Effect of sleep quality on educational performance of paramedic students of Prince Sultan Military College of Health Sciences (PSMCHS) in the Eastern Province of Kingdom of Saudi Arabia (KSA)

Increasing students’ academic stress especially during exams may result in sleep disorders, fatigue, poor academic performance and low functional efficiency. The aim of this research is to investigate the effect of sleep quality on educational performance of paramedic students. This research depends on a cross-sectional observational study. The samples of the study were 150 individual who will be chosen randomly from Saudi PSMCHS-Dhahran paramedic students. Data related to demographic aspects, work-related information was gathered from the samples of the study. Finally, the data of the study was analyzed through SPSS program. Four sleep scales were adopted for the study like Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISI), Fatigue Severity Scale (FSS) and Kessler Psychological Distress Scale (KPDS). The level of education like diploma and bachelor had a significant relation between the ESS and FSS. Bridging level of education has relation with KPDS. Marital status and BMI were significant with ISI and KPDS respectively. Physiological distress and excessive day time sleepiness were significant with ISI, FSS and KPDS.It can be stated that sleep quality of paramedic students is affected with high ratio by the educational performance. This is because the high stress of work regarding paramedic students leads them to have less amount of sleep quality and then this affects their educational performance.

Topical application of Apremilast in the treatment of mild to moderate psoriasis

Mild to moderate psoriasis is highly prevalent in about 80% of the global psoriatic population. Current available treatment options for mild to moderate psoriasis are topical dosage forms and are associated variety of setbacks. To address these setbacks, Apremilast topical gels, 2% & 4%, w/w were developed, and a clinical proof of concept study (POC) was performed to establish efficacy and safety. A single centre randomized, double-blind, placebo-controlled study was conducted with apremilast topical gels 2% & 4% w/w in adult mild to moderate psoriatic patients for 12 weeks. The efficacy of the gels was evaluated by comparing the PASI scores before and after treatment of 12 weeks. Both gels exhibited a significant reduction in PASI values when compared with baseline PASI scores. An average percentage inhibition of PASI with test products, i.e. 2% and 4% w/w Apremilast topical gels, are about 46.8% and 34.6%, respectively, after 12 weeks of treatment. The results confirm that the apremilast topical gels are a good option for the treatment of mild to moderate psoriasis and have to be explored further.

The readiness of teachers in primary schools to deal with cardiac arrest situation

Progress in deciding the opinion of head-teachers on the instructional and logistical characteristics needed for a fundamental cardiopulmonary resuscitation (b-CPR) program for adolescents in secondary school. The purpose of the thesis is to explore the level of educators' preparation to cope with life-threatening circumstances. This paper aims to determine the connection between the score of the instructor to the questions drawn up and their knowledge of BSL. And we have studied the participants' student conduct without any impact on their behaviour. Teachers from chosen primary schools are the partners. There will also be a record of population characteristics. There will be registered personal data and documents. Some of the information involves the compilation of gender, gender, degree of education and weight data using survey questions. A high degree of secrecy would be ensured through this study. In addition, all information from the participants will be collected voluntarily. The educators would be allowed to have an answer to all the questions. The primary aim of the research is to raise awareness of the importance of critical support for life in schools. At the beginning of each academic year, this study is proposed to create a compulsory training session for teachers, and the outcome is gathered using survey questions to produce using personal information and data such as sex, gender, level of education and weight details.

Novel drug delivery system of Lycopene: Preparation and in-vitro investigation

Compared to pharmaceutical drugs, herbal medications have known to be more affordable and better for the treatment of many diseases but are less effective and not targeted. Therefore, the use of innovative drug delivery devices to distribute herbal drugs is very helpful in enhancing their release, potency and operation. Lycopene was introduced into the muco-adhesive microspheres. Using sodium alginate, carbopol 934, and sodium CMCC, mucoadhesive microspheres were prepared (carboxy methyl cellulose). The prepared microspheres had been evaluated for its physical and physicochemical parameters, invitro release. The prepared microspheres showed consistent physicochemical parameters, release sustained to 8hrs. Herbal drugs can preferably be delivered using novel drug delivery systems after proper chemical and biological standardization.

Identification and evaluation of osteoporosis diseases using X-Ray scan images

This study aims to inaugurate the comparison among entire hip bone mineral density (RMD) by dual-energy X-ray absorptiometry (DEXA) and a humble clavicle radiogrammetry complete from the ribcage radiograph that provides the result of extraordinary sensitivity and specificity for forecasting full hip BMD from ribcage radiograph for assessment of osteoporosis. Clavicle Radiogrammetry is a method to measure morphometric dimensions like the other and inner diameter of the clavicle at its mid-shaft. Form these measurements; the following Bone Mass Indices are to be calculated, such as the cortical thickness and the Relative thickness. The Clavicle bone is separated from the digital chest X-ray. The Clavicle bone is identified and separated using Active Shape Model algorithm. After this, the morphometric measurements are done. The outcome of the study is whether the digitized chest X-ray analyzed is helpful in the evaluation of osteoporosis or not.

High throughput virtual screening of cyclooxygenase-2 by using database

COX-2 is a type of Non-steroidal mitigating drug (NSAID) that legitimately targets COX-2, a protein liable for irritation and torment. Selectivity for COX-2 decreases the danger of peptic ulceration and is the fundamental component of celecoxib, rofecoxib and different individuals from this medication class. COX-2 selectivity doesn't appear to influence other antagonistic impacts of NSAIDs (most prominently an expanded danger of renal disappointment), and a few outcomes have excited the doubt that there may be an expansion in danger for cardiovascular failure, apoplexy and stroke by a relative increment in thromboxane. The target of this investigation is to screen drug-like compounds from Zinc database and to predict the potency and activity by using Virtual Screening and Molecular Docking Study. The scope of the study extends to predict the feasibility of the compounds for Drug development. Hence, this examination expresses the significance of little particle libraries and their utilization to upgrade drug revelation measure earlier amalgamation. This way to deal with screen original mixes as COX-2 inhibitors from ZINC information base relies upon different boundaries, for example, Lipinski's standard of 5, pharmacophoric bunches appended on the ligand, size of the dataset and compound libraries among others. Additional, exertion can be stretched out to consider the receptor-ligand associations tentatively, and assessment of their organic action would help in planning mixes dependent on simulated screening strategies.

An interventional study to assess the quality of life in abnormal uterine bleeding in a medical college teaching hospital

Abnormal uterine bleeding has a major impact on a woman's quality of life. This study aimed to improve quality of life rather than focusing on the amount of blood loss and also to understand how it affects their quality of life. Patients demographic and therapeutic details were collected (name, age, sex . 80 patients suffering from abnormal uterine bleeding are taken from medical college teaching hospital. The quality of life in patients with abnormal uterine bleeding is assessed using SF 36 . Then up is done for quality of life in patients with abnormal uterine bleeding using SF 36 . This study showed that before counseling the age group of 51-60 years have less physical functioning when compare to other groups and BMI of 0<18.5 have more improvement is seen in physical functioning after . The age group of 21-30 years has less limitation due physical functioning when compare to other groups. Before the age group of 21-30 years felt more pain, was decreased after . Regarding the Quality of life, the impact of AUB encompasses all aspects of QOL with eight health domains measured by SF-36 result shows 32% of the patients quality of life is poorest. Provided to the patients proved to be beneficial in improving their health related QOL. This leads to a conclusion that the public as well as need to increase awareness of the impact of this common benign gynecologic disorder.

A Multicentric non-interventional observational study to determine treatment patterns and response of drugs in various stages of breast cancer along with epidemiology

Cancer is a life-threatening disease which causes to lose cohesiveness and orderliness of normal tissue. These malignant cells can spread to any other organ through blood flow or lymphatic flow and develop malignancy over there; this phenomenon is called metastasis. The aim is to focus on treatment pattern and response of drugs in various stages of breast cancer along with epidemiology. It is a non- interventional multicentric observational study. Female patients confirmed with Breast cancer are included in the study. All the relevant data were collected on a patient demographic form after obtaining informed consent from individual patients. In our study, the mean age of presentation in breast cancer patients was 41.35 years. Further it was found that 40.5% (n = 81) majority-female patients with Breast cancer are from Guntur District and 21.5% (n= 43). The majority of women with Breast cancer have hormone receptor expression of ER+/PR+HER2- was found to be 33% (n= 50). In the study on analyzing comorbidities of the study population, it was noted that 28.5% of women were affected with Diabetes mellitus. In our study, it was found that most of the patients with Breast cancer have been most often prescribed with Adriamycin 27.86%. From these observations, we conclude that late menarche may be one of the etiological causes of breast cancer in women, Invasive carcinoma in situ is the most commonly reported breast cancer in the study. Patients have been diagnosed with breast cancer at their stage 3 of progression, which may be the reason for making it mandatory for more than 50% of patients to undergo 6 to 8 cycles of chemotherapy. Coming to the patterns of drug use, ADRIAMYCIN, CYCLOPHOSPHAMIDE and DOCETAXEL are the three most commonly used single drug and combinational drug therapies among the study population.

Clinical pharmacist interventions in post stroke follow up patients in tertiary care hospital on coastal region

Stroke is basically a medical condition where there is low blood flow to the brain and thus results in cell death. It remains the second most common cause of death. Stroke patients also have different comorbidities on an average where they are prescribed with 6-10 medicines. This increase the chances for drug-related problems (DRPs) and adverse drug events (ADEs) or adverse drug reactions (ADRs) and the interventions found during the follow up of stroke patients. Several studies finding of interventions in stroke patients and reconciliation are ways to reduce ADRs and improve medication use safety. Interventions and medical reconciliation (MR) address a wide array of potential medication-related issues, which is carefully planned that may be done by pharmacist or doctor or professional (or) physician. Here the aim was to access the impact of interventions which includes medications reconciliation and counselling of stroke patients and also identification and categorization of DRPs. Polypharmacy causing DRPs was statistically significant in all the regions inappropriate drug selection (2.85%), and dose selection (2.85%) was the primary cause of DRPs 85% partially solved. Epidemiologically of all the three regions (GNT, VIJ, RJY) in the total study population. Males are more affected than females. Majority of comorbidities like HTN(70.05%), and DM(47.01%)were in leading role causing stroke absorbed during interventions. Leaflet & patient counselling had prominent role in conducting medical reconciliation. Other health care professionals systematically find, differentiate & report interventions like (DRPs, ADRs, and causes).

Pharmacoeconomic evaluation of chronic kidney disease patients: a study on cost of illness

Chronic kidney diseases (CKD) is an important public health problem due to its high prevalence , morbidity and mortality. It is associated with high expenditure among indian patients. Higher stages of CKD have higher economic burden especially on the lower middle class. Hemodialysis, patients habits like alcohol consumption and smoking, treatment support by employer and patients with co morbid conditions and ESRD was found to effect the direct cost of the treatment.. Although CKD is generally Progressive and irreversible patients are advised regarding nutrition, life style changes and compliance with treatment might slow progression, enabling patients to live longer without complication and need for renal replacement therapy. Major barrier in the successful treatment of CKD is high cost of hemodialysis and medication which is difficult for the patient to afford. The main objective is to analyse the direct cost involved in treating Chronic Kidney disease patients in tertiary care hospital. Reimbursement, patients dialysis , social habits and comorbid conditions were found to have a significant effect on the direct cost of treatment.