Multiple nevoid basal-cell carcinoma syndrome (Gorlin's syndrome): Possible confusion with metastatic medulloblastoma

1979 ◽  
Vol 50 (1) ◽  
pp. 100-102 ◽  
Author(s):  
John C. Hawkins ◽  
Harold J. Hoffman ◽  
Laurence E. Becker
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Total Excision ◽  
Diagnostic Dilemma ◽  
Content Type ◽  
X Ray ◽  
Lytic Lesions ◽  
Fine Print

✓ The authors report a diagnostic dilemma involving a child who, 8 years previously, had total excision of a medulloblastoma. On x-ray studies, lytic lesions of the skull were seen. The differential diagnosis and some of the clinical and pathological aspects of the nevoid basal-cell carcinoma syndrome versus metastases are discussed.

Neurological involvement in the nevoid basal cell carcinoma syndrome

1971 ◽  
Vol 35 (5) ◽  
pp. 577-584 ◽  
Author(s):  
Charles R. Neblett ◽  
Thomas A. Waltz ◽  
David E. Anderson
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Neurological Involvement ◽  
Content Type ◽  
The Central Nervous System ◽  
Associated Abnormalities ◽  
Fine Print

✓ Four patients who had medulloblastomas in association with the nevoid basal cell carcinoma syndrome are reported, for a total of six known cases. Involvement of the central nervous system appears to be an integral component of this syndrome. The medulloblastoma appear earlier in life (50% of the patients are less than 2 years old), and the prognosis appears to be better (five of the six are still living). Possible reasons for these features are considered, and other associated abnormalities are discussed.

Basosquamous or Basal Cell Carcinoma? The Importance of the Differential Diagnosis

2015 ◽  
Vol 26 (6) ◽  
pp. 2026-2027 ◽  
Author(s):  
Valentina Terenzi ◽  
Andrea Cassoni ◽  
Marco M Della ◽  
Daniela Musio ◽  
Francesca De Felice ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell

scholarly journals Ocular myiasis in a glioma: A case report

2017 ◽  
Vol 15 (3) ◽  
Author(s):  
David J Mathew ◽  
Satheesh Solomon T Selvin ◽  
Shilpa E Kuruvilla ◽  
Thomas Kuriakose
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Living Conditions ◽  
Total Excision ◽  
Ischemic Necrosis ◽  
Manual Removal ◽  
Low Levels

Ocular myiasis though rare, is usually found in association with basal cell carcinoma. It is rarer still in tumors other than basal cell carcinoma. We report a case of ocular myiasis in a glioma which is hitherto unreported to the best of our knowledge. A 50 year old male presented with bleeding and maggots emanating from a tumourous outgrowth which had replaced his right eye. He complained of swelling and pain in his right for the last 2 years. Manual removal of maggots was carried out following which he underwent total excision of the mass and local debridement. Biopsy of the mass was consistent with astrocytoma. Myiasis though rare should be suspected in long standing neglected lesions with suggestive history. Infection, ischemic necrosis and malignancy coupled with overcrowding, poor living conditions, presence of excessive arthropods in the locality and low levels of hygiene drastically increase the risk of myiasis.

scholarly journals Head and neck basal cell carcinoma prevalence in individuals submitted to childhood X-ray epilation for tinea capitis treatment

2012 ◽  
Vol 22 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Paula Boaventura ◽  
Rosa Oliveira ◽  
Dina Pereira ◽  
Paula Soares ◽  
José Teixeira-Gomes
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Basal Cell ◽  
Tinea Capitis ◽  
X Ray

CD10, TDAG51, CK20, AR, INSM1, and Nestin Expression in the Differential Diagnosis of Trichoblastoma and Basal Cell Carcinoma

2018 ◽  
Vol 27 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Cem Leblebici ◽  
Buket Bambul Sığırcı ◽  
Canan Kelten Talu ◽  
Sevim Baykal Koca ◽  
Gülben Erdem Huq
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
The Other ◽  
Cytokeratin 20 ◽  
Nestin Expression ◽  
The Difference ◽  
Nevus Sebaceous ◽  
Sensitive Marker

Background. Trichoblastoma (TB) and basal cell carcinoma (BCC) are 2 different neoplasms composed of basaloid cells and have overlapping histopathological features. We compared the immunoexpression of CD10, T-cell death-associated gene 51 (TDAG51), cytokeratin 20 (CK20), androgen receptor (AR), insulinoma-associated protein 1 (INSM1), and nestin for the differential diagnosis of these tumors. Materials and Methods. We assessed a total of 27 BCC and 27 TB cases, including 4 TB lesions in nevus sebaceous and 3 malignant TB lesions for CD10, TDAG51, CK20, AR, INSM1, and nestin expression. Results. Staining for CK20, TDAG51, INSM1, and stromal CD10 was significantly more common in TB cases than in BCC cases ( P < .001). Epithelial CD10 and AR staining was significantly more common in BCC cases than in TB cases ( P < .001). The difference between the groups for nestin staining was not significant ( P > .05). Stromal CD10 staining was the most sensitive marker (96.3%) and INSM1 the least sensitive (55.6%) marker for TB. TDAG51 showed 100% specificity for TB. A larger number of CK20 positive cells was found in the cases associated with nevus sebaceous than in the other TBs. Conclusion. All the selected markers except nestin were useful for the differential diagnosis between TB and BCC. CD10 and TDAG51 were more useful than the other markers. The use of CK20 could be preferred in nevus sebaceous lesions. INSM1 was less effective in highlighting Merkel cells within the lesion than CK20.

Bcl-2 and CD10 expression in the differential diagnosis of trichoblastoma, basal cell carcinoma, and basal cell carcinoma with follicular differentiation

2009 ◽  
Vol 48 (7) ◽  
pp. 713-717 ◽  
Author(s):  
Alicia Córdoba ◽  
David Guerrero ◽  
Begoña Larrinaga ◽  
Maria Eugenia Iglesias ◽  
Maria Asunción Arrechea ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Cd10 Expression

Multiple neoplasms following craniospinal irradiation for medulloblastoma in a patient with nevoid basal cell carcinoma syndrome

1997 ◽  
Vol 86 (2) ◽  
pp. 286-288 ◽  
Author(s):  
Sean O'Malley ◽  
David Weitman ◽  
Michael Olding ◽  
Laligam Sekhar
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Subsequent Development ◽  
Craniospinal Irradiation ◽  
Malignant Neoplasms ◽  
Content Type ◽  
Multiple Neoplasms ◽  
Gorlin’S Syndrome ◽  
Gorlin's Syndrome

✓ A 28-year-old man presented to the authors' hospital with multiple intracranial tumors. At 2 years of age, he had undergone resection of a medulloblastoma and received adjunctive craniospinal irradiation. Subsequently, he was diagnosed with nevoid basal cell carcinoma syndrome, Gorlin's syndrome. Since his first presentation, he has required surgery for multiple basal cell carcinomas, an osteochondroma of the rib, two meningiomas, a trigeminal schwannoma, and a pleomorphic liposarcoma, all of which arose within the radiation field. Despite this impressive list of benign and malignant neoplasms, the patient is relatively well and leads a normal life. The authors examine the relationships between Gorlin's syndrome and radiation therapy and the subsequent development of tumors.

Statistical evaluation of epiluminescence microscopy criteria in the differential diagnosis of malignant melanoma and pigmented basal cell carcinoma

1997 ◽  
Vol 7 (4) ◽  
pp. 307-312 ◽  
Author(s):  
M P??sp??k-Schwarz ◽  
A Steiner ◽  
M Binder ◽  
B Partsch ◽  
K Wolff ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Malignant Melanoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Statistical Evaluation
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