scholarly journals Adding stewed apricot juice to sena improves the right-side and overall colon cleansing quality for colonoscopy preparation

2017 ◽  
Vol 7 (1) ◽  
pp. 54
Author(s):  
Bulent Yasar ◽  
Evren Abut ◽  
Huseyin Kayadibi ◽  
Fatih Akdoğan ◽  
Can Gonen
Keyword(s):  
Adverse Events ◽  
Patient Comfort ◽  
Patient Acceptance ◽  
Colonoscopic Examination ◽  
Colon Cleansing ◽  
Patient Tolerance ◽  
Bowel Cleansing ◽  
The Right ◽  
Colonoscopy Preparation

Background: To achieve optimal colonoscopic examination, the bowel must be sufficiently cleansed. However, none of the currently available colonoscopy preparation regimens is safe, efficient and comfortable. The aim of this study was to determine whether adding stewed apricot juice to senna increased patient comfort and improved bowel cleansing during colonoscopy preparation.Methods: Outpatients of both genders, aged over 18 years, who were referred for elective colonoscopy were randomly allocated to drink stewed apricot juice with senna or senna alone. The quality of colon cleansing was evaluated using the Ottawa scale. The evaluation of patient tolerance and adverse events was made through completion of a questionnaire. Results: The study included a total of 128 patients in the randomization procedure. A significantly greater effect of cleansing  was determined with stewed apricot juice plus senna in the right and transverse colon (p= 0.038, p=0.037, respectively). It was also determined that in the stewed apricot juice plus senna group, overall cleansing was superior (p<0.001), total colonoscopy (17.6 min vs 22.8 min, p=0.048) and cecal intubation (7.4 min vs 11.2 min, p=0.042) times were shorter, and the colonoscopy procedure was easier (79.4%vs 49.2%, p<0.001). No difference was determined between the groups in respect of patient  acceptance, compliance and adverse events (p>0.05). In the stewed apricot juice plus senna group, 91.2% of patients stated willingness to receive the same regimen in the future compared with 80% of the patients in thesenna alone group (p=0.037).Conclusion: The addition of natural, stewed apricot juice to senna significantly improves cleansing outcomes without additional adverse events.Keywords: bowel cleansing, colonoscopy, stewed apricot juice, senna.

scholarly journals Efficacy and safety of a ready-to-drink bowel preparation for colonoscopy: a randomized, controlled, non-inferiority trial

2019 ◽  
Vol 12 ◽  
pp. 175628481985151 ◽  
Author(s):  
Lawrence Hookey ◽  
Gerald Bertiger ◽  
Kenneth Lee Johnson ◽  
Julia Ayala ◽  
Yodit Seifu ◽  
...  
Keyword(s):  
Adverse Events ◽  
Bowel Preparation ◽  
Oral Solution ◽  
Right Colon ◽  
Split Dose ◽  
Colon Cleansing ◽  
Randomized Controlled ◽  
Secondary Efficacy Endpoint ◽  
Sodium Picosulfate ◽  
The Right

Background: We performed a randomized, controlled, assessor-blinded, multicenter, non-inferiority (NI) study to compare the safety and efficacy of a ready-to-drink formulation of sodium picosulfate, magnesium oxide, and citric acid (SPMC oral solution) with a powder formulation (P/MC powder) for oral solution. Methods: Eligible participants (adults undergoing elective colonoscopy) were randomized 1:1 to split-dose SPMC oral solution or P/MC powder. The primary efficacy endpoint assessed overall colon-cleansing quality with the Aronchick Scale (AS), and the key secondary efficacy endpoint rated quality of right colon cleansing with the Boston Bowel Preparation Scale (BBPS). Assessments were performed by a treatment-blinded endoscopist. Tolerability was assessed using the Mayo Clinic Bowel Prep Tolerability Questionnaire. Safety assessments included adverse events and laboratory evaluations. Results: The study included 901 participants: 448 for SPMC oral solution; 453 for P/MC powder. SPMC oral solution demonstrated non-inferiority to P/MC powder {87.7% (393/448) responders versus 81.5% (369/453) responders [difference (95% confidence interval): 6.3% (1.8, 10.9)]}. The key secondary efficacy objective assessing the right colon was also met. According to the prespecified hierarchical testing, after meeting the primary and key secondary objectives, SPMC oral solution was tested for superiority to P/MC powder for the primary endpoint ( p = 0.0067). SPMC oral solution was well tolerated. Most common adverse events were nausea (3.1% versus 2.9%), headache (2.7% versus 3.1%), hypermagnesemia (2.0% versus 5.1%), and vomiting (1.3% versus 0.7%) for SPMC oral solution and P/MC powder, respectively. Conclusions: Ready-to-drink SPMC oral solution showed superior efficacy of overall colon cleansing compared with P/MC powder, with similar safety and tolerability. [ClinicalTrials.gov identifier: NCT03017235.]

scholarly journals A Randomized Prospective Study of Bowel Preparation for Colonoscopy with Low-Dose Sodium Phosphate Tablets versus Polyethylene Glycol Electrolyte Solution

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Erina Kumagai ◽  
Tomoyoshi Shibuya ◽  
Masae Makino ◽  
Takashi Murakami ◽  
Shiori Takashima ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Bowel Preparation ◽  
Low Dose ◽  
Patient Acceptance ◽  
Colon Cleansing ◽  
Bowel Cleansing ◽  
Secondary Endpoints ◽  
Tablet Preparation ◽  
Sodium Phosphates ◽  
Improve Patient

Optimal bowel preparation is essential for the safety and outcome of colonoscopy. A solution containing polyethylene glycol (PEG) is often used as a bowel cleansing agent, but some patients are intolerant of PEG, and this may lead to discontinuation of colonoscopy. Sodium phosphates (NaP) tablets are designed to improve patient acceptance and compliance. The objective of this study was to compare bowel preparation efficiency and patient acceptance of a 30 NaP tablet preparation (L-NaP) and a 2 L PEG preparation. Patients were randomized into either the L-NaP or PEG group. The primary endpoint was the efficiency of colon cleansing as assessed by a validated four-point scale according to the Aronchick scale by endoscopists and was verified by blinded investigators. The secondary endpoints were patients’ tolerability and acceptance. Colon-cleansing efficiency was not significantly different between the two preparations. However, patients’ overall judgment was significantly in favor of L-NaP, reflecting better acceptance of L-NaP than PEG. Additionally, more patients favored L-NaP over PEG in a hypothetical future occasion requiring colonoscopy.

Interface pressures with compression systems: relevance to clinical practice

2019 ◽  
Vol 24 (Sup10) ◽  
pp. S32-S35
Author(s):  
Jeanette Muldoon
Keyword(s):  
Clinical Practice ◽  
Clinical Effectiveness ◽  
Patient Comfort ◽  
Patient Acceptance ◽  
Related Factors ◽  
Treatment Regimens ◽  
Correct Application ◽  
The Right ◽  
Instructions For Use ◽  
Interface Pressures

Interface pressures with compression depend on many factors relating to the science of measurement and intrinsic, patient-related factors, including limb size and tissue texture. While it is important for manufacturers of compression devices to measure pressures, it may not always be relevant to clinical practice where application methods and oedematous limbs may affect final pressures. Accurate performance of any compression system relies on the use of the right technology for the right condition and patient lifestyle. Correct application following training and in accordance with instructions for use may be adapted according to individual patient comfort and needs, including mobility, tissue texture and the stage of management. In order to provide treatment regimens that are safe, effective and well tolerated by patients, as well as being easy to apply and demonstrate sound economic practice, science needs to meet clinical practice. Patient reporting is an important for successful treatment, matching clinical effectiveness with patient acceptance during reassessment and monitoring.

scholarly journals An Improved Colonoscopy Preparation Method and its Acceptability by Patients

1995 ◽  
Vol 1 (3) ◽  
pp. 141-145
Author(s):  
Masanori Tsuruoka
Keyword(s):  
Preparation Method ◽  
Magnesium Citrate ◽  
Patient Tolerance ◽  
Colonic Cleansing ◽  
Before And After ◽  
Sodium Picosulfate ◽  
Lukewarm Water ◽  
Colonoscopy Preparation ◽  
Abdominal Fullness

The author presents an improved method of preparation for colonoscopy that involved no dietary limitation on the patient until the day of the examination and that was shown by a randomized questionnaire evaluation to earn good patient tolerance and acceptance. Patients were given 10 mg of cisapride and 75 mg of sodium picosulfate before sleep on the day preceding the examination, and 50 g of magnesium citrate powder (MP) in 1,200 mL lukewarm water before the examination. It was divided into 600-mL portions and ingested slowly during two 30-minute periods. Ninety-five percent of patients classified the taste of a magnesium citrate powder laxative as palatable in the questionnaire given immediately after the procedure. Concerning the quantity, 79.4% replied that it was tolerable, 17.3% considered it somewhat excessive, and 3.3% replied that it was barely tolerable. No patient classified it as intolerable. Symptoms after taking laxatives and lukewarm water such as abdominal pain, nausea and abdominal fullness were observed in 3.8%, 4.4% and 5.6%, respectively, whereas there were no symptoms in 79% of patients. Body weight and serum K level showed a tendency to decrease, whereas the serum Mg level showed an increase before and after colonoscopy. The quality of colonic cleansing evaluated by colonoscopy was excellent, good, or fair in a total of 93.3%. No adverse effects were observed. It was concluded that this method is a clinically beneficial and well-tolerated preparation for colonic examinations.

scholarly journals THE USE OF ENTERAL NUTRITION IN BOWEL CLEANSING BEFORE COLONOSCOPY

2018 ◽  
pp. 25-30
Author(s):  
A. V. Galyaev ◽  
D. A. Mtvralashvili ◽  
O. V. Arkhipova ◽  
V. V. Veselov ◽  
S. S. Belous
Keyword(s):  
Enteral Nutrition ◽  
Subjective Assessment ◽  
Protein Diet ◽  
Diagnostic Colonoscopy ◽  
Colon Cleansing ◽  
Negative Results ◽  
Bowel Cleansing ◽  
Prospective Comparative Study ◽  
Standard Protein

AIM: to evaluate the effectiveness of bowel cleansing before colonoscopy using enteral nutrition agent «Nutridrink» as the single nutrient. MATERIALS AND METHODS: a prospective comparative study included 150 patients (83 females, aged 20-65 years), who underwent diagnostic colonoscopy. To assess the quality of bowel cleansing the Likert scale was used. Subjective assessment of patients' comfort was performed by patients on a 10-point visual scale (from 0 - «excellent» to 10 - «extremely negative»). RESULTS: the quality of colon cleansing before colonoscopy was significantly better in patients who got enteral nutrition, especially in comparison with patients with standard protein diet. Subjective assessment of comfort during cleansing was better in the group of patients who used Nutridrink as the only source of nutrition as well. CONCLUSION: use of enteral nutrition as a part of bowel cleansing before colonoscopy can replace the protein diet.

scholarly journals The Effectiveness, Tolerability, and Safety of Different 1-Day Bowel Preparation Regimens for Pediatric Colonoscopy

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Anna Szaflarska-Popławska ◽  
Dominika Tunowska ◽  
Ola Sobieska-Poszwa ◽  
Anna Gorecka ◽  
Aneta Krogulska
Keyword(s):  
Polyethylene Glycol ◽  
Adverse Events ◽  
Bowel Preparation ◽  
Similar Efficacy ◽  
Serious Adverse Events ◽  
Preparation Methods ◽  
Sodium Picosulphate ◽  
Bowel Cleansing ◽  
Patient Reported ◽  
Colonoscopy Preparation

Background. Currently, there is no generally accepted universal protocol for bowel preparation before colonoscopy in children. Aim. The aim of the study was to compare three different 1-day bowel preparation methods for a pediatric elective colonoscopy in terms of their efficacy, safety, and patient-reported tolerability. Material and Methods. The study was randomized, prospective, and investigator-blinded. All children aged 10 to 18 years consecutively referred to the tertiary pediatric gastroenterology unit were enrolled. The participants were randomized to receive polyethylene glycol 3350 combined with bisacodyl (PEG-bisacodyl group), or polyethylene glycol 4000 with electrolytes (PEG-ELS group), or sodium picosulphate plus magnesium oxide plus citric acid (NaPico+MgCit group). Bowel preparation was assessed according to the Boston Bowel Preparation Scale (BBPS). For patient tolerability and acceptability, questionnaires were obtained. Results. One hundred twenty-three children were allocated to three age- and sex-matched groups. All of the patients completed colonoscopies with visualization of the cecum. There was no difference among the groups for the mean BBPS score. A total of 73 patients (59.3%) experienced minor adverse events. No serious adverse events occurred in any group. Nausea was the only symptom more frequent in the PEG-ELS group compared to the NaPico+MgCit group (p=0.04), and apathy was the only symptom more frequent in PEG-bisacodyl than in the NaPico+MgCit group (p=0.04). All of the patients were able to complete 75% or more of the study protocol, and 85.4% were able to complete the full regimen. The acceptability was the highest in the NaPico+MgCit group with respect to the patient’s grade for palatability, low volume of the solution, and willingness to repeat the same protocol. Conclusion. All bowel cleansing methods show similar efficacy. However, because of the higher tolerability and acceptability profile, the NaPico+MgCit-based regimen appears to be the most proper for colonoscopy preparation in children.

scholarly journals Comparison of Polyethylene Glycol versus Lactulose Oral Solution for Bowel Preparation prior to Colonoscopy

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Chun-Xia Li ◽  
Yan Guo ◽  
Yang-Jie Zhu ◽  
Jian-Ru Zhu ◽  
Qian-Song Xiao ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Bowel Preparation ◽  
Oral Solution ◽  
Physician Satisfaction ◽  
Detection Rates ◽  
Bowel Cleansing ◽  
Degree Of Satisfaction ◽  
Bowel Preparations ◽  
Colonoscopy Preparation

Objective. This study was conducted to compare a lactulose oral solution with a polyethylene glycol (PEG) formulation for colonoscopy preparation using the following metrics: quality of cleansing, colonoscopy outcomes, patient/physician satisfaction, and patient tolerability. Methods. The enrolled patients were randomly divided into two groups and received a single 2 L dose of either PEG (PEG group) or lactulose (Lac group). The Boston Bowel Preparation Scale (BBPS) was used for assessing the cleansing quality of the bowel preparations. Patient tolerability and adverse events were obtained through the completion of questionnaires. Results. The lactulose oral solution showed superior bowel cleansing compared to PEG, as evidenced by higher BBPS scores in the Lac group for all segments of the colon (P<0.05). The detection rates of polyps and intestinal lesions in the Lac group (30.68% and 36.36%, respectively) were significantly higher than those in the PEG group (12.50% vs. 13.63%, respectively). For the degree of satisfaction, the Lac group had significantly higher scores compared to the PEG group, as evaluated by both the patients and endoscopist. PEG was associated with an increased incidence of nausea. There were no statistical differences between the groups in terms of vomiting, abdominal pain or fullness, dizziness, unfavorable palatability, dry mouth, palpitation, tinnitus, and tongue numbness. Conclusion. A single 2 L dose of a lactulose oral solution had higher efficacy, improved tolerability, and acceptable safety for bowel preparation when compared to the same volume of PEG. Thus, a lactulose oral solution may be a potential bowel-cleansing option for colonoscopy preparation.

PP443 Effectiveness And Safety Of Transcatheter Therapy Interventions Devices For Treatment Of Tricuspid Regurgitation

2020 ◽  
Vol 36 (S1) ◽  
pp. 35-36
Author(s):  
Esther Elena Garcia_Carpintero ◽  
Jordi Gol Freixa ◽  
Luis María Sánchez Gómez
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Adverse Events ◽  
Mortality Rates ◽  
Transcatheter Therapy ◽  
Procedural Success ◽  
Therapy Interventions ◽  
The Right

IntroductionTricuspid regurgitation (TR) is defined as incompetence of the tricuspid valve (TV), which produces the movement of blood flow from the right ventricle (RV) to the right atrium during systole. Pathological TR is functional in nearly 80–90 percent of cases, secondary to volume and/or pressure overload in the RV. Surgical intervention of TR is associated with mortality rates of 10 percent. Transcatheter therapy interventions (TTI) can be an alternative for severe TR. The aim of this study is to assess effectiveness and safety of TTI.MethodsA systematic review was carried out. The scientific literature search was performed in major medical databases. Studies analyzing the efficacy and safety of the devices were included. Outcomes related with mortality rates, TR volume reduction, echocardiographic findings and adverse events were analyzed. The methodological quality of the studies was analyzed with the Canadian Institute of Health Economics Quality Appraisal Checklist.ResultsNine studies comprising 557 patients were included (two first-in-human studies, one retrospective, five single arm prospective studies and one international registry). The studies were small with short follow up. The outcome of procedural success ranged from 80 to 100 percent. Mortality rates at 30 days were lower than 5 percent. Improvements in reduction of TR, European System for Cardiac Operative Risk Evaluation (EuroSCORE), heart failure symptoms or quality of life scores were observed in all studies.ConclusionsTTI for moderate-severe TR show significant reduction of annulus dimension, improvements in heart failure symptoms and quality of life, which are maintained in mid-term follow up. TTI present lower rates of major serious adverse events. No differences were observed between different TTI devices in terms of procedural success, mortality or safety. Randomized studies comparing TTI with optimal medical therapy are needed to confirm the preliminary clinical impact in patients with severe TR, and define aspects such as patient selection, risk factors associated with procedural success or mortality rates.

scholarly journals Application of the complex Edelim in pathogenetic management of patients with erectile dysfunction

2021 ◽  
Vol 11 (3) ◽  
pp. 219-225
Author(s):  
Pavel S. Kyzlasov ◽  
Eugeniy V. Volokitin ◽  
Ali T. Mustafayev ◽  
Evgeny V. Pomeshkin
Keyword(s):  
Blood Flow ◽  
Erectile Dysfunction ◽  
Adverse Events ◽  
Glycated Hemoglobin ◽  
Observational Cohort ◽  
Left And Right ◽  
Group 2 ◽  
The Right ◽  
Group 1

AIM:To assess the degree of changes in complaints, dynamics of biochemical parameters of lipid metabolism, penile hemodynamics in patients with ED during therapy with EDELIM in comparison with PDE-5 inhibitors. Assess the tolerability of the drug based on the analysis of reported adverse events. MATERIALS AND METHODS:The study was prospective comparative observational cohort. The study included 60 patients over 18 years old with complaints of persistent, at least 1 month, erectile dysfunction. The patients were divided into 2 groups: group 1 patients with ED received Edelim on a regular basis, one capsule 2 times daily for 3 months; group 2 patients with ED received generic tadalafil 5 mg daily for 1 month, then 1 month break, then 5 mg per day for 1 month. RESULTS:The mean age of the patients was 38.4 9.2 years. In group 1, significant differences were noted in the all hemodynamic and biochemical indicators, except for HDL levels (2.2 0.4 vs. 2.3 0.4 mmol/L;p= 0.067). In group 2, significant differences were noted in the dynamics of the IIEF-5 scale, the level of HDL, and the blood flow velocity in the right and left cavernous arteries. There were no significant differences in blood flow in the left and right dorsal arteries, levels of total cholesterol, LDL, triglycerides, glucose, HbA1c, systolic blood pressure. In the 1st group of patients, there were no adverse events, in the 2nd group, in 3 patients mild side effects. CONCLUSIONS:The improvement in the quality of erection in the group of patients taking Edelim is associated with decrease in the lipid profile, glucose, glycated hemoglobin, which can be regarded as a variant of pathogenetic conservative treatment of ED.

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