A Rapid, Reproducible and Sensitive Levator Ani Test for Anabolic Activity.

ABSTRACT 1. The pharmacological properties of nandrolone decanoate (= caprinate), by abbreviation nor-A. D., have been studied. 2. Nor-A. D. has a marked, long-lasting effect on the levator ani muscle of the castrated rat, but it has little activity on the seminal vesicles and prostate. 3. Nor-A. D. displays only weak gonad inhibiting properties in male and female rats. 4. The anti-oestrogenic activity is low. 5. At high dose levels the anabolic activity becomes maximal and the other effects become evident. The same can be expected to occur if injections are administered with too great a frequency. 6. Chronic toxicity studies in rats and dogs demonstrate its lack of toxicity.

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ORAL ANABOLIC:ANDROGENIC EVALUATIONS OF FOUR ANABOLIC STEROIDS

Acta Endocrinologica ◽

10.1530/acta.0.0520489 ◽

1966 ◽

Vol 52 (3) ◽

pp. 489-496 ◽

Cited By ~ 3

Author(s):

Aaron Arnold ◽

Gordon O. Potts

Keyword(s):

Nitrogen Balance ◽

Anabolic Steroids ◽

Levator Ani ◽

Ventral Prostate ◽

Levator Ani Muscle ◽

Anabolic Activity ◽

Clinical Interest

ABSTRACT Four steroids of potential clinical interest were evaluated in rats for anabolic activity by means of nitrogen balance studies and myotrophically for their effect on the growth of the levator ani muscle. The increase in the weight of the ventral prostate was used as an index of their androgenicity. Under these conditions the nitrogen retention:androgenic and myotrophic:androgenic dissociation ratios were: 17α-methyl-4-chloro-testosterone 0.65:0.12 = 5.4 and 0.32:0.12 = 2.7; 17α-methyl-androst-5-ene-3,17-diol 0.70:0.62 = 1.1 and 0.46:0.62 = 0.7; 17α-methyl-19-nortestosterone 4.6:1.1 = 4.2 and 5.8:1.1 = 5.3; and 1-methyl-androst-1-enolone acetate 0.06:0.15 = 0.004 and 0.72:0.15 = 4.8, respectively. While the nitrogen retention:androgenic and myotrophic:androgenic ratios, in general, are of the same order, it should be noted that there was a marked discrepancy between the nitrogen retention:androgenic and the myotrophic:androgenic ratios for 1-methyl-androst-1-enolone acetate.

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Tetrahydrogestrinone induces a genomic signature typical of a potent anabolic steroid

Journal of Endocrinology ◽

10.1677/joe.1.05997 ◽

2005 ◽

Vol 184 (2) ◽

pp. 427-433 ◽

Cited By ~ 32

Author(s):

Fernand Labrie ◽

Van Luu-The ◽

Ezequiel Calvo ◽

Céline Martel ◽

Julie Cloutier ◽

...

Keyword(s):

Anabolic Steroid ◽

Gastrocnemius Muscle ◽

Mouse Genome ◽

Levator Ani ◽

Levator Ani Muscle ◽

Muscle Weight ◽

Mouse Muscle ◽

Anabolic Activity ◽

Androgenic Activity

Tetrahydrogestrinone (THG) is a recently identified compound having the greatest impact in the world of sports. In order to obtain a highly accurate and sensitive assessment of the potential anabolic/androgenic activity of THG, we have used microarrays to identify its effect on the expression of practically all the 30 000 genes in the mouse genome and compared it with the effect of dihydrotestosterone (DHT), the most potent natural androgen. Quite remarkably, we found that 671 of the genes modulated by THG in the mouse muscle levator ani are modulated in a similar fashion by DHT, while in the gastrocnemius muscle and prostate, 95 and 939 genes respectively, are modulated in common by the two steroids. On the other hand, THG is more potent than DHT in binding to the androgen receptor, while, under in vivo conditions, THG possesses 20% of the potency of DHT in stimulating prostate, seminal vesicle and levator ani muscle weight in the mouse. The present microarray data provide an extremely precise and unquestionable signature of the androgenic/anabolic activity of THG, an approach which should apply to the analysis of the activity of any anabolic steroid.

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ANABOLIC-ANDROGENIC ACTIVITY OF A-RING MODIFIED ANDROSTANE DERIVATIVES.

Acta Endocrinologica ◽

10.1530/acta.0.0530627 ◽

1966 ◽

Vol 53 (4) ◽

pp. 627-634 ◽

Cited By ~ 6

Author(s):

E. F. Nutting ◽

P. D. Klimstra ◽

R. E. Counsell

Keyword(s):

Testosterone Propionate ◽

Levator Ani ◽

Levator Ani Muscle ◽

Reference Standard ◽

Anabolic Activity ◽

Androgenic Activity ◽

Keto Derivative ◽

Relative Potencies ◽

Independent Parameters ◽

Androstane Derivatives

ABSTRACT The activity of 33 steroids, injected intramuscularly, was determined in a castrate rat assay utilizing the responses of the seminal vesicle glands and ventral lobe of the prostate glands as independent parameters of androgenicity and the response of the levator ani muscle as an index of anabolic activity. Testosterone propionate was the reference standard. None of the compounds possessed high androgenic or anabolic activity. The myotrophic and average androgenic relative potencies of the 8 most active analogues ranged from 30 to 89% and 3.1 to 39%, respectively. The most active anabolic compound was the 1-dehydro-3-keto derivative of 17α-methyl-5α-androstan-17β-ol while the widest separation between anabolic and androgenic activities, myotrophic to androgenic ratio of 11.3, was obtained with the 2-dehydro-2-formyl derivative. The effect of various modifications of the A-ring on biological activity are outlined in detail.

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Androgenic and Anabolic Activities of Some Newly Synthesized Epiandrosterone and Progesterone Derivatives.

Scientia Pharmaceutica ◽

10.3797/scipharm.aut-00-13 ◽

2000 ◽

Vol 68 (2) ◽

pp. 141-157 ◽

Cited By ~ 1

Author(s):

Y. A. Maklad ◽

M. M. Nosseir

Keyword(s):

Prostate Gland ◽

Levator Ani ◽

The Body ◽

Ventral Prostate ◽

Piperidine Ring ◽

Albino Rats ◽

Levator Ani Muscle ◽

Anabolic Activity ◽

Androgenic Activity ◽

Derivatives Of

Derivatives of eplandrosterone and progesterone were synthesized. The androgenic and the anabolic activities of some of tlieln were investigated on prepubertal male albino rats of 21 days old by:-i determining tlie weight gain of the body, levator ani muscle, ventral prostate gland, testis, selniilal vesicles, vas deferens and epididymis, ii- estimation of serum luteinizing (LH) hormone, iii- histopatliological examination of the testis and ventral prostate glands. The results from this study showed that the presence of an appended substituted 2- aminopyridine ring at the C- 17 of testosterone gave the maximum androgenic activity, whereas the presence of a substituted piperidine ring fused to ring D of 5 α- androstane exhibited tlie maximum anabolic activity. However, fusion of a pyrazoline moiety with the ring D of 5 α- androstane led to a compound with considerable androgenic and anabolic activity.

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Der akute anale Schmerz

Therapeutische Umschau ◽

10.1024/0040-5930/a000424 ◽

2013 ◽

Vol 70 (7) ◽

pp. 399-402

Author(s):

Olivier Pittet ◽

Nicolas Demartines ◽

Dieter Hahnloser

Keyword(s):

Levator Ani ◽

Klinische Untersuchung ◽

Proctalgia Fugax ◽

Chronische Analfissur ◽

Levator Ani Syndrome

Anale Schmerzen sind häufig in der Proktologie. Eine detaillierte Anamnese der Schmerzen und die klinische Untersuchung führen meistens zur Diagnose und damit zur unmittelbaren Therapie. Die akute Perianalvenenthrombose soll innerhalb 72 Stunden exzidiert werden. Akute Analfissuren werden konservativ mit Stuhlregulation und sphinktertonus-senkender Medikation sehr erfolgreich therapiert. Die chronische Analfissur muss meistens operiert werden. Perinalabaszesse können häufig in Lokalanästhesie abgedeckelt werden. Die proctalgia fugax und das levator ani syndrome sind Auschlussdiagnosen und werden symptomatisch therapiert.

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