Effect of the cytokine network and role of intercellular adhesion molecules in endothelial dysfunction development in patients with acute myocardial infarction

Introduction. Exposure to mercury and its compounds can be a risk factor for the development of cardiovascular diseases. The aim of the study is to investigate the levels of antibodies to oxidized LDL, intercellular adhesion molecules sICAM-1, sVCAM-1, and VEGF in individuals exposed to mercury. Material and Methods. A cross-sectional examination was carried out using biochemical methods in persons who have come into contact with metallic mercury with a work experience of more than five years, persons with a first established diagnosis of chronic mercury intoxication, and patients with chronic mercury intoxication in the long-term postexposure period. Results. In persons exposed to mercury with concomitant cardiovascular diseases, the level of sVCAM-1 differed depending on the presence/absence of intoxication and acquired maximum values in its long-term period, while the concentrations of sICAM-1 and antibodies to oxidized LDL did not differ significantly. In the groups without cardiovascular pathology exposed to mercury, the concentration of sVCAM-1 was higher in patients with intoxication, and sICAM-1 was 1.5-2 times lower when compared with experienced individuals, the level of antibodies to oxidized LDL was maximum in the presence of intoxication in its initial period. Discussion. The progression of chronic mercury intoxication is accompanied by an increase in the level of sVCAM-1, and a gradual decrease in the content of sICAM-1 to reference values. Trained workers were found to have elevated sICAM-1 levels. Conclusion. The role of antibodies to oxidized LDL, intercellular adhesion molecules is their multidirectional participation in the mechanisms that inhibit or contribute to the formation of cardiovascular pathology in individuals exposed to mercury.

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Role of Cytokines and Adhesion Molecules in Ischemia and Reperfusion in Patients With Acute Myocardial Infarction

Japanese Circulation Journal ◽

10.1253/jcj.63.362 ◽

1999 ◽

Vol 63 (5) ◽

pp. 362-366 ◽

Cited By ~ 8

Author(s):

Yuji Miyao ◽

Shunichi Miyazaki ◽

Yoichi Goto ◽

Akira Itoh ◽

Satoshi Daikoku ◽

...

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Adhesion Molecules ◽

Ischemia And Reperfusion

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The Role of Smoking-Induced Alterations of Soluble Intercellular Adhesion Molecules in the Development of Chronic Obstructive Pulmonary Disease

Sovremennye tehnologii v medicine ◽

10.17691/stm2015.7.4.14 ◽

2015 ◽

Vol 7 (4) ◽

pp. 105-112

Author(s):

E.V. Makarova

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Adhesion Molecules ◽

Intercellular Adhesion ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Intercellular Adhesion Molecules

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Pathogenetic Relationship between Endothelial Dysfunction and Disorders of Blood Coagulation Potential in Pregnancy Complicated by Pre-Eclampsia

Annals of the Russian academy of medical sciences ◽

10.15690/vramn.v70.i5.1448 ◽

2015 ◽

Vol 70 (5) ◽

pp. 599-603 ◽

Cited By ~ 5

Author(s):

O. N. Sergeeva ◽

N. P. Chesnokova ◽

E. V. Ponukalina ◽

I. E. Rogozhina ◽

T. N. Glukhova

Keyword(s):

Nitric Oxide ◽

Endothelial Dysfunction ◽

Blood Plasma ◽

Blood Coagulation ◽

Adhesion Molecules ◽

Intercellular Adhesion ◽

Control Group ◽

Endothelin 1 ◽

Intercellular Adhesion Molecules ◽

Nitric Oxide Metabolites

Until now, there is no systematic information on the role of endothelial dysfunction in the mechanisms of disorders of blood coagulation potential and microcirculation in different organs and tissues in preeclampsia.Objective: Our aim was to extend the existing principles of diagnosis of pre-eclampsia by establishing the role of endothelial dysfunction in the mechanisms of blood coagulation potential violations. Methods: A prospective comparative study was performed. Condition of coagulation processes studied by conventional techniques, parameters of a functional endothelium (nitric oxide metabolites, endothelin 1, thrombospondin, thrombomodulin and intercellular adhesion molecules in blood plasma) — by ELISA.Results: The study group included 55 patients with moderate preeclampsia and 49 pregnant women with severe pre-eclampsia, in the control group — 40 women with physiological pregnancy. In patients with pre-eclampsia moderate observed increase in plasma endothelin-1 (p 0.001), thrombospondin (p 0.001), intercellular adhesion molecules (p 0.001) while reducing the level of nitrogen oxide (p 0.001), increase in time of fibrinolysis (p 0.050) and decreased international normalized ratio (p 0.050) compared with the control group. With increasing severity of preeclampsia the researchers detected in blood plasma of patients a progressive increase in endothelin 1 (p1 0.020), thrombospondin (p1 0.001), intercellular adhesion molecules (p1 0.001) and decrease of nitric oxide metabolites (p1 0.001) and thrombomodulin (p1 0.001); the last combined with the activation of procoagulant hemostasis.Conclusion: There is a pathogenetic relationship between the development of endothelial dysfunction, impaired blood coagulation potential and the severity of clinical signs of preeclampsia. To widen the number of existing techniques to diagnose the severity of pre-eclampsia we recommende to mesure endothelin 1, thrombomodulin, thrombospondin, intercellular adhesion molecules and nitric oxide metabolites in the blood plasma, and use traditional indicators to assess the hemostatic system.

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