scholarly journals Urothelial Tumours of the Urinary Bladder: A Histopathological Study of Cystoscopic Biopsies

2013 ◽  
Vol 52 (191) ◽  
Author(s):  
Sujan Vaidya ◽  
Mamata Lakhey ◽  
Sabira KC ◽  
Suspana Hirachand
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Tumour ◽  
Transitional Cell ◽  
Histopathological Study ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Tumours ◽  
Bladder Tumours

Introduction: Bladder tumours constitute one of the most common urological conditions. Urothelial(transitional cell) carcinoma accounts for 90% of all primary tumours of the bladder. These tumoursare an important cause of morbidity and mortality. The objective of this study was to present thehistopathological patterns of urothelial tumours and to determine the grade and stage of thesetumours.Methods: This is a 3 year descriptive study of urothelial tumours carried out in the Departmentof Pathology, Patan Academy of Health Sciences (PAHS), Lalitpur, Nepal. Data of all cystoscopicbiopsies collected during this period were analyzed.Results: Of the 83 urinary bladder tumours, 81 (97.59%) cases were urothelial (transitional cell)tumours. Transitional cell carcinoma (TCC) was the most common bladder tumour which was seenin 67 (80.72%) cases. Thirty two (47.76%) cases of TCC were low grade while 35 (52.24%) were highgrade. Forty three (64.18%) cases of TCC were superficial or in early stage (pTa and pT1) while 24(35.82%) showed muscle invasion.Conclusions: Transitional cell carcinoma was the most common bladder cancer. Most of thesetumours were high grade. A large percentage of high grade carcinomas presented with muscleinvasion. Pathological grade and muscle invasion are the most valuable prognostic predictorsof survival. The importance of including smooth muscle in the biopsy specimens needs to beemphasized._______________________________________________________________________________________Keywords: cancer; high grade; low grade; transitional tumour; urinary bladder._______________________________________________________________________________________

High-Grade Transitional Cell Carcinoma and Melanosis of Urinary Bladder: Case Report and Review of the Literature

Urology ◽  
2009 ◽  
Vol 73 (4) ◽  
pp. 928.e13-928.e15 ◽  
Author(s):  
Sharon L. Sanborn ◽  
Gregory MacLennan ◽  
Matthew M. Cooney ◽  
Ming Zhou ◽  
Lee E. Ponsky
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
High Grade ◽  
Review Of The Literature

Neoadjuvant M-vac in high grade-high stage transitional cell carcinoma (TCC) of the urinary bladder (UB)

1993 ◽  
Vol 29 ◽  
pp. S231
Author(s):  
B. Nussbaum ◽  
A. Figer ◽  
E. Mukamel ◽  
D. Flex ◽  
C Servadio ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
High Grade ◽  
High Stage

scholarly journals Role of serum CA 19-9 as a tumor marker in TCC bladder

2019 ◽  
Vol 7 (4) ◽  
pp. 1239
Author(s):  
Rajeev T. P. ◽  
Nabajeet Das ◽  
S. J. Baruah ◽  
S. K. Barua ◽  
P. K. Bagchi ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Tumor Grade ◽  
Control Group ◽  
High Grade ◽  
Gastrointestinal Malignancies

Background: There is a dearth of reliable blood and urine markers for transitional cell carcinoma of urinary bladder. CA 19-9 is a well-known marker for gastrointestinal malignancies and is being investigated for other malignancies including carcinoma bladder. In this prospective study, we evaluated the role of serum CA 19-9 as a tumor marker and correlated its level with tumor grade and stage.Methods: One hundred and fifteen patients with transitional cell carcinoma of urinary bladder and 69 healthy volunteers, as controls were included in the study. Preoperative blood sample was analysed for level of CA 19-9 using ELISA kit (normal - 0 U/ml to 37U/ml) and were correlated with grade and TNM stage of tumor.Results: The range of the control group is 2-38U/ml (mean: 17.67±9.68U/ml); TCC group is 1-94U/ml (mean: 37.12±31.52U/ml) (p=0.304). When CA 19-9 level >37IU/ml was taken as cut-off for a positive test, sensitivity of detecting T3 disease, T4 disease, MIBC, presence of node and high grade tumour were 80%, 75%, 70.3%, 78% and 57.8% respectively. However, there was a statistically significant increase in levels of CA19-9 in relation to higher grade (<0.001), presence of muscle invasion (<0.001), T stage (<0.001) and N stage (<0.001).Conclusions: Serum CA19-9 is almost invariably raised in patients with high grade and invasive disease. Thus, it has a place as a prognostic marker rather than as a diagnostic tool due to its low sensitivity for TCC bladder.

scholarly journals Nephroureterectomy for Transitional Cell Carcinoma – The Value of Pre-Operative Histology

2008 ◽  
Vol 90 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Sudhanshu Chitale ◽  
Rashidi Mbakada ◽  
Stuart Irving ◽  
Neil Burgess
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Histological Diagnosis ◽  
Low Grade ◽  
High Grade ◽  
Upper Tract ◽  
Ablative Surgery ◽  
Multifocal Disease ◽  
Upper Tract Tcc

INTRODUCTION Nephroureterectomy with excision of a cuff of bladder remains the standard for managing upper tract transitional cell carcinoma (TCC). Increasing use of diagnostic upper tract endoscopy has underlined the importance of obtaining a pre-operative histological diagnosis in order to avoid under-treating high-grade or multifocal disease and over-treating low-grade disease, which could, in selected cases, be managed conservatively. We review nephroureterectomy at our institution over a 10-year period with particular reference to a pre-operative histological diagnosis. PATIENTS AND METHODS Nephroureterectomy was performed in 113 patients from February 1994 to February 2004. Of these cases, 58 were for upper tract TCC and 50 of these 58 had intravenous urography (IVU): 9 had only IVU, 28 had an additional CT scan, 5 had an additional ultrasonography and 8 had additional CT + ultrasonography for pre-operative work-up. Thirty-four of the 58 cases had retrograde pyelography. Nineteen (32.7%) of the 58 cases had a pre-operative ureteroscopy (URS) and biopsy; 14 of these had rigid URS for tumours in the lower (11) and middle (3) thirds of the ureter and 5 had flexible URS for pelvicalyceal tumours by an experienced endourologist. Thirty-one (53%) of the 58 tumours were within the pelvicalyceal system and 27 within the ureter (upper, 5; middle, 3; lower, 19). Forty-eight patients underwent a total nephroureterectomy: 40 had a two incision approach and 8 had an endoscopic resection of the lower ureter. Five of the 58 cases had a sub-total nephroureterectomy and 5 a laparoscopic nephroureterectomy with open excision of lower ureter. RESULTS Nineteen (32.7%) of the 58 patients had a pre-operative histological diagnosis – 17 G2pTa, 1 G1pTa, and 1 G2pT1. Fourteen (74%) biopsies matched the final postoperative histology, but 1 was down-staged, 3 up-staged and 1 up-graded compared to the original histology. Five (12.8%) of 39 patients without pre-operative histology had no TCC in the final surgical specimen: 4 (10.25%) had benign pathology such as capillary haemangioma, urothelial cysts and reactive urothelial changes while one had renal cell carcinoma (RCC). CONCLUSIONS This study underlines the importance of obtaining a pre-operative histological diagnosis in cases with presumed upper tract TCC. Failure to do so can result in unnecessary ablative surgery for benign disease. Such an approach can also help identify multifocality and grade of disease so that treatment of upper tract TCC can be tailored more appropriately with ablative surgery for high-grade or multifocal disease and conservative (endoscopic) therapy for low-grade disease in selected cases. Patients with suspected TCC of the upper tract should be managed at centres where facilities for the comprehensive evaluation of such tumours exist.

MP26-17 T1 HIGH-GRADE (G3) TRANSITIONAL CELL CARCINOMA OF THE URINARY BLADDER: DELAYED RADICAL CYSTECTOMY IS CORRELATED TO A WORSENED OUTCOME

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Birte-Swantje Schneevoigt ◽  
Tobias Grimm ◽  
Alexander Buchner ◽  
Alexander Kretschmer ◽  
Maria Apfelbeck ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Radical Cystectomy ◽  
Transitional Cell ◽  
High Grade

Endourological treatment of large neoplasm in the lower tract of the ureter

1992 ◽  
Vol 59 (1_suppl) ◽  
pp. 104-107
Author(s):  
V. Gramegna ◽  
S. Capizzi ◽  
D. Spalmero ◽  
A. Madaro ◽  
O. Romano ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Pelvis ◽  
Personal Experience ◽  
Transitional Cell ◽  
Low Grade

Conservative endourological treatment of transitional cell carcinoma of renal pelvis and ureter is controversial. The treatment should be reserved for selected cases and for low grade, low stage, monofocal tumors. Personal experience with endourological treatment of a transitional cell carcinoma of the lower tract of the ureter is presented.

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