Characteristics of the Comprehension of Active and Passive Sentences in Patients with Nonfluent Aphasia

2021 ◽  
Vol 37 (4) ◽  
pp. 125-144
Author(s):  
Jungyeon Kim
Keyword(s):  
Nonfluent Aphasia

Frontotemporal Lobar Degeneration: Characterizing Semantic Binding and Abstracted Meaning Abilities

2009 ◽  
Vol 19 (4) ◽  
pp. 117-125 ◽  
Author(s):  
Raksha Anand ◽  
John Hart ◽  
Patricia S. Moore ◽  
Sandra B. Chapman
Keyword(s):  
Frontotemporal Lobar Degeneration ◽  
Assessment Tools ◽  
Progressive Decline ◽  
Cognitively Normal ◽  
Nonfluent Aphasia ◽  
Traditional Assessment ◽  
Language Measures ◽  
Semantic Object ◽  
Semantic Problem ◽  
Progressive Nonfluent Aphasia

Abstract Purpose: Frontotemporal lobar degeneration (FTLD) encompasses a group of neurodegenerative disorders characterized by gradual and progressive decline in behavior and/or language. Identifying the subtypes of FTLD can be challenging with traditional assessment tools. Growing empirical evidence suggests that language measures might be useful in differentiating FTLD subtypes. Method: In this paper, we examined the performance of five individuals with FTLD (two with frontotemporal dementia, two with semantic dementia, and one with progressive nonfluent aphasia) and 10 cognitively normal older adults on measures of semantic binding (Semantic Object Retrieval Test and semantic problem solving) and abstracted meaning (generation of interpretive statement and proverb interpretation). Results and Conclusion: A differential profile of impairment was observed in the three FTLD subtypes on these four measures. Further examination of these measures in larger groups will establish their clinical utility in differentiating the FTLD subtypes.

Autosomal Dominant Frontotemporal Lobar Degeneration in a Filipino Family with Progranulin Mutation

2021 ◽  
pp. 1-8
Author(s):  
Jacqueline Dominguez ◽  
Arlene Ng ◽  
Jeryl Yu ◽  
Anne Cristine Guevarra ◽  
Maria Luisa Daroy ◽  
...  
Keyword(s):  
Frontotemporal Lobar Degeneration ◽  
White Matter Hyperintensities ◽  
Autosomal Dominant ◽  
The Philippines ◽  
Vascular Risk ◽  
Case Presentation ◽  
Nonfluent Aphasia ◽  
Protein Tau ◽  
Review Reports ◽  
Progressive Nonfluent Aphasia

<b><i>Background:</i></b> Compared to Western populations, familial frontotemporal lobar degeneration (FTLD) is rare among Asians. Progranulin (GRN) gene mutation, which is a major cause of FTLD, is likewise rare. We present a family with FTLD from the Philippines with an autosomal dominant pattern of inheritance and GRN mutation and briefly review reports of GRN mutations in Asia. <b><i>Case Presentation:</i></b> The proband is 66 years old with progressive nonfluent aphasia (PNFA)-corticobasal syndrome . We assessed 3 generations of her pedigree and found 11 affected relatives with heterogenous phenotypes, usually behavioral variant frontotemporal dementia (FTD) and PNFA. Neuroimaging showed atrophy and hypometabolism consistent with FTD syndromes. White matter hyperintensities were seen in affected members even in the absence of vascular risk factors. A GRN mutation R110X was found in 6 members, 3 with symptoms and 3 were asymptomatic. Plasma GRN was low (&#x3c;112 ng/mL) in all mutation carriers. No mutations were found in microtubule-associated protein tau, APP, PSEN1, and PSEN2 genes, and all were APOE3. <b><i>Conclusion:</i></b> This is the first Filipino family with autosomal dominant FTD documented with GRN mutation. Identifying families and cohorts would contribute to therapeutic developments in an area with FTD-GRN.

Recovery from nonfluent aphasia after melodic intonation therapy: A PET study

Neurology ◽  
1996 ◽  
Vol 47 (6) ◽  
pp. 1504-1511 ◽  
Author(s):  
P. Belin ◽  
M. Zilbovicius ◽  
Ph. Remy ◽  
C. Francois ◽  
S. Guillaume ◽  
...  
Keyword(s):  
Nonfluent Aphasia ◽  
Melodic Intonation Therapy

Nonfluent aphasia after closed head trauma: Report of a case

1999 ◽  
Vol 57 (6) ◽  
pp. 745-748 ◽  
Author(s):  
Mark Stein ◽  
Stephen B Cantrell
Keyword(s):  
Head Trauma ◽  
Nonfluent Aphasia ◽  
Closed Head ◽  
Closed Head Trauma

Psychosocial changes and psychosocial adjustment with chronic and severe nonfluent aphasia

Aphasiology ◽  
1989 ◽  
Vol 3 (6) ◽  
pp. 513-526 ◽  
Author(s):  
Manfred Herrmann ◽  
Claus-W. Wallesch
Keyword(s):  
Psychosocial Adjustment ◽  
Nonfluent Aphasia

Syntax Stimulation Revisited

1995 ◽  
Vol 4 (4) ◽  
pp. 99-104 ◽  
Author(s):  
Ruth B. Fink ◽  
Myrna F. Schwartz ◽  
Elizabeth Rochon ◽  
Jessica L. Myers ◽  
Gail Simon Socolof ◽  
...  
Keyword(s):  
Multiple Baseline ◽  
Structure Modeling ◽  
The Novel ◽  
Connected Speech ◽  
Language Program ◽  
Nonfluent Aphasia ◽  
Coding Scheme ◽  
Narrative Production ◽  
Before And After ◽  
Picture Description

A multiple-probes variant of the multiple-baseline across-behaviors design was used to study the extent of generalization associated with syntax stimulation (SS) training. To assess whether acquisition of specific structures generalized across tasks, we used a specially designed sentence elicitation probe, Picture Description with Structure Modeling (PDSM; Fink et al., 1994). To assess whether training enhanced morphosyntactic production in connected speech, we used the coding scheme developed by Saffran, Berndt, and Schwartz (1989). Four subjects with chronic nonfluent aphasia were trained to produce active, passive, and embedded sentences using materials and procedures from the Helm Elicited Language Program for Syntax Stimulation (Helm-Estabrooks, 1981). These sentence structures were trained in successive phases with generalization probes administered before and after each phase. Three subjects with aphasia served as controls. Strong within-task generalization was observed and, in contrast to previous studies, generalization to the novel sentence elicitation task (PDSM). SS training did not yield measurable gains in narrative production.

Providing Augmentative and Alternative Communication Treatment to Persons With Progressive Nonfluent Aphasia

2010 ◽  
Vol 20 (1) ◽  
pp. 21-25 ◽  
Author(s):  
Melanie Fried-Oken ◽  
Charity Rowland ◽  
Chris Gibbons
Keyword(s):  
Augmentative And Alternative Communication ◽  
Clinical Implications ◽  
Disease Course ◽  
Alternative Communication ◽  
Future Directions ◽  
Verbal Expression ◽  
Nonfluent Aphasia ◽  
Oregon Health ◽  
And Training ◽  
Progressive Nonfluent Aphasia

Abstract Augmentative and alternative communication (AAC) intervention offers people diagnosed with progressive nonfluent aphasia (PNFA) an opportunity to continue to communicate even as verbal expression declines. To date, there are no well-controlled studies reporting the effectiveness of AAC intervention with people who present with PNFA. Further, there is a pressing need for evidence about specific AAC intervention tools, techniques, and training protocols for persons with PNFA and their communication partners. We have engaged in research studies at the Oregon Health & Science University to quantify low-tech AAC supports for people with PNFA in highly controlled, as well as naturalistic, dyadic conversations. Preliminary results suggest that AAC provides strong lexical support for people with PNFA during conversation. We predict that training participants and their partners how to use personalized, low-tech communication boards will lead to reduced conversational scaffolding by partners and prolonged effective communication as the disease course progresses. Clinical implications and future directions of our research are discussed.

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