Clinical Analysis of Eighty-Eight Cases of Metastatic Carcinoma Involving the Central Nervous System

1949 ◽  
Vol 6 (6) ◽  
pp. 495-502 ◽  
Author(s):  
Arthur R. Elvidge ◽  
Maitland Baldwin
2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Meifang Yang ◽  
Xuan Zhang ◽  
Jianhua Hu ◽  
Hong Zhao ◽  
Lanjuan Li

Background. Cryptococcosis following kidney transplantation (KT) is rare but is associated with considerably increased risk of mortality. At present, data on the association between cryptococcosis and KT in mainland China remain relatively limited. Objectives. This study aims to review our experience related to the management of cryptococcosis following KT at a Chinese tertiary hospital. Methods. All patients with cryptococcosis following KT admitted to our hospital from January 2010 to December 2018 were reviewed. Results. A total of 37 patients with cryptococcosis were enrolled (males: 62.2%). The mean age of the patients was 49.5 ± 9.38 (20–64) years. The average time to infection following KT was 7.0 ± 5.50 years (5 months to 21 years), and 30 patients (81.1%) had cryptococcosis onset >2 years following transplantation. The most common site of infection was the central nervous system, followed by the pulmonary system and skin. Most patients received fluconazole or voriconazole with or without flucytosine as their initial treatment regimen at our hospital. The 2-week mortality rate was 8.1% (3/37), and five patients (13.5%) died within 6 months of being diagnosed with cryptococcosis. Remarkably, all patients who received high-dose fluconazole (800 mg daily) or voriconazole ± flucytosine survived. Conclusions. Cryptococcosis in kidney transplant recipients is typically a late-occurring infection, with most patients having cryptococcosis onset >2 years following KT at our hospital. The central nervous system, pulmonary system, and skin are the main sites of infection. Voriconazole or high-dose fluconazole can be used as an alternative therapy for post-KT cryptococcosis.


1998 ◽  
Vol 18 (4) ◽  
pp. 370-375
Author(s):  
Tatsuo Sawada ◽  
Yoshinori Takekawa ◽  
Isamu Sakurai ◽  
Makio Kobayashi

2020 ◽  
Vol 148 (3-4) ◽  
pp. 223-226
Author(s):  
Ivana Stojic ◽  
Dalibor Ilic ◽  
Mirela Jukovic ◽  
Milos Vujanovic ◽  
Ivana Canak ◽  
...  

Introduction. Infectious or non-infectious noxae may occur in drug-addicted patients who have clinical presentation of meningeal syndrome with a spectrum of possible complications, such as a diffuse or focal brain lesions. The objective of this report is to present a rare case of a drug-addicted male patient, initially suspected of mycosis of the central nervous system, but computed tomography (CT) and magnetic resonance imaging (MRI) showed the signs of an invasive neurosurgical operation that the patient underwent during the treatment of drug addiction. Case outline. A 37-year-old male patient was hospitalized at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, with a meningeal syndrome, initially suspected of mycosis of the central nervous system. He was diagnosed at the Center for Radiology. Neuroimaging ? CT and MRI were used in order to prove or disprove the presence of brain infection. These diagnostic procedures ruled out the presence of brain infection, but opened questions about the type of neurosurgical treatment performed out of legal institution, due to the presence of craniotomy and focal glial brain lesions in the frontal lobes. Conclusion. In drug-addicted patients, meningeal syndrome can be connected with diffuse or focal brain infections. Together with laboratory and clinical analysis, imaging methods contribute to the decision making and optimal treatment of patients. In our case, CT and MRI made a significant contribution in the detection of the focal brain lesions and clarification of their etiology.


2013 ◽  
Vol 155 (10) ◽  
pp. 1839-1847 ◽  
Author(s):  
Chenlong Yang ◽  
Guang Li ◽  
Jingyi Fang ◽  
Liang Wu ◽  
Xiaofeng Deng ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document