A clean, simple and efficient synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2-h] quinolin-2-yl]-(4-chlorophenyl)methanones
Keyword(s):
We report a green and efficient method for the synthesis of trans-[3-(aryl)-2,3-dihydrofuro[3,2- h]quinolin-2-yl]-(4-chlorophenyl) methanones from the condensation of 2-[2-(4-chlorophenyl)-2-oxoethyl)]isoquinolinium bromide with 8-hydroxyquinoline and an aromatic aldehyde in the presence of catalytic amounts of choline hydroxide in water at reflux conditions. This new protocol employing choline hydroxide, which is a green and inexpensive catalyst, offers advantages such as mild reaction conditions, short reaction time, high yields and does not involve any hazardous solvent. Therefore, this procedure can be classified as green chemistry.
2009 ◽
Vol 2009
(10)
◽
pp. 638-641
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2019 ◽
Keyword(s):
PhI(OAc)2-Mediated One-Pot Synthesis of Benzoxazinones from Anthranilic Acids and Aromatic Aldehydes
2012 ◽
Vol 36
(3)
◽
pp. 123-126
◽
Keyword(s):
One Pot
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