Steroid-Responsive Large Vessel Vasculitis: Application of Whole-Brain 320-Detector Row Dynamic Volume CT Angiography and Perfusion

Objective: To investigate the role of whole-brain volume computed tomography (CT) perfusion in assessing early ischemic cerebrovascular diseases. Materials and Methods: Seventy-two patients with early ischemic cerebrovascular diseases who had undergone routine CT scan and 320-row volume CT whole-brain perfusion imaging within 8 h after admission were retrospectively enrolled in this one-center case-sectional study. The perfusion parameters of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to peak (TTP), and dynamic CT angiogram (4D-CTA) were obtained and analyzed. Results: Among 72 patients, 29 cases with 37 cerebral ischemic lesions were found in plain CT scan, whereas 51 cases with 76 lesions were found in whole-brain CT perfusion, with 30.6% more patients being detected. The CBF value was significantly lower in the abnormal than normal corresponding perfusion area in the healthy hemisphere (P<0.05), while the MTT and TTP values were significantly higher in the abnormal than the normal corresponding area (P<0.05). 4D-CTA image suggested that 59 cases had different degrees of stenosis or occlusion, including 11 mild, 18 moderate, 21 severe, and 9 occlusive cases. Four-D-CTA imaging could detect significantly (P<0.05) more patients with abnormal perfusion in severe cerebral vascular stenosis or occlusion than those with no, mild or moderate stenosis (93.33% vs. 16.67%) (P<0.05). The stenosis of intracranial and carotid arteries was positively correlated with MTT and TTP values (P<0.05). Conclusion: Whole-brain volume CT angiography can comprehensively display early cerebral ischemic lesions, cerebral blood perfusion status, and cerebral vascular stenosis, providing valuable information for early detection of ischemic cerebral diseases and appropriate treatment planning.

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Comparative study of 18F-FDG PET/CT and CT angiography in the detection of large vessel vasculitis

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) ◽

10.1016/j.remnie.2019.06.001 ◽

2019 ◽

Vol 38 (5) ◽

pp. 280-289

Author(s):

M. Moragas Solanes ◽

M. Andreu Magarolas ◽

J.C. Martín Miramon ◽

A.P. Caresia Aróztegui ◽

M. Monteagudo Jiménez ◽

...

Keyword(s):

Comparative Study ◽

Ct Angiography ◽

Fdg Pet ◽

Large Vessel Vasculitis ◽

Large Vessel ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Diagnostic value of four-dimensional CT angiography in arterial erectile dysfunction using 320-detector row dynamic volume CT

Bioscience Reports ◽

10.1042/bsr20170200 ◽

2017 ◽

Vol 37 (4) ◽

Cited By ~ 1

Author(s):

Cheng-Cheng Xu ◽

Xin-Zhong Ruan ◽

Yi-Fan Tang ◽

Jiao-Hai Pan ◽

Guo-Yao Wang ◽

...

Keyword(s):

Erectile Dysfunction ◽

Ct Angiography ◽

Roc Curve ◽

Corpus Cavernosum ◽

Peak Systolic Velocity ◽

Diagnostic Value ◽

Diastolic Velocity ◽

History Of ◽

Volume Ct ◽

Dynamic Volume Ct

The present study aims to evaluate the diagnostic value of four-dimensional CT angiography (4D-CTA) in the diagnosis of arterial erectile dysfunction (ED) using 320-detector row dynamic volume CT. Arterial ED patients attributed to arterial insufficiency were enrolled. To induce penile erection, an intracavernous injection (ICI) of corpus cavernosum with a vasoactive drug was administered. Patients were assigned into the erection hardness score (EHS) 1/2 group or EHS 3/4 group. Color duplex Doppler ultrasound (CDDU) was used to analyze blood flow spectrum. Each patient was examined using 4D-CTA. Receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic value of 4D-CTA in arterial ED. According to Irwin Goldstein, the EHS 3/4 group (n=38) had a shorter course of ED and low proportion with history of hypertension, hyperlipidemia, and diabetes than the EHS 1/2 group (n=35). The peak systolic velocity (PSV), end diastolic velocity (EDV), and resistant index (RI) in the EHS 3/4 group were lower than those of the EHS 1/2 group. 4D-CTA showed there were a total of 35 cases in the EHS 1/2 group (two cases missed) and 38 cases in the EHS 3/4 group (seven cases misdiagnosed). Using 4D-CTA to diagnose arterial ED, the area under the ROC curve yielded a value of 0.879, with a specificity of 93.9% and a sensitivity of 82.5%. These findings indicated that 4D-CTA using 320-detector row dynamic volume CT is a promising and reliable utility in diagnosing arterial ED.

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Optimal systolic and diastolic reconstruction windows for coronary CT angiography using 320-detector rows dynamic volume CT

Clinical Radiology ◽

10.1016/j.crad.2011.02.007 ◽

2011 ◽

Vol 66 (7) ◽

pp. 614-620 ◽

Cited By ~ 13

Author(s):

G. Sun ◽

M. Li ◽

L. Li ◽

G.-y. Li ◽

H. Zhang ◽

...

Keyword(s):

Ct Angiography ◽

Coronary Ct Angiography ◽

Coronary Ct ◽

Volume Ct ◽

Dynamic Volume Ct

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Whole-brain 320-detector row dynamic volume CT perfusion detected crossed cerebellar diaschisis after spontaneous intracerebral hemorrhage

Neuroradiology ◽

10.1007/s00234-014-1456-6 ◽

2014 ◽

Vol 57 (2) ◽

pp. 179-187 ◽

Cited By ~ 10

Author(s):

Jun Fu ◽

Wei-jian Chen ◽

Gui-yun Wu ◽

Jing-liang Cheng ◽

Mei-hao Wang ◽

...

Keyword(s):

Intracerebral Hemorrhage ◽

Ct Perfusion ◽

Spontaneous Intracerebral Hemorrhage ◽

Whole Brain ◽

Crossed Cerebellar Diaschisis ◽

Cerebellar Diaschisis ◽

Volume Ct ◽

Dynamic Volume Ct

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SP0152 Role of Imaging in The Diagnosis and Treatment of Large Vessel Vasculitis

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.6306 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 37.3-37

Author(s):

T. Bley

Keyword(s):

Large Vessel Vasculitis ◽

Large Vessel ◽

Diagnosis And Treatment

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AB0653 Prediction of relapses in autoimmune large-vessel vasculitis – towards personalised immunosuppressive treatment stewardship

10.1136/annrheumdis-2018-eular.5474 ◽

2018 ◽

Author(s):

P.S. Fuchs ◽

M.B. Bigler ◽

C. Küng ◽

T. Manigold ◽

M. Aschwanden ◽

...

Keyword(s):

Immunosuppressive Treatment ◽

Large Vessel Vasculitis ◽

Large Vessel

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Vasculitis: From Target Molecules to Novel Therapeutic Approaches

Biomedicines ◽

10.3390/biomedicines9070757 ◽

2021 ◽

Vol 9 (7) ◽

pp. 757

Author(s):

Sang-Wan Chung

Keyword(s):

Systemic Vasculitis ◽

Alkylating Agents ◽

Large Vessel Vasculitis ◽

Large Vessel ◽

Biologic Therapies ◽

Therapeutic Approaches ◽

Novel Treatments ◽

Treatment Regimens ◽

Immune Mediated ◽

Target Molecules

Systemic vasculitis is a group of diverse diseases characterized by immune-mediated inflammation of blood vessels. Current treatments for vasculitis, such as glucocorticoids and alkylating agents, are associated with significant side effects. In addition, the management of both small and large vessel vasculitis is challenging due to a lack of robust markers of disease activity. Recent research has advanced our understanding of the pathogenesis of both small and large vessel vasculitis, and this has led to the development of novel biologic therapies capable of targeting key cytokine and cellular effectors of the inflammatory cascade. It is anticipated that these novel treatments will lead to more effective and less toxic treatment regimens for patients with systemic vasculitis.

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