other hand, regular physical exercise seems to have protective effects against diseases that involve inflammatory processes such as type 2 diabetes and colon and breast cancer. On this basis, it is possible that the practice of physical exercise may have beneficial effects on endometriosis. Therefore, the objective of this study was to evaluate the possible anti-inflammatory effect of physical exercise on endometriosis experimentally induced in rats. Study Design: Seventy female Wistar rats were divided into 7groups of 10 animals each. Animals performed light exercise (swimming once a week), moderate exercise (swimming 3 times a week), and intense exercise (swimming 5 times a week) before or after endometriosis induction. Results: At the end of the experimental protocol, a reduction in the size of endometriotic lesions was observed after physical exercise regardless of its frequency, with a greater reduction in the groups practicing moderate and intense activity; an increase in FAS levels and a decrease in matrix metalloproteinases 9 and proliferating cell nuclear antigen (PCNA)levels was also observed. The immunohistochemistry results did not lead to conclusive results. As expected, oxidative stress was reduced in all groups. These results show that the practice of physical exercise could be beneficial, at least in part, for the treatment of endometriosis.

Protective Effects ofTridax procumbensLinn. Leaves on Experimentally Induced Gastric Ulcers in Rats

2015 ◽  
Vol 21 (3) ◽  
pp. 308-320
Author(s):  
Susheela Jhariya ◽  
Gopal Rai ◽  
Awesh K. Yadav ◽  
Alok Pal Jain ◽  
Santram Lodhi
Keyword(s):  
Gastric Ulcers ◽  
Protective Effects ◽  
Experimentally Induced

scholarly journals Biochemical Studies on the Protective Effect of Betaine on Mitochondrial Function in Experimentally Induced Myocardial Infarction in Rats

2007 ◽  
Vol 53 (6) ◽  
pp. 671-681 ◽  
Author(s):  
Balaraman Ganesan ◽  
Rangasamy Rajesh ◽  
Rangasamy Anandan ◽  
Nanjappan Dhandapani
Keyword(s):  
Myocardial Infarction ◽  
Protective Effect ◽  
Mitochondrial Function ◽  
Biochemical Studies ◽  
Experimentally Induced
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