Designing a replacement heifer rearing strategy: Effects of growth profile on performance of Norwegian Red heifers and cows

Tetrahymena telomeres usually consist of ∼250 base pairs of T2G4 repeats, but they can grow to reach a new length set point of up to 900 base pairs when kept in log culture at 30°C. We have examined the growth profile of individual macronuclear telomeres and have found that the rate and extent of telomere growth are affected by the subtelomeric region. When the sequence of the rDNA subtelomeric region was altered, we observed a decrease in telomere growth regardless of whether the GC content was increased or decreased. In both cases, the ordered structure of the subtelomeric chromatin was disrupted, but the effect on the telomeric complex was relatively minor. Examination of the telomeres from non-rDNA chromosomes showed that each telomere exhibited a unique and characteristic growth profile. The subtelomeric regions from individual chromosome ends did not share common sequence elements, and they each had a different chromatin structure. Thus, telomere growth is likely to be regulated by the organization of the subtelomeric chromatin rather than by a specific DNA element. Our findings suggest that at each telomere the telomeric complex and subtelomeric chromatin cooperate to form a unique higher order chromatin structure that controls telomere length.

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The Rv1651c-encoded PE-PGRS30 protein expressed in Mycobacterium smegmatis exhibits polar localization and modulates its growth profile

FEMS Microbiology Letters ◽

10.1111/j.1574-6968.2011.02354.x ◽

2011 ◽

Vol 322 (2) ◽

pp. 194-199 ◽

Cited By ~ 13

Author(s):

Shweta Chatrath ◽

Vineet Kumar Gupta ◽

Aparna Dixit ◽

Lalit C. Garg

Keyword(s):

Mycobacterium Smegmatis ◽

Polar Localization ◽

Growth Profile

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Growth Outcome and Metabolic Profile of PWS Patients Treated With GH and Differences Between AGA and SGA Group

Journal of the Endocrine Society ◽

10.1210/jendso/bvab048.1381 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. A677-A678

Author(s):

Ju Young Yoon ◽

Chong Kun Cheon ◽

Seok Dong Yoo

Keyword(s):

Glucose Level ◽

Uniparental Disomy ◽

Metabolic Dysfunction ◽

Duration Of Treatment ◽

Gh Treatment ◽

Laboratory Findings ◽

Growth Impairment ◽

Growth Profile ◽

Metabolic Dysfunctions ◽

Mean Glucose

Abstract Objective: Prader-Willi syndrome (PWS) is a complex genetic disease associated with growth impairment, severe obesity and metabolic dysfunctions. High proportion of PWS patients are born small for gestational age (SGA), which also increase the risk of growth impairment and metabolic dysfunction. The aim of this study was to describe growth outcome and and metabolic profiles in GH treated PWS patients. We also investigated the differences in clinical outcomes between AGA and SGA group Methods: Data of 55 children and adults with genetically verified PWS aged more than 2 years old (32 male and 23 female, age 2-18.8 years) from single center were studied. Only patients who were treated with GH were included. The clinical characteristics and laboratory findings were reviewed retrospectively. Results: Among 55 subjects, 39 had 15q11-13 deletion and 16 had uniparental disomy (UPD). Twenty (36.3%) were born SGA. All patients received GH treatment, and 11 (20%) discontinued GH treatemnt. Mean age at GH treatment initiation was 2.5 (range 0.3-12.4) years, and mean duration of treatment was 6.3 (range 1.0-11.3) years. Current height-SDS (-0.36 vs -0.16) and BMI-SDS (1.44 vs 1.33) did not differ between AGA and SGA group. Two patients in SGA group, but none in AGA group had diabetes mellitus. Mean glucose level was also higher in SGA group (100.1 vs 114.4 mg/dL) Conclusions: Our report gives an overview of growth profile and metabolic dysfunctions recorded in GH treated PWS patients. Growth profile did not differ between AGA and SGA group. Glucose level was higher in SGA group, so more careful monitoring and prevention for DM will be required in SGA group.

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