Paget disease of the breast: A national retrospective analysis of the US population

2021 ◽  
Vol 39 (3-4) ◽  
pp. 119-126
Author(s):  
Andrea Sisti ◽  
Maria T. Huayllani ◽  
David J. Restrepo ◽  
Daniel Boczar ◽  
Pooja Advani ◽  
...  
Keyword(s):  
Survival Rate ◽  
Black People ◽  
Regional Lymph Node ◽  
Metastatic Cancer ◽  
Paget’S Disease ◽  
Tumor Grade ◽  
The United States ◽  
Paget's Disease ◽  
Partial Mastectomy ◽  
The Us

BACKGROUND: Paget’s disease of the breast is rare. The National Cancer Database (NCDB) is one of the largest tumor databases in the United States. METHODS: We queried the NCDB to identify male and female patients with Paget’s disease of the breast who were treated from January 1, 2004, through December 31, 2015. No age limitations were applied. Descriptive statistical analysis and survival analysis were performed. RESULTS: We analyzed the demographic, disease, and treatment characteristics of 7,191 patients with Paget’s disease of the breast. The median (range) age was 64 (20–90) years. Only 2.1% of patients were men, and 85.4% were white. The most common treatment was complete mastectomy (65.3%), followed by partial mastectomy (30.3%). Tumor destruction was performed in 0.1% of patients, and 4.3% of patients did not undergo any surgery. We examined survival in the subset of 6,864 patients who were treated surgically with complete mastectomy or partial mastectomy. The 5-year survival rate after surgery was 82.5% (95% CI, 81.1%–83.9%). Factors associated with shorter survival were older age, black race/ethnicity, higher tumor grade, regional lymph node metastasis, higher cancer stage, metastatic cancer, and larger tumor size. CONCLUSIONS: Paget’s disease of the breast usually affects patients older than 60 years, and the most common treatment is complete mastectomy. The 5-year overall survival rate of patients with Paget’s disease of the breast is greater than 80% but is lower among older and black people.

Metastatic Cancer in Paget's Disease of Bone: A Case Report

Orthopedics ◽  
1987 ◽  
Vol 10 (5) ◽  
pp. 725-729
Author(s):  
John J Nicholas ◽  
Charles H Srodes ◽  
David Herbert ◽  
Ronald J Roy ◽  
Robert L Peel ◽  
...  
Keyword(s):  
Case Report ◽  
Metastatic Cancer ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone

Sequestosome 1 (SQSTM1) Mutations in Paget’s Disease of Bone from the United States

2008 ◽  
Vol 82 (4) ◽  
pp. 271-277 ◽  
Author(s):  
Emily C. Rhodes ◽  
Teresa L. Johnson-Pais ◽  
Frederick R. Singer ◽  
Donna P. Ankerst ◽  
Jan M. Bruder ◽  
...  
Keyword(s):  
United States ◽  
Paget’S Disease ◽  
The United States ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone ◽  
Sequestosome 1

Synchronous primary ovarian and endometrial cancer in recent years: Changes in recent years.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e16554-e16554
Author(s):  
Maria Creselda deLeon ◽  
Giuseppe Del Priore ◽  
Deleep Gudipudi
Keyword(s):  
Endometrial Cancer ◽  
Disease Incidence ◽  
Tumor Grade ◽  
The United States ◽  
Disease Stage ◽  
Primary Ovarian Cancer ◽  
The Past ◽  
Included Patient ◽  
The Us ◽  
Age Of Diagnosis

e16554 Background: Patients with synchronous ovarian and endometrial cancer (SOEC) have been shown to have better prognosis when compared to patients with primary ovarian cancer alone; however with the increasing rate of obesity in the United States we hypothesize that this disease has significant characteristic changes compared to 20 years ago. Methods: This is retrospective study of patients with SOEC diagnosed between 1973-2009. We compared patients from 1973-1991 (n=962) to patients diagnosed between 1992-2009 (n=1800) when obesity became >10% of the US population starting in 1992. Using the Surveillance, Epidemiology, and End Results (SEER) registry, we obtained demographic information which included patient ID, primary site of tumor, year of diagnosis, sex, race, age group and survival months. SOEC was defined as diagnosis of ovarian and endometrial cancer within 0-12 months. Results: A query of SEOC yielded 2,762 women between the ages of 13-99 years. When we compared the stage of disease which was described as localized, regional, distant and unstaged, tumor grade and disease incidence, there was no difference found between the two groups. However when the age of diagnosis was compared, it was apparent that patients diagnosed between the years 1992-2009 were diagnosed at an earlier age 41-50 (28%) compared to patients diagnosed in 1973-1991 who were mostly diagnosed between ages 61-70 (31%) (p <0.001). Conclusions: We were able to demonstrate that women with SOEC in recent years are more likely to be diagnosed at an earlier age but that the disease stage, grade and incidence have stayed the same in the past 40 years. The hypothesis then that SOEC may have gone through some characteristic changes in the past 20 years seems plausible especially in the setting of increase incidence of obesity. [Table: see text]

The Inclusion Solution? The Use of Blackface in Jordan Peele’s "Get Out"

2020 ◽  
Author(s):  
Karolina Toka
Keyword(s):  
United States ◽  
Black People ◽  
The United States ◽  
First Century ◽  
Cultural Significance ◽  
American Popular Culture ◽  
Peculiar Form ◽  
The Us ◽  
Black Bodies

Jordan Peele’s 2017 social thriller Get Out depicts a peculiar form of body swap resulting from the uncanny desires of the Armitage family to seize captured black bodies and use them as carriers of their white minds. This paper offers a reading of the movie’s disturbing plot through the lens of the origins and cultural significance of blackface. For the sake of argument, in this article blackface is to be understood as a cultural phenomenon encompassing the symbolic role of black people basic to the US society, which articulates the ambiguity of celebration and exploitation of blackness in American popular culture. This article draws on the theoretical framework of blackface developed by Lott, Rogin, Ellison, and Gubar, in order to explore the Get Out’s complex commentary on the twenty-first century race relations in the United States. As a result, this paper turns the spotlight on the mechanisms of racist thinking in the United States, by showing the movie’s use of the apparatus underpinning blackface.

scholarly journals Prevalence of Extramammary Paget's Disease in Urban China: A Population-based Study

2020 ◽  
Author(s):  
Shilu Yin ◽  
Lu Xu ◽  
Shengfeng Wang ◽  
Jingnan Feng ◽  
Lili Liu ◽  
...  
Keyword(s):  
Paget’S Disease ◽  
Medical Insurance ◽  
The United States ◽  
Population Based ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Population Based Study ◽  
Basic Medical Insurance ◽  
Basic Medical ◽  
Extramammary Paget's Disease

Abstract Background Extramammary Paget’s disease (EMPD) is an intraepithelial adenocarcinoma. The chronic relapsing clinical course and unbearable clinical symptoms of EMPD usually result in a markedly diminished quality of life. No national data are available on descriptive epidemiology of EMPD in China, the most populous country over the world. This population-based study aimed to estimate the prevalence and associated sex and age patterns of EMPD in China. Methods This study was conducted using data from China’s Urban Employee Basic Medical Insurance and Urban Resident Basic Medical Insurance, covering approximately 0.43 billion Chinese urban residents in 2016. Patients with EMPD were identified based on the diagnostic names and codes in claim data. Results A total of 53 males and 31 females with EMPD were found. The crude prevalence in 2016 was 0.04 per 100 000 population [95% confidence interval (CI): 0.02 to 0.06], ranging from 0.01 (95% CI: 0.00 to 0.02) in North or Northeast China to 0.08 (95% CI: 0.03 to 0.16) in Southwest China. The rates were higher in males (0.05, 95% CI: 0.03 to 0.08) compared with females (0.03, 95% CI: 0.02 to 0.05). The mean age of patients was 65.87 (standard deviation: 14.21) years, with the peak prevalence appeared in patients aged 70–79 (0.28, 95% CI: 0.16 to 0.42). Conclusions The prevalence of EMPD was markedly lower than those in the United States and Europe, and varied across regions in China. Chinese patients were much younger, with significant male predominance. Further study is warranted to examine potential pathophysiologic mechanism.

Invasive vulvar extramammary Paget's disease in the United States

2020 ◽  
Vol 157 (3) ◽  
pp. 649-655 ◽  
Author(s):  
Toni P. Kilts ◽  
Beverly Long ◽  
Amy E. Glasgow ◽  
Jamie N. Bakkum-Gamez ◽  
Elizabeth B. Habermann ◽  
...  
Keyword(s):  
United States ◽  
Paget’S Disease ◽  
The United States ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Extramammary Paget's Disease

Prevalence of Pelvic Paget's Disease of Bone in the United States

2010 ◽  
Vol 15 (3) ◽  
pp. 461-465 ◽  
Author(s):  
R. D. Altman ◽  
D. A. Bloch ◽  
M. C. Hochberg ◽  
W. A. Murphy
Keyword(s):  
United States ◽  
Paget’S Disease ◽  
The United States ◽  
Paget's Disease ◽  
Paget’S Disease Of Bone ◽  
Paget's Disease Of Bone

scholarly journals Survival analysis of extramammary Paget’s disease (EMPD) in a tertiary hospital in Taiwan

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yu-Wei Chang ◽  
Hsu Ma ◽  
Wen-Chieh Liao
Keyword(s):  
Overall Survival ◽  
Survival Analysis ◽  
Survival Rate ◽  
Distant Metastasis ◽  
Paget’S Disease ◽  
Underlying Disease ◽  
Paget's Disease ◽  
Overall Survival Rate ◽  
Extramammary Paget's Disease

Abstract Background This study aimed to investigate the survival analysis of extramammary Paget’s disease (EMPD) in a Taiwanese population and to provide data for comparison with other studies in various locations and racial populations. Methods We retrospectively analyzed the medical records of 63 patients with EMPD who were surgically treated from 2002 to 2019 at a single institution. The primary endpoint was the 5-year overall survival rate of EMPD, and the secondary endpoint was recurrence-free 5-year survival. Independent variables included patients’ demographic data, concurrent malignancy (i.e., non-EMPD-related cancers), tumor size, distant metastasis, and surgery and/or radiation. Results Of all the 63 patients, 8 cases were excluded. A total of 43 patients (78.18%) were male, and 12 were female, with a mean age of 72.67 years (range 44–89 years). The most common affected anatomic site was the penoscrotal region (22 patients, 40.00%), followed by the perianal and perineal regions (17 patients, 30.91%). Among the 55 patients, 41 patients (74.55%) were diagnosed with at least one underlying disease, whereas the most common underlying disease was cardiovascular disease (30 patients, 54.55%). The overall survival rate was 80.00% at 36 months and 65.45% at the end of follow-up. EMPD with deep dermal invasion was a significant poor prognostic factor of overall survival in cause-specific hazard model (sub-hazard ratio (HR) 5.167, p = 0.0015, 95% confidence interval (CI) 1.876–14.230). Patients with regional metastasis or distant metastasis had poorer prognosis of 5-year survival (sub-HR 4.513, p = 0.0028, CI 1.683–12.103). The limitations of this study include its retrospective nature and sample size. Conclusions In our series, EMPD with metastasis and deep dermal invasion was the significant harmful factors in both overall 5-year survival and 5-year recurrence-free survival. The surgical excision is not associated with a low risk of local recurrence or overall survival, and long-term follow-up is still needed.

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