Capillary hemangioma of the central nervous system

2004 ◽  
Vol 101 (1) ◽  
pp. 73-81 ◽  
Author(s):  
Masamitsu Abe ◽  
Kazuo Tabuchi ◽  
Shin Tanaka ◽  
Akira Hodozuka ◽  
Katsuzo Kunishio ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Capillary Hemangioma ◽  
Benign Tumors ◽  
Content Type ◽  
Perifocal Edema ◽  
The Central Nervous System ◽  
The Brain ◽  
Fine Print

Object. Capillary hemangiomas are benign tumors or tumorlike lesions that originate from blood vessels and have rarely been reported to develop in the brain or spinal cord. The authors summarize the clinical and histological features of capillary hemangiomas of the central nervous system (CNS). Methods. The clinical features, imaging characteristics, and outcomes in 10 patients with CNS capillary hemangiomas were reviewed. Histological studies included immunostaining with CD31, α-smooth muscle actin, vascular endothelial growth factor, and Ki-67 antigen. Three patients with lesions in the brain presented with symptoms of increased intracranial pressure or seizures. Seven patients with lesions in the spinal cord presented with progressive sensorimotor disturbances of the lower limbs. Computerized tomography and magnetic resonance imaging demonstrated well-defined, enhancing lesions associated with marked perifocal edema. Angiography demonstrated hypervascular lesions, which have not recurred after resection. In two cases, multiple satellite lesions resolved after the systemic administration of steroid drugs or interferon-α. Histologically, all lesions were consistent with findings of capillary hemangioma of the skin or soft tissues. The CNS lesions differed significantly from other vascular neoplasms, such as hemangioendotheliomas, hemangiopericytomas, and hemangioblastomas. Conclusions. Capillary hemangiomas of the CNS are benign lesions that can be surgically removed and cured without adjuvant therapy.

scholarly journals Malignant lymphoma of the central nervous system presenting with central neurogenic hyperventilation

1992 ◽  
Vol 76 (4) ◽  
pp. 696-700 ◽  
Author(s):  
Yasushi Shibata ◽  
Kotoo Meguro ◽  
Kiyoshi Narushima ◽  
Fumiho Shibuya ◽  
Mikio Doi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Malignant Lymphoma ◽  
Diffuse Infiltration ◽  
Content Type ◽  
The Central Nervous System ◽  
Entire Central Nervous System ◽  
Radiological Studies ◽  
Fine Print

✓ The case is described of a 72-year-old woman who presented with a progressive right hemiparesis and central neurogenic hyperventilation. Pathological and radiological studies revealed diffuse infiltration of a malignant lymphoma into the entire central nervous system and the upper spinal cord. The authors review 12 cases of tumor-induced central neurogenic hyperventilation and discuss the pathophysiology of this condition.

Primary demyelinating disease simulating glioma of the corpus callosum

1981 ◽  
Vol 55 (4) ◽  
pp. 620-624 ◽  
Author(s):  
Kenneth G. Rieth ◽  
Giovanni Di Chiro ◽  
Laurence D. Cromwell ◽  
Paul E. McKeever ◽  
Paul L. Kornblith ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Corpus Callosum ◽  
Demyelinating Disease ◽  
Mass Effect ◽  
Periventricular White Matter ◽  
Content Type ◽  
The Central Nervous System ◽  
The Brain ◽  
Fine Print

✓ Computerized tomography (CT) has made it easier to distinguish tumoral from nontumoral diseases of the central nervous system. In the presence of mass effect, however, this distinction may be difficult or impossible to make. Primary demyelinating disease may occasionally present as a focal cerebral mass. The authors report three cases of primary demyelinating disease of the brain involving the corpus callosum and periventricular white matter and associated with mass effect, which proved difficult to differentiate from infiltrating “butterfly” gliomas.

Surface properties, more than size, limiting convective distribution of virus-sized particles and viruses in the central nervous system

2005 ◽  
Vol 103 (2) ◽  
pp. 311-319 ◽  
Author(s):  
Michael Y. Chen ◽  
Alan Hoffer ◽  
Paul F. Morrison ◽  
John F. Hamilton ◽  
Jeffrey Hughes ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Gray Matter ◽  
Extracellular Space ◽  
Invasive Technique ◽  
Major Barrier ◽  
Content Type ◽  
The Central Nervous System ◽  
The Brain ◽  
Fine Print

Object. Achieving distribution of gene-carrying vectors is a major barrier to the clinical application of gene therapy. Because of the blood—brain barrier, the distribution of genetic vectors to the central nervous system (CNS) is even more challenging than delivery to other tissues. Direct intraparenchymal microinfusion, a minimally invasive technique, uses bulk flow (convection) to distribute suspensions of macromolecules widely through the extracellular space (convection-enhanced delivery [CED]). Although acute injection into solid tissue is often used for delivery of oligonucleotides, viruses, and liposomes, and there is preliminary evidence that certain of these large particles can spread through the interstitial space of the brain by the use of convection, the use of CED for distribution of viruses in the brain has not been systematically examined. That is the goal of this study. Methods. Investigators used a rodent model to examine the influence of size, osmolarity of buffering solutions, and surface coating on the volumetric distribution of virus-sized nanoparticles and viruses (adeno-associated viruses and adenoviruses) in the gray matter of the brain. The results demonstrate that channels in the extracellular space of gray matter in the brain are large enough to accommodate virus-sized particles and that the surface characteristics are critical determinants for distribution of viruses in the brain by convection. Conclusions. These results indicate that convective distribution can be used to distribute therapeutic viral vectors in the CNS.

Superficial siderosis of the central nervous system: magnetic resonance imaging and pathological correlation

1993 ◽  
Vol 79 (5) ◽  
pp. 756-760 ◽  
Author(s):  
Anna J. Janss ◽  
Steven L. Galetta ◽  
Andrew Freese ◽  
Eric C. Raps ◽  
Mark T. Curtis ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Magnetic Resonance ◽  
Brain Stem ◽  
Superficial Siderosis ◽  
Mr Images ◽  
Content Type ◽  
The Central Nervous System ◽  
Fine Print

✓ The authors report a 32-year-old woman who had undergone repair of an occipital encephalocele in infancy and who experienced a 20-year history of progressive hearing loss and intermittent vertigo. After parturition, she developed a rapidly progressive quadriparesis and brain-stem dysfunction associated with persistent intraventricular and subarachnoid hemorrhage. Serial magnetic resonance (MR) images showed progressive deposition of hemosiderin along the surface of the brain, brain stem, and spinal cord, and enhanced thickened membranes at the site of the original encephalocele repair. Posterior fossa exploration disclosed hemorrhagic membranes, which were resected; despite removal of this tissue, the patient deteriorated and died. Postmortem examination confirmed iron-containing pigment along the meninges, cerebral hemispheres, brain stem, spinal cord, and cranial nerves accompanied by atrophy of the superficial cerebellar cortex. It is concluded that superficial siderosis may accompany encephalocele repair. This is believed to be the first report in the literature of superficial siderosis of the central nervous system to correlate in vivo MR images with autopsy results.

Isolated intramedullary histiocytosis-X of the cervical spinal cord

1995 ◽  
Vol 83 (4) ◽  
pp. 716-718 ◽  
Author(s):  
Bruce Hamilton ◽  
Edward S. Connolly ◽  
William T. Mitchell
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Cervical Spinal Cord ◽  
Histiocytosis X ◽  
Content Type ◽  
First Case ◽  
The Central Nervous System ◽  
Fine Print

✓ Histiocytosis-X is known to involve the central nervous system, but rarely does this disease involve the spinal cord. To the authors' knowledge, this is the first case of isolated intramedullary histiocytosis-X of the spinal cord to be reported.

Nasal glioma and encephalocele: two separate entities

1986 ◽  
Vol 64 (3) ◽  
pp. 516-519 ◽  
Author(s):  
Mohammod Younus ◽  
Peter E. Coode
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Malignant Tumor ◽  
Malignant Potential ◽  
Developmental Abnormality ◽  
Content Type ◽  
Nasal Glioma ◽  
The Central Nervous System ◽  
The Brain ◽  
Fine Print

✓ The term “nasal glioma” is a confusing misnomer as it implies a neoplastic condition with malignant potential, which it is not. Nasal glioma is a rare developmental abnormality and should be differentiated from glioma, which is a malignant tumor of the brain, and from a primary encephalocele, which is herniation of the cranial contents through a bone defect in the skull, through which it retains an intact connection with the central nervous system. Two cases of nasal glioma, one with and one without intracranial connections, are described and the literature is reviewed.

Primary (granulomatous) angiitis of the central nervous system with multiple aneurysms of spinal arteries

1993 ◽  
Vol 79 (4) ◽  
pp. 603-607 ◽  
Author(s):  
Meow F. Yoong ◽  
Peter C. Blumbergs ◽  
J. Brian North
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Lymphoid Tissue ◽  
Tissue Type ◽  
Subdural Hemorrhage ◽  
Granulomatous Angiitis ◽  
Content Type ◽  
The Central Nervous System ◽  
Fine Print

✓ A 55-year-old woman with primary (granulomatous) angiitis of the central nervous system in association with non-Hodgkin's lymphoma (mucosa-associated lymphoid tissue type) presented with an acute spinal subdural hemorrhage secondary to rupture of one of several fusiform inflammatory aneurysms of the spinal cord radicular arteries. The literature on hemorrhagic complications, aneurysms, and spinal cord involvement in granulomatous angiitis is reviewed. Recognition of granulomatous angiitis is important, as the condition may be responsive to immunosuppressive therapy.

Spinal meningeal melanocytoma presenting with superficial siderosis of the central nervous system

1998 ◽  
Vol 88 (5) ◽  
pp. 890-894 ◽  
Author(s):  
Shigeo Matsumoto ◽  
Yoo Kang ◽  
Shinichi Sato ◽  
Yasuto Kawakami ◽  
Yoshifumi Oda ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Superficial Siderosis ◽  
Thoracic Spinal Cord ◽  
Content Type ◽  
Meningeal Melanocytoma ◽  
Pigmented Lesions ◽  
The Central Nervous System ◽  
Fine Print

✓ Meningeal melanocytoma is a benign melanocytic tumor that originates most frequently from the melanocytes in the posterior fossa or along the spinal cord. This tumor generally occurs as an extraaxial mass that compresses adjacent neural structures to produce various neurological signs. The authors describe an unusual case in which a patient with a meningeal melanocytoma located at the thoracic spinal cord presented with superficial siderosis of the central nervous system (CNS). Extensive neuroradiological studies identified the presence of a spinal cord tumor, and postsurgical histological examination revealed the meningeal melanocytoma as a bleeding source. After surgery, lumbar puncture demonstrated normalization of the patient's cerebrospinal fluid; however, no neurological improvement occurred. The neurological deficits seem irreversible. Meningeal melanocytoma is biologically benign and can be cured by complete surgical resection; therefore, this tumor should be included in the differential diagnosis of pigmented lesions of the CNS. The authors reviewed 14 cases of well-documented meningeal melanocytoma in the literature and discuss the clinical, radiological, and pathological features of the present case to emphasize the importance of early diagnosis and identification of the source of bleeding in patients with superficial siderosis.

Radiological features of the meningoradicular metastases of tumors of the central nervous system

1973 ◽  
Vol 38 (5) ◽  
pp. 627-630
Author(s):  
Jean Pecker ◽  
Jacques Simon ◽  
Gilles Guy ◽  
Michel Carsin ◽  
Michel Jan
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Cauda Equina ◽  
Intracranial Tumors ◽  
Content Type ◽  
Radiological Features ◽  
The Central Nervous System ◽  
Radiological Studies ◽  
Fine Print

✓ The authors present two cases of intracranial tumors that metastasized through the CSF to the spinal cord and its roots, and discuss the value and hazards of radiological studies in making the diagnosis. Medulloblastomas, pinealomas, and ependymomas are the most common intracranial tumors to metastasize in this fashion. The metastases usually locate in the dural fundus and roots of the cauda equina due to the hydrodynamics of the CSF.

Central Nerve System Impairment, AMA Guides, Sixth Edition: An Overview

2018 ◽  
Vol 23 (1) ◽  
pp. 10-13
Author(s):  
James B. Talmage ◽  
Jay Blaisdell
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Neurological Impairment ◽  
Sixth Edition ◽  
Central Nerve System ◽  
The Central Nervous System ◽  
The One ◽  
Nerve System ◽  
The Brain

Abstract Injuries that affect the central nervous system (CNS) can be catastrophic because they involve the brain or spinal cord, and determining the underlying clinical cause of impairment is essential in using the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides), in part because the AMA Guides addresses neurological impairment in several chapters. Unlike the musculoskeletal chapters, Chapter 13, The Central and Peripheral Nervous System, does not use grades, grade modifiers, and a net adjustment formula; rather the chapter uses an approach that is similar to that in prior editions of the AMA Guides. The following steps can be used to perform a CNS rating: 1) evaluate all four major categories of cerebral impairment, and choose the one that is most severe; 2) rate the single most severe cerebral impairment of the four major categories; 3) rate all other impairments that are due to neurogenic problems; and 4) combine the rating of the single most severe category of cerebral impairment with the ratings of all other impairments. Because some neurological dysfunctions are rated elsewhere in the AMA Guides, Sixth Edition, the evaluator may consult Table 13-1 to verify the appropriate chapter to use.

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