Dementia prevention and reserve against neurodegenerative disease

2019 ◽  
Vol 21 (1) ◽  
pp. 53-60

Similar to other complex disorders, the etiology of Alzheimer disease is multifactorial and characterized by an interplay of biological and environmental risk and protective factors. Potentially modifiable risk factors have emerged from epidemiological research and strategies to prevent neurodegeneration and dementia are currently being tested, including multimodal interventions aiming to reduce several risk factors at once. The concept of reserve was developed based on the observation that certain individual characteristics, such as life experiences, lifestyles, and neurobiological parameters, are associated with a higher resilience against neurodegeneration and its symptoms. Coordinated research is required to maximize the use of available human and financial resources to better understand the underlying neurobiological mechanisms of reserve and to translate research findings into effective public health interventions.

2019 ◽  
Vol 21 (1) ◽  
pp. 53-60 ◽  

Similar to other complex disorders, the etiology of Alzheimer disease is multifactorial and characterized by an interplay of biological and environmental risk and protective factors. Potentially modifiable risk factors have emerged from epidemiological research and strategies to prevent neurodegeneration and dementia are currently being tested, including multimodal interventions aiming to reduce several risk factors at once. The concept of reserve was developed based on the observation that certain individual characteristics, such as life experiences, lifestyles, and neurobiological parameters, are associated with a higher resilience against neurodegeneration and its symptoms. Coordinated research is required to maximize the use of available human and financial resources to better understand the underlying neurobiological mechanisms of reserve and to translate research findings into effective public health interventions.


2019 ◽  
Vol 21 (1) ◽  
pp. 53-60 ◽  

Similar to other complex disorders, the etiology of Alzheimer disease is multifactorial and characterized by an interplay of biological and environmental risk and protective factors. Potentially modifiable risk factors have emerged from epidemiological research and strategies to prevent neurodegeneration and dementia are currently being tested, including multimodal interventions aiming to reduce several risk factors at once. The concept of reserve was developed based on the observation that certain individual characteristics, such as life experiences, lifestyles, and neurobiological parameters, are associated with a higher resilience against neurodegeneration and its symptoms. Coordinated research is required to maximize the use of available human and financial resources to better understand the underlying neurobiological mechanisms of reserve and to translate research findings into effective public health interventions.


2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
D Mangaloiu ◽  
E Bratu ◽  
F Furtunescu ◽  
D Minca

Abstract Background Knowing the prevalence of modifiable risk factors for noncommunicable diseases is the first step to plan effective public health interventions. The study aims to identify the prevalence and distribution of risk factors of non-communicable diseases (NCD) among adult Roma population in a rural community. Methods Using a tool based on the WHO stepwise approach, a cross-sectional study was carried out among a sample 116 adults aged 18-85 years (52 male and 64 female), from a rural community with 800 Roma members. The study instrument included questions to record behavioral risk factors (smoking behavior, alcohol drinking, diet and physical activity and also data on anthropometry and value of blood pressure). Descriptive statistics methods were used to analyze the data. Results The smoking prevalence was 35,3% (95%CI, 27.0 to 44.3,) higher for men (49,9%, 95%CI, 36,6-63,4%) than for women (23,4%, 95%CI, 14.2-34,9), higher than the smoking prevalence recorded for Romanian population in 2017 Eurobarometer study. Prevalence of obesity (body mass index ≥30 kg/m[2]) was observed to be high among Roma respondents 34,48% (95% CI, 26,26 to 43,47) compared with self-reported obesity rates among adults in Romania (9%, Eurostat, EHIS 2014). The observed proportion of obesity is similar for both genders, but central obesity was lower for men compared to women (57,4% to 79.6%). There was observed a higher proportion of people declaring they eat fruits less than once on a week (25%, 95% CI, 17,7 to 37,4) and adding salt before tasting the dishes (58,6%). Most of interviewed people have a sedentary lifestyle with less than 30 minutes of physical activity per day. Conclusions The high prevalence of risk factors for NCD in this rural Roma community indicates the likelihood of a high future burden of illness. Key messages There is a need for both further research into the health of Roma people regarding NCD and prevention interventions to address behavioral risk factors for NCD. Knowing the prevalence of modifiable risk factors for noncommunicable diseases is the first step to plan effective public health interventions.


2015 ◽  
Vol 23 (3) ◽  
pp. 644-648 ◽  
Author(s):  
Hopin Lee ◽  
James H McAuley ◽  
Markus Hübscher ◽  
Heidi G Allen ◽  
Steven J Kamper ◽  
...  

Background Back pain is a global health problem. Recent research has shown that risk factors that are proximal to the onset of back pain might be important targets for preventive interventions. Rapid communication through social media might be useful for delivering timely interventions that target proximal risk factors. Identifying individuals who are likely to discuss back pain on Twitter could provide useful information to guide online interventions. Methods We used a case-crossover study design for a sample of 742 028 tweets about back pain to quantify the risks associated with a new tweet about back pain. Results The odds of tweeting about back pain just after tweeting about selected physical, psychological, and general health factors were 1.83 (95% confidence interval [CI], 1.80-1.85), 1.85 (95% CI: 1.83-1.88), and 1.29 (95% CI, 1.27-1.30), respectively. Conclusion These findings give directions for future research that could use social media for innovative public health interventions.


2015 ◽  
Vol 6 (3) ◽  
pp. 99-124
Author(s):  
Ishu Kataria ◽  
Ravinder Chadha ◽  
Renuka Pathak

Metabolic syndrome is a constellation of risk factors that has the potential of developing into cardiovascular disease or increase the susceptibility to it. It is present worldwide with now even developing countries getting overwhelmed by its burden. With a shift towards unhealthy diet coupled with sedentary lifestyle, development of metabolic syndrome is on the rise even among young adults. One of the main causes of this problem is faulty diet, so any means to reduce the incidence of the syndrome involves the modification of the existing diets rich in saturated fat, sodium and cholesterol. This review focusses on efficacy of different dietary patterns for combating the syndrome along with other lifestyle risk factors. It also highlights newer advancements in the field of Metabolic Syndrome, which can serve as potential strategies to combat it. Public health interventions targeting adults, therefore, should center on prevention through education, modification of diet and lifestyle, and focusing on environment, so that these changes are acceptable and sustainable.


2018 ◽  
Vol 13 (2) ◽  
Author(s):  
Shamoon Noushad ◽  
Shershah Syed ◽  
Sadaf Ahmed

Aims: To explore the impact of obstetric fistula in the county and to propose effective public health interventions that can help to prevent the condition with a long-term goal of eradicating the condition. Methods: The survey and analysis included secondary data addressing women's experiences of fistula; dynamics and limitationsdetermining women's access to in healthcare facilities for fistula management; and restraintsof health professional as well as health inequities. Results: It was assessed that recently, many hospitals and organizations in the country go on board on intercessions to address the impact of the illness, however, much importance is on pinpointing and discussing the existing cases rather than focusing on public health interventions that can help to prevent and eventually eradicate the condition in Pakistan.


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