Treatment Features of Viral Hepatitis B and C in The Russian Federation

2020 ◽  
Vol 12 (1) ◽  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Russian Federation ◽  
Viral Hepatitis B ◽  
The Russian Federation

scholarly journals Modern Epidemic Situation of Parenteral Viral Hepatitis and Drug Addiction in the Russian Federation and Moscow

2016 ◽  
Vol 15 (2) ◽  
pp. 18-25
Author(s):  
Yu. B. Novikova ◽  
A. A. Asratyan ◽  
E. V. Rusakova
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Retrospective Analysis ◽  
Drug Addiction ◽  
Russian Federation ◽  
Drug Addicts ◽  
Strong Positive Correlation ◽  
Viral Hepatitis B ◽  
The Russian Federation ◽  
First Time

Study aim - a comparative analysis of dynamics and trends in the prevalence of viral hepatitis B and C and drug addiction in Russia and Moscow in the period from 1999 to 2014. Materials and methods. A retrospective analysis of the prevalence of viral hepatitis B and C, and drug addicts was performed among the population of Moscow and the Russian Federation for the period from 1999 to 2014. The forms of federal statistical observation were applied. To assess the significance of differences between the compared values, the statistical significance error (p) were calculated based on the calculation of Student's test (t). Results and discussion. The tendency of growth in prevalence of drug addiction was verified over the study period in Moscow and in Russia as a whole (in Moscow, 166.3 (1999) to 257.37 100 ths people (2013), in Russia 154.75 (1999) to 227.19 100 ths people (2013)). However, the growth rate of drug addiction prevalence has decreased in recent years mainly due to the decrease in the number of patients who applied for medical help for the first time. It was shown that a composition of the consumed drugs has changed in the studied period in Russia: Portion of cannabinoid addiction has decreased in 2 times, the abuse of stimulants in 19 times. The opium addiction compiled the main portion of consumed drugs (74.5%), the poly addiction - 18.3%, the proportion of addiction to stimulants was 3.5%. Epidemiologic features of the of parenteral viral hepatitis B and C was demonstrated: Reduced prevalence of acute forms and an increased incidence of chronic forms of hepatitis B and C in the population of Moscow; changes toward older age in representation of hepatitis B and C; sexual transition was defined as a main transition way for hepatitis B and C. For the first time it shows a very strong positive correlation (r = from 0.95 to 0.96) between the primary drug addiction and the incidence of acute forms of hepatitis B and C in Moscow and the Russian Federation in 2000 - 2013. Conclusion. The retrospective analysis of the prevalence of drug addiction and viral hepatitis B and C showed the presence of common factors affecting the course of the epidemic process in the studied nosology; drug addicts still represent a risk group for infection with viral hepatitis B and C.

scholarly journals Retrospective Analysis of Viral Hepatitis B Incidence in Russia from 2013 to 2017 in the Context of Preventive Vaccination

2018 ◽  
Vol 18 (4) ◽  
pp. 225-235 ◽  
Author(s):  
L. M. Khantimirova ◽  
T. Yu. Kozlova ◽  
E. L. Postnova ◽  
V. A. Shevtsov ◽  
A. V. Rukavishnikov
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Retrospective Analysis ◽  
Russian Federation ◽  
New Technologies ◽  
Immunisation Programme ◽  
Therapeutic Vaccines ◽  
Viral Hepatitis B ◽  
Preventive Vaccination ◽  
The Russian Federation

The article presents the results of a retrospective analysis of viral hepatitis B incidence in the Russian Federation from 2013 to 2017, taking into account the use of vaccines included into the National Immunisation Schedule and the Immunisation Programme in Case of Epidemic Outbreaks. The analysis of the data revealed a trend towards a reduction in the incidence of acute and chronic forms of hepatitis B in the territory of the Russian Federation during the past five years. The reduction of viral hepatitis B incidence was achieved thanks to a higher vaccination coverage of both children and adults. The article presents an overview of monovalent and combination recombinant hepatitis B vaccines licensed in the Russian Federation. It describes the WHO position on preventive vaccination against viral hepatitis B, and pays special attention to vaccination of people at risk. The article considers promising areas for improving immunobiological products for hepatitis B prevention, including new technologies used in vaccine production, development and introduction of new adjuvants or adjuvants systems, and development of therapeutic vaccines.

scholarly journals Variety of the hepatitis B virus genovariants in the military

2019 ◽  
Vol 11 (3) ◽  
pp. 46-53
Author(s):  
Yu. V. Ostankova ◽  
A. V. Semenov ◽  
E. B. Zueva ◽  
I. A. Gabdrakhmanov ◽  
K. V. Kozlov ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Blood Plasma ◽  
Viral Hepatitis ◽  
Russian Federation ◽  
Military Personnel ◽  
Chronic Viral Hepatitis ◽  
B Virus ◽  
Viral Hepatitis B ◽  
The Russian Federation

Aim. To estimate the distribution of genotypes and subgenotypes of the hepatitis B virus among military personnel with chronic viral hepatitis B. Materials and methods. The work used samples of blood plasma and biopsy material obtained from 90 active or retired military personnel with chronic viral hepatitis B with various degrees of fibrosis undergoing treatment in St. Petersburg. Primary detection of HBV was carried out by isolating nucleic acids (NK) from the blood plasma using the «AmplePrime Ribo-prep» commercial kit (FBIS CRIE, Moscow). Specific primers were used for the amplification and sequencing reaction. Overlapping primer pairs were used, jointly flanking 1475 base pairs (bp) fragment, including the recommended for HBV genotyping the 1169 bp Pre-S1/Pre-S2/S. Results. Among 90 samples from patients with chronic viral hepatitis B from different regions of the Russian Federation, HBV subgenotypes are represented in the following ratios: D2 = 45.6% (n=41), D1 = 32.2% (n=29), D3 = 13.3% (n=12), A2 = 6.7% (n=6), D4 and A1 by 1.1%, respectively. The distribution of HBV subgenotypes from the North Caucasian federal district (D1 – 63.6%, D2, D3, D4, A2 – by 9.1%) was significantly different from the distribution among patients from the Central and North-Western federal districts (D1-20, 9%, D2 – 58%, D3 – 16.3%, A2 – 4.8%) (χ2=11,9 при p=0,0076, df=3). Uncharacteristic for the Russian Federation subgenotypes D4 and A1, representing single imported cases. The tendency to shift the distribution of genovariants due to imports of the corresponding HBV subgenotypes from other countries, including the Central Asian countries, is discussed. Conclusion. A systematic study of the HBV isolates phylogeny provides new information about the HBV subgenotypes distribution among certain population groups, including military personnel.

P.455 Current epidemiological characteristic of viral hepatitis B and C in Russian Federation

2006 ◽  
Vol 36 ◽  
pp. S202
Author(s):  
I.V. Schakhguildyan ◽  
M.I. Mikhailov ◽  
O.N. Ershova ◽  
P.A. Khukhlovich ◽  
I.N. Lytkina ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Viral Hepatitis ◽  
Russian Federation ◽  
Epidemiological Characteristic ◽  
Viral Hepatitis B
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