Choroid plexus adenoma in a child: expanding the clinical and pathological spectrum

2018 ◽  
Vol 21 (4) ◽  
pp. 428-433 ◽  
Author(s):  
Nicole Prendergast ◽  
Jeffrey D. Goldstein ◽  
Alexandra D. Beier
Keyword(s):  
Differential Diagnosis ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Choroid Plexus Tumors ◽  
Plexus Papilloma

Primary choroid plexus tumors encompass a variety of tumors, with choroid plexus papilloma and carcinoma being the most common. Also in the differential diagnosis is the rare benign choroid plexus adenoma. As these tumors are infrequently described, the histological profile continues to evolve. The authors present a case with unusual characteristics that will broaden the pathological spectrum for choroid plexus adenomas.

scholarly journals Choroid Plexus Papilloma with Dandy Walker Variant: Co-existence or Association- A Case Report

2019 ◽  
Vol 46 (2) ◽  
pp. 61-65
Author(s):  
Mohammad Hossain ◽  
Nazmin Ahmed ◽  
Narendra Shalike ◽  
Md Rokibul Islam ◽  
Soumen Samadder ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Communicating Hydrocephalus ◽  
Intermediate Form ◽  
Genetic Syndromes ◽  
Who Grade ◽  
Choroid Plexus Tumors ◽  
Well Differentiated ◽  
Central Nervous Sytem ◽  
Plexus Papilloma

Choroid plexus tumors are rare intracranial tumors which account for 0.4-0.6% of all brain tumors. Choroid plexus tumors represent a spectrum of neoplasms derived from papillary epithelium of normal choroid plexus, including well-differentiated papilloma (WHO grade I), intermediate form as atypical Choroid Plexus Papilloma (WHO grade II) and highly aggressive choroid plexus carcinomas (WHO grade III). Though rare, it is responsible for the communicating hydrocephalus in children due to overproduction of cerebrospinal fluid. Due to advances in molecular biology and better understanding of the tumorigenesis of choroid plexus papilloma, now it is established that several genetic syndromes and central nervous sytem abnormalities are associated with this tumor. Here, we reported a case of a 10 months old child who presented with sudden deterioration of consciousness level and after thorough evaluation, diagnosed as a case of Choroid Plexus Papilloma with Dandy Walker Variant. Till date, this is the first reported case of the association/ co-existence of such two conditions which needs further evaluation. Bangladesh Med J. 2017 May; 46 (2): 61-65

scholarly journals RARE-26. RETROSPECTIVE ANALYSIS OF PEDIATRIC CHOROID PLEXUS TUMORS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii447-iii448
Author(s):  
Yoshiko Nakano ◽  
Atsufumi Kawamura ◽  
Yuko Watanabe ◽  
Ryuta Saito ◽  
Masayuki Kanemori ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Survival Rates ◽  
Choroid Plexus Papilloma ◽  
Clinical Information ◽  
Local Relapse ◽  
Current Status ◽  
Choroid Plexus Tumors ◽  
Li Fraumeni Syndrome ◽  
Plexus Papilloma

Abstract BACKGROUND Choroid plexus tumors (CPT) include choroid plexus papilloma (CPP), atypical choroid plexus papilloma (aCPP), and choroid plexus carcinoma (CPC). Because of their rarity, limited data are available on the current status of treatment and outcomes for pediatric CPTs. METHOD We retrospectively reviewed clinical information on patients with CPT patients aged between 0 and 30 years at diagnosis and were treated in 8 institutions in Japan. RESULTS Of forty-two cases initially diagnosed as CPT, 18 cases were reviewed by central pathologists. As a result, the diagnosis of CPC or aCPP in five cases were changed to other tumors including AT/RT and astroblastoma. The remaining 37 cases were subjected to analysis. Median age at diagnosis was two years (0 to 25) and the mean follow-up period was seven years. All 26 patients with CPP (n=20) or aCPP (n=6) underwent gross-total resection without adjuvant therapy. Of them 24 patients are alive without recurrence. Four patients of patients with CPC (n=11) died of cancer. Five patients including three patients experienced local relapse, achieved complete remission after resection of tumor plus chemoradiotherapy. All three patients with dissemination of CPC at diagnosis or relapse died of the disease. At least three patients were diagnosed with Li-Fraumeni syndrome: one died of medulloblastoma and one patient developed osteosarcoma. CONCLUSION Compared with the excellent prognosis of CPP, the survival rates for CPC, especially disseminated CPC are unsatisfactory. Our results also underline the importance of considering genetic testing of TP53 for patients with CPC.

Intraventricular Cavernous Hemangioma: Report of Three Cases and Review of the Literature

Neurosurgery ◽  
1985 ◽  
Vol 16 (2) ◽  
pp. 189-197 ◽  
Author(s):  
William M. Chadduck ◽  
Eugene F. Binet ◽  
Fank W. Farrell ◽  
Carlos A. Araoz ◽  
David L. Reding
Keyword(s):  
Differential Diagnosis ◽  
Arteriovenous Malformation ◽  
Choroid Plexus ◽  
Cavernous Hemangioma ◽  
Choroid Plexus Papilloma ◽  
Low Grade ◽  
Review Of The Literature ◽  
Intraventricular Meningioma ◽  
Radiographic Presentation ◽  
Plexus Papilloma

Abstract The clinical and radiographic presentations of 3 patients with intraventricular cavernous hemangioma are described. The accumulated total of 19 cases from the literature are compared to determine whether there is a common clinical and radiographic presentation for this benign intraventricular lesion. The differential diagnosis of intraventricular cavernous hemangioma includes intraventricular meningioma, choroid plexus papilloma, arteriovenous malformation, low grade astrocytoma, and ependymoma.

Primary Choroid Plexus Papilloma of the Cerebellopontine Angle

Neurosurgery ◽  
1983 ◽  
Vol 12 (3) ◽  
pp. 334-336 ◽  
Author(s):  
Richard C. Chan ◽  
Gordon B. Thompson ◽  
Felix A. Durity
Keyword(s):  
Differential Diagnosis ◽  
Radiation Therapy ◽  
Choroid Plexus ◽  
Cerebellopontine Angle ◽  
Choroid Plexus Papilloma ◽  
Cervical Region ◽  
Upper Cervical ◽  
Tentorial Notch ◽  
Plexus Papilloma

Abstract A case of choroid plexus papilloma of the cerebellopontine angle, extending from the upper cervical region to the level of the tentorial notch, in a 50-year-old woman is presented. The differential diagnosis of tumors in the cerebellopontine angle and the role of surgical treatment vs. radiation therapy are discussed.

scholarly journals RARE-18. GENETIC EVALUATION IN PATIENTS WITH CHOROID PLEXUS TUMORS

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii446-iii446
Author(s):  
Milena Oliveira ◽  
Nasjla Silva ◽  
Andrea Cappellano ◽  
Daniela Almeida ◽  
Sergio Cavalheiro ◽  
...  
Keyword(s):  
Family History ◽  
Choroid Plexus ◽  
P53 Protein ◽  
Positive Family History ◽  
Choroid Plexus Papilloma ◽  
Tp53 Gene ◽  
Genetic Evaluation ◽  
Choroid Plexus Tumors ◽  
Li Fraumeni Syndrome ◽  
Plexus Papilloma

Abstract INTRODUCTION Choroid plexus tumors (CPT) are rare intraventricular neoplasms of epithelial origin. They usually occur in the 2nd year of life, corresponding to 0.4–0.6% of intracranial tumors in this age group. They are sub classified, according to WHO 2016, in choroid plexus carcinoma (CPC), atypical choroid plexus papilloma (ACPP) and choroid plexus papilloma (CPP). Li-Fraumeni syndrome (LFS) is present in 50% of patients with CPC. In Brazil, the TP53 p.R337H mutation affects 0.3% of the population in the South/Southeast. OBJECTIVE Evaluate the incidence of genetic mutations in patients with choroid plexus tumors and therefore the importance of genetic evaluation. PATIENTS AND METHODS Between 1992–2019, 38 patients were diagnosed with CPT in our institution, 23 with CPC. From 2012, 21 patients were referred for genetic evaluation, 16 of which had CPC (2 had previously CPP). Positive family history for neoplasms was present in 87.5%; 37.5% compatible with LFS, 50% of them with mutations. All the patients with positive, but unspecific, family history of neoplasms, had pathogenic mutation. The molecular investigation of the TP53 gene in patients with CPC was performed and positive in 56.2%: R337H (5 patients), R110C, R158H, H179R, R196* (1 patient each). Of those with R337H, p53 protein immunohistochemistry resulted in 90–100% positivity. One of the patients with CPP that evolved to CCP had the H179R mutation. Clinical course was similar among them, and with those without mutations. CONCLUSION These results confirm the need for genetic evaluation in patients with choroid plexus tumors for adequate therapeutic management and long-term follow-up.

Adult choroid plexus papilloma of the posterior fossa mimicking a hemangioblastoma

2000 ◽  
Vol 92 (5) ◽  
pp. 870-872 ◽  
Author(s):  
Roberto García-Valtuille ◽  
Faustino Abascal ◽  
Ana I. García-Valtuille ◽  
J. Ignacio Pinto ◽  
Luis Cerezal ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Magnetic Resonance ◽  
Choroid Plexus ◽  
Posterior Fossa ◽  
Choroid Plexus Papilloma ◽  
Mr Images ◽  
Content Type ◽  
Tomography Imaging ◽  
Fine Print ◽  
Plexus Papilloma

✓ The authors report a case of cystic choroid plexus papilloma that originated in the posterior fossa. No connection with the ventricular system was found intraoperatively. Magnetic resonance (MR) and computerized tomography imaging did not furnish a diagnosis, but findings of pathological examinations were consistent with those of choroid plexus papilloma. The authors describe the different appearances of the tumor on MR images and discuss the differential diagnosis with other tumors of the posterior fossa.

MR Findings of Choroid Plexus Papilloma: Case Report

1994 ◽  
Vol 30 (4) ◽  
pp. 643
Author(s):  
Joo Hyeong Oh ◽  
Tae Hoon Kim ◽  
Woo Suk Choi
Keyword(s):  
Case Report ◽  
Choroid Plexus ◽  
Choroid Plexus Papilloma ◽  
Plexus Papilloma
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