scholarly journals Role of serum CA 19-9 as a tumor marker in TCC bladder

2019 ◽  
Vol 7 (4) ◽  
pp. 1239
Author(s):  
Rajeev T. P. ◽  
Nabajeet Das ◽  
S. J. Baruah ◽  
S. K. Barua ◽  
P. K. Bagchi ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Tumor Marker ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Tumor Grade ◽  
Control Group ◽  
High Grade ◽  
Gastrointestinal Malignancies

Background: There is a dearth of reliable blood and urine markers for transitional cell carcinoma of urinary bladder. CA 19-9 is a well-known marker for gastrointestinal malignancies and is being investigated for other malignancies including carcinoma bladder. In this prospective study, we evaluated the role of serum CA 19-9 as a tumor marker and correlated its level with tumor grade and stage.Methods: One hundred and fifteen patients with transitional cell carcinoma of urinary bladder and 69 healthy volunteers, as controls were included in the study. Preoperative blood sample was analysed for level of CA 19-9 using ELISA kit (normal - 0 U/ml to 37U/ml) and were correlated with grade and TNM stage of tumor.Results: The range of the control group is 2-38U/ml (mean: 17.67±9.68U/ml); TCC group is 1-94U/ml (mean: 37.12±31.52U/ml) (p=0.304). When CA 19-9 level >37IU/ml was taken as cut-off for a positive test, sensitivity of detecting T3 disease, T4 disease, MIBC, presence of node and high grade tumour were 80%, 75%, 70.3%, 78% and 57.8% respectively. However, there was a statistically significant increase in levels of CA19-9 in relation to higher grade (<0.001), presence of muscle invasion (<0.001), T stage (<0.001) and N stage (<0.001).Conclusions: Serum CA19-9 is almost invariably raised in patients with high grade and invasive disease. Thus, it has a place as a prognostic marker rather than as a diagnostic tool due to its low sensitivity for TCC bladder.

scholarly journals Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder is Associated with Down-Regulated CPP32 Expression and BCL-2 Positivity

2009 ◽  
Vol 28 (2) ◽  
pp. 101-107
Author(s):  
Marija Plješa-Ercegovac ◽  
Jasmina Mimić-Oka ◽  
Dejan Dragičević ◽  
Ana Savić-Radojević ◽  
Marija Matić ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Tumor Grade ◽  
Tumor Stage ◽  
Positive Rate ◽  
Muscle Invasive ◽  
Invasive Transitional Cell Carcinoma

Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder is Associated with Down-Regulated CPP32 Expression and BCL-2 Positivity The objective was to get insight into the role of executive apoptotic enzyme caspase 3 (CPP32) and regulatory antiapoptotic protein Bcl-2 in the malignant phenotype of TCC. Samples were obtained from 84 TCC patients, who underwent transurethral resection, partial or radical cystectomy. Staging showed a superficial growth pattern in 41 patient, while other 43 showed invasive characteristics. Expression of CPP32 and Bcl-2 was determined by immunocytochemistry. Levels of expression were correlated with tumor stage and grade. Expression of CPP32 was positive in 80% of TCC patients. Low-, medium- and high positive status were observed in 18%, 24% and 38% of patients, respectively. There was a signifficant difference in the CPP32 expression between groups with superficial and invasive TCC tumors (p = 0.032), with frequency of CPP32 negative samples being higher and CPP32 high-positive samples being lower in patients with muscle-invasive tumors. Significant association was also found between CPP32 expression and tumor stage (p = 0.043). The positive rate of Bcl-2 protein expression was 48%. There was a statisticaly signifficant difference in the rate of Bcl-2 positivity between superficial and invasive TCC (p = 0.005), with frequency of Bcl-2 positive patients being higher in muscle-invasive TCC. Significant association was also found between Bcl-2 expression and both tumor grade (p=0.032) and stage (p=0.007). Muscle invasive TCC of the urinary bladder is associated with down-regulated expression of CPP32 and Bcl-2 positivity. Down-regulation of CPP32 and up-regulated Bcl-2 might, at least partially, play a role in the development of invasive characteristics of TCC.

High-Grade Transitional Cell Carcinoma and Melanosis of Urinary Bladder: Case Report and Review of the Literature

Urology ◽  
2009 ◽  
Vol 73 (4) ◽  
pp. 928.e13-928.e15 ◽  
Author(s):  
Sharon L. Sanborn ◽  
Gregory MacLennan ◽  
Matthew M. Cooney ◽  
Ming Zhou ◽  
Lee E. Ponsky
Keyword(s):  
Case Report ◽  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
High Grade ◽  
Review Of The Literature

The role of early re-resection in pTaG3 transitional cell carcinoma of the urinary bladder

2011 ◽  
Vol 4 (4) ◽  
pp. 158-165 ◽  
Author(s):  
Nikhil Vasdev ◽  
Christopher McKie ◽  
Jose L. Dominguez-Escrig ◽  
Amira El-Sherif ◽  
Mark I. Johnson ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell

Neoadjuvant M-vac in high grade-high stage transitional cell carcinoma (TCC) of the urinary bladder (UB)

1993 ◽  
Vol 29 ◽  
pp. S231
Author(s):  
B. Nussbaum ◽  
A. Figer ◽  
E. Mukamel ◽  
D. Flex ◽  
C Servadio ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
High Grade ◽  
High Stage

390 ROLE OF KI-67 PROLIFERATION MARKER IN PREDICTING RECURRENCE OF HIGH GRADE TA & T1 BLADDER TRANSITIONAL CELL CARCINOMA

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Mohamed Abdallah ◽  
Ahmed Abdelhalim ◽  
Hala Said ◽  
Tarek Abdelbakey ◽  
Nancy Assad ◽  
...  
Keyword(s):  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
High Grade ◽  
Proliferation Marker ◽  
Bladder Transitional Cell Carcinoma ◽  
Ki 67

scholarly journals Urothelial Tumours of the Urinary Bladder: A Histopathological Study of Cystoscopic Biopsies

2013 ◽  
Vol 52 (191) ◽  
Author(s):  
Sujan Vaidya ◽  
Mamata Lakhey ◽  
Sabira KC ◽  
Suspana Hirachand
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Bladder Tumour ◽  
Transitional Cell ◽  
Histopathological Study ◽  
Low Grade ◽  
High Grade ◽  
Urothelial Tumours ◽  
Bladder Tumours

Introduction: Bladder tumours constitute one of the most common urological conditions. Urothelial(transitional cell) carcinoma accounts for 90% of all primary tumours of the bladder. These tumoursare an important cause of morbidity and mortality. The objective of this study was to present thehistopathological patterns of urothelial tumours and to determine the grade and stage of thesetumours.Methods: This is a 3 year descriptive study of urothelial tumours carried out in the Departmentof Pathology, Patan Academy of Health Sciences (PAHS), Lalitpur, Nepal. Data of all cystoscopicbiopsies collected during this period were analyzed.Results: Of the 83 urinary bladder tumours, 81 (97.59%) cases were urothelial (transitional cell)tumours. Transitional cell carcinoma (TCC) was the most common bladder tumour which was seenin 67 (80.72%) cases. Thirty two (47.76%) cases of TCC were low grade while 35 (52.24%) were highgrade. Forty three (64.18%) cases of TCC were superficial or in early stage (pTa and pT1) while 24(35.82%) showed muscle invasion.Conclusions: Transitional cell carcinoma was the most common bladder cancer. Most of thesetumours were high grade. A large percentage of high grade carcinomas presented with muscleinvasion. Pathological grade and muscle invasion are the most valuable prognostic predictorsof survival. The importance of including smooth muscle in the biopsy specimens needs to beemphasized._______________________________________________________________________________________Keywords: cancer; high grade; low grade; transitional tumour; urinary bladder._______________________________________________________________________________________

scholarly journals Prognostic role of substaging in T1G3 transitional cell carcinoma of the urinary bladder

2014 ◽  
Vol 2 (4) ◽  
pp. 575-580 ◽  
Author(s):  
VINCENZO DE MARCO ◽  
MARIA ANGELA CERRUTO ◽  
CAROLINA D’ELIA ◽  
MATTEO BRUNELLI ◽  
OSCAR OTTE ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Prognostic Role
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