Drug utilization review of third generation cephalosporins in a tertiary care hospital

Background: Drug utilization review plays a key role in helping the healthcare system to understand, interpret and improve the prescribing, administration and use of medications. The principle aim of drug utilization review was to facilitate rational use of drugs, which implies the prescription of a well documented drug in an optimal dose on the right indication.Methods: An observational study of anaesthetic practice was carried out in the department of Anaesthesiology in tertiary care hospital, Varanasi after approval from institutional ethical committee. The data of patients who underwent surgery under general anaesthesia were collected in predesigned patient profile form and were analyzed for drug utilization review.Results: 110 patients were enrolled with mean age 35.30±17.99 years and mean weight 51.32±15.32kg. Laparoscopic cholecystectomy (43.63%), otorhinolaryngology surgeries (36.36%), cardiothoracic vascular surgery (4.54%), neurosurgery (4.54%) and other surgeries (10.93%) required general anaesthetic agents were reviewed. Propofol (93.63%) and etomidate (6.36%) were used for induction of anaesthesia. Propofol (45.45%), isoflurane (53.63%), sevoflurane (0.90%) were administered for maintenance of anaesthesia in various surgeries. Adverse outcomes observed were hypotension (7.27%), bradycardia (6.36%), hypertension (3.63%) and post operative nausea and vomiting (PONV) (2.72%).Conclusions: Propofol is most commonly prescribed drug for induction of anaesthesia. Isoflurane is most commonly prescribed inhalational anaesthetic agent for maintenance of anaesthesia followed by Propofol. Hypotension is most common adverse outcome observed.

Download Full-text

A study on drug utilization evaluation of antibiotics in tertiary care hospital

International Journal of Pharmaceutical Research and Life Sciences ◽

10.26452/ijprls.v8i2.1286 ◽

2020 ◽

Vol 8 (2) ◽

pp. 53-59

Author(s):

Sesham Pushpalatha ◽

Dheeravath Swapna ◽

Antarvedi Moshe ◽

Nagam Venkata Sai Jyothirmai ◽

Tatipamula Vasundhara ◽

...

Keyword(s):

Drug Utilization ◽

Average Cost ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Utilization Review ◽

Care Hospital ◽

Prescribing Pattern ◽

Rational Use ◽

Rational Use Of Antibiotics ◽

Drug Utilization Evaluation

Studies like Drug utilization evaluation have an essential role in finding a prescription pattern of drugs prescribed in hospital for the rational use of antibiotics. An observational study conducted in a tertiary care hospital for six months among 200 patients. The study was conducted to assess prescribing pattern, the average cost of antibiotics prescribed. Also, the ten most commonly prescribed antibiotic’/ 100bed- days and ATC were calculated. Most commonly prescribed antibiotic was , followed by /. The average cost was Rs. 2742.5±25135.19 for the prescribed antibiotics. Pharmacists and physicians play a significant role in decreasing patient problems and the problems related to antibiotics by creating awareness programs related standard prescribing guidelines in the hospital, which results in a reduction of the antibiotic resistance. it is essential to carry out a drug utilization review to study the rational use of antibiotics.

Download Full-text

Epidemiology of Enterobacteriaceae with reduced susceptibility to third-generation cephalosporins isolated from stool screening at entry to a tertiary care hospital

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2008.05.953 ◽

2008 ◽

Vol 12 ◽

pp. e358

Author(s):

J. Chan ◽

D. Lye ◽

Y.S. Leo ◽

T.H. Koh ◽

W.Y. Tang ◽

...

Keyword(s):

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Third Generation ◽

Third Generation Cephalosporins

Download Full-text

Drug utilization review of corticosteroids in a tertiary care hospital of Salem District, Tamilnadu, India

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10i3.1459 ◽

2019 ◽

Vol 10 (3) ◽

pp. 2246-2249

Author(s):

Arul Balasubramanian ◽

Rinson Reji ◽

Rosmy Jose ◽

Sarika Sasidharan ◽

Kothai Ramalingam

Keyword(s):

Drug Utilization ◽

Tertiary Care Hospital ◽

Hormone Replacement ◽

Tertiary Care ◽

General Medicine ◽

Utilization Review ◽

Care Hospital ◽

Utilization Pattern ◽

Inflammatory Conditions ◽

Prescribing Behaviour

Corticosteroids are widely used compounds for allergic reactions, autoimmune diseases, inflammatory conditions, hormone replacement therapy etc. Hence, with widespread use and actions, these have several interactions with drugs and diseases. The purpose of this study was to obtain information about Corticosteroids prescribing and utilization pattern, to understand the prescribing behaviour of physicians and to identify drug interactions. A retrospective observational study was conducted in the department of dermatology and general medicine in a tertiary care hospital for 6 months. All the patients receiving any category of steroid therapy were included, and the prescribing and tapering pattern of steroids were reviewed. Drug utilization pattern (DUR) was observed and analysed among 150 patients during the study period. The results revealed that steroids were prescribed for various respiratory illnesses (66%) and skin-related conditions (34%). The steroid utilization was found to be more in elderly patients, particularly in males. Intravenous administration was common in 33% of cases. Budesonide was the most commonly prescribed steroid (36%), followed by Hydrocortisone (24%) and Dexamethasone (14%). The most frequent drug-drug interaction was between Hydrocortisone and Theophylline as well as Hydrocortisone and Hypoglycaemic agents. Most drugs were prescribed rationally, although some factors like prescribing drugs in the brand name, without mentioning route of administration, frequency and dose were deviating away from rationality. Not much variation was found in the pattern of prescription amongst healthcare professionals. Although most of the drugs were prescribed rationally, the involvement of a clinical pharmacist in patient care can help in more rational prescribing along with prevention and early detection of ADRs which can directly promote drug safety and better patient outcomes.

Download Full-text

Study on drug utilization pattern of antihypertensive medication in tertiary care hospital of Telangana, India

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20183487 ◽

2018 ◽

Vol 7 (9) ◽

pp. 1770

Author(s):

K. Vashishta

Keyword(s):

Calcium Channel ◽

Drug Utilization ◽

Calcium Channel Blockers ◽

Antihypertensive Medication ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Utilization Review ◽

Channel Blockers ◽

Care Hospital ◽

Utilization Pattern

Background: Hypertension is leading cause of deaths in the world. It is the major risk factor for systemic disorders including cardiovascular, renal and brain disorders. A drug utilization review on antihypertensive drugs should be done to determine different classes of antihypertensive medications with respect to diagnosis. Aim was to study drug utilization pattern of antihypertensive medication in a tertiary care hospital, Telangana.Methods: A cross sectional observational study was done in the patients with hypertension for duration of one year i.e. from April 2017 to May 2018 in the department of Pharmacology at Mallareddy Narayana multispecialty hospital, suraram, Telangana. A total 130 Patients who were suffering with acute, chronic hypertension and admitted in general medicine department and undergoing antihypertensive treatment were included.Results: A Total of 130 patients with history of hypertension were included. majority of patients i.e., 46.1% (60/130) were among 51-60 years, followed by 24.6% (32/130) patients among 41-50 years., Male predominance 80/130 61.5%) compared to females 50/130 (38.4%). In the Present study, 105(80.7%) prescriptions had Monotherapy prescription and 25/130 (19.2%) has combination of two. The most frequently prescribed drug as monotherapy was Calcium Channel Blockers (CCBs) about 52.3%, Beta blockers constitute about 14.2%, and diuretics about 19%, 9.5% Angiotension Receptor Blockers (ARBs) and alpha-Adrenergic Blocker (AABs), 4.7% ACE inhibitors.Conclusions: Calcium channel blockers are the highest among the drugs that are used as monotherapy. In combination therapy, diuretic with angiotensin receptor blocker and calcium channel blocker with beta blocker are the frequently prescribed drugs.

Download Full-text

A STUDY ON DRUG UTILIZATION EVALUATION AND POTENTIAL DRUG RELATED PROBLEMS IN TYPE-2 DIABETES MELLITUS PATIENTS WITH CO-MORBIDITIES IN A TERTIARY CARE HOSPITAL

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2021v13i3.39425 ◽

2021 ◽

pp. 42-46

Author(s):

PRUDENCE A. RODRIGUES ◽

DAWN TESLIN DAMIEN ◽

MARY CECIL K. T. ◽

NARESH KUMAR M. ◽

RESHMA S. S. ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cost Analysis ◽

Drug Utilization ◽

Tertiary Care Hospital ◽

Tertiary Care ◽

Care Hospital ◽

Drug Related Problems

Objective: The objective of this study is to evaluate prescribing pattern, analyze drug-related problems, identify co-morbidities and complications in Type 2 Diabetes Mellitus patients and also to perform cost analysis of Biguanides, Sulfonylureas, Dipeptidyl Peptidase Inhibitors Methods: A Prospective observational study was done in General Medicine and Endocrinology Departments of PSG Hospitals. A total of 200 study subjects, including both inpatients and outpatients, above 18 y of age, prescribed with OHAs (Biguanides, Sulfonylureas and DPP4 inhibitors) were included in the study. Results: Diabetes was more prevalent among males. OHAs were most prescribed in the age group of 51-60 y. Hypertension (71%) was the most common comorbidity and Diabetic neuropathy (23%) was the most common complication found in the patients. Multidrug therapy (72.5%) was most prescribed in diabetic patients, followed by Biguanides. Hypoglycemia was the most prevalent ADR. Cost analysis showed that T. Linagliptin was of high cost and T. Glimepiride being the low cost. Using WHO core indicators prescribing patterns were assessed. Feedback was collected and results were reported to the physicians which showed rational utilization of drugs. Conclusion: The study on drug utilization conducted in a tertiary care hospital helped us to find out that prescribing trends seems to be progressing towards combination therapy, predominantly two-drug therapy

Download Full-text