Impact of hydroxy propyl methyl cellulose on drug release profile and drug release kinetics of Moringa extract formulated as granules

The aim of present work is to determine and analyse the kinetics of drug release from the fast dissolving sublingual by employing various mathematical models. A study was done with Cyanocobalamine fast dissolving sublingual films, 1.5 mg/film by employing solvent casting technique using dehydrated banana starch and Gelatin. The in-vitro drug release profile was carried out in pH 6.8 phosphate buffer (900 mL) using USP dissolution apparatus I (Basket) at 50 rpm for 20 mins. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model, Hixson-Crowell model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug release profile of Cyanocobalamine fast dissolving sublingual films.

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Hydrogel-Forming Microneedle Arrays for Sustained and Controlled Ocular Drug Delivery

Journal of Engineering and Science in Medical Diagnostics and Therapy ◽

10.1115/1.4048481 ◽

2020 ◽

Vol 3 (4) ◽

Author(s):

Maher Amer ◽

Roland K. Chen

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Release Kinetics ◽

Therapeutic Index ◽

Ocular Drug Delivery ◽

Release Profile ◽

Drug Release Profile ◽

Sustained Drug Release ◽

Sustained Drug Delivery ◽

Kinetics Of

Abstract Microneedles (MNs) provide a minimally invasive alternative to intravitreal injections and a promising means to sustainable ocular drug delivery. To optimize the sustained drug release profile and to ease the administration of the MN array to the eye, the number of MNs in an MN array and their layout need to be carefully selected. In this study, the drug release kinetics of MN arrays with varying numbers of MNs (8, 12, and 16) is studied over a four-week period. The MN arrays show a much more uniform drug release profile than the single injections. Only the 16-needle MN array fully released all the amount of loaded drug at the end of the 4-week period. Both 8- and 12-needle arrays showed a steady release rate over the 4-week period, which is the longest sustained release duration that has been reported. Zero-order models are created to predict drug release profiles for the three MN arrays. It is estimated that the MN array with 8 needles can deliver the drug for up to 6 weeks. The models can be used to design MN arrays with a given targeted therapeutic index for sustained drug delivery.

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Formulation and Evaluation of Floating and Mucoadhesive tablets containing Glipizide

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v11i1.1912 ◽

2020 ◽

Vol 11 (1) ◽

pp. 899-907

Author(s):

Jagdish K Arun ◽

Dharmajit Pattanayak ◽

Shrivastava B ◽

Ramesh Adepu

Keyword(s):

Drug Release ◽

Release Kinetics ◽

Evaluation Studies ◽

Methyl Cellulose ◽

Release Profile ◽

In Vivo Study ◽

Drug Release Profile ◽

Compression Technique ◽

Mucoadhesive Tablets

In the present study, Glipizide, a drug mainly preferred for type-II diabetes, is formulated in the form of floating mucoadhesive tablets to improve its bioavailability. Hydroxy Propyl Methyl Cellulose K200M, Sodium Carboxy Methyl Cellulose, Carbopol 974P, Karaya gum, Chitosan, and Xanthan gum were used as mucoadhesive polymers in designing of the floating mucoadhesive tablets. Different proportions of glipizide and polymer were used to prepare tablets. Pre-compression evaluation studies evaluated the powder blend of Glipizide mucoadhesive tablets (Pre-compression blend). It concluded that the blend had good flow property and better compressibility by interpreting the data obtained from the test. Hence the floating mucoadhesive tablets were prepared by direct compression technique. The results of floating lag time, and buoyancy studies suggested that formulations had a satisfactory floating ability. The release profile of the active pharmaceutical ingredient (glipizide) from the prepared dosage form indicated a controlled and enhanced drug release for a period of 12hrs. An in-vivo study done for selected formulation. By the interpretation of data obtained from all the evaluation studies (Pre-compression test, floating property, drug release profile, & in-vivo study) concluded that formulation GF8 containing drug: Carbopol 974P (1:2) was optimized. The drug release kinetics of the formulation GF8 followed the Higuchi model with a regression value of 0.993.

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