Most of the high school students have an aversion to the subject of chemistry. This fact is, probably, due to the complexity of the phenomena involved in chemical transformations and little interdisciplinarity and /or transdisciplinarity in relation to the daily life of students and with other subjects. Therefore, the teacher must find ways to assist the pedagogical teaching-learning process in chemistry. The development of modern and simple strategies, using experiments, games and other teaching resources, is recommended to streamline the process of learning chemistry. The aim of this work was to employ a game as a didactical resource to facilitate the teaching-learning process in chemistry. The game used was Sudoku, and the version employed was called Sudokímica. The material was applied in three high school classes of a public school in Natal-RN, Brazil. The didactical resource was successful in the sense of facilitating and integrating the scientific and daily life knowledge of the students. It can be concluded that the game, Sudokímica can be considered good alternative to supplementary material in the teaching-learning process in chemistry through for resolution of problems.