Efficacy and Safety of Sustained Release Donepezil High Dose versus Immediate Release Donepezil Standard Dose in Japanese Patients with Severe Alzheimer’s Disease: A Randomized, Double-Blind Trial

2016 ◽  
Vol 52 (1) ◽  
pp. 345-357 ◽  
Author(s):  
Akira Homma ◽  
Hirotsugu Atarashi ◽  
Naoki Kubota ◽  
Kenya Nakai ◽  
Takao Takase
2013 ◽  
Vol 21 (6) ◽  
pp. 586-593 ◽  
Author(s):  
Osamu Yamaguchi ◽  
Eiji Uchida ◽  
Naruhito Higo ◽  
Hidenao Minami ◽  
Shigeo Kobayashi ◽  
...  

2011 ◽  
Vol 5 (S1) ◽  
pp. 269-270
Author(s):  
T. Dietrich ◽  
R. Leeson ◽  
B. Zielińska-Kaźmierska ◽  
M. Opadczuk ◽  
E. Kozieł ◽  
...  

1997 ◽  
Vol 171 (1) ◽  
pp. 73-77 ◽  
Author(s):  
I. Pelc ◽  
P. Verbanck ◽  
O. Le Bon ◽  
M. Gavrilovic ◽  
K. Lion ◽  
...  

BackgroundAcamprosate is a newly registered drug that appears to reduce alcohol-drinking in both animal models and clinical conditions.MethodIn order to assess the efficacy and safety of the drug in the treatment of detoxified alcoholics, we performed a 90-day double-blind trial comparing two dosages of acamprosate (1332 mg/day and 1998 mg/day).ResultsFor all efficacy parameters, acamprosate appeared to be significantly superior to placebo, with a trend towards a better effect at the higher dosage. Furthermore, acamprosate appeared to be extremely safe.ConclusionThis study confirms that acamprosate could be an interesting adjuvant for maintaining abstinence in detoxified alcoholics.


1987 ◽  
Vol 46 (6) ◽  
pp. 1029-1034 ◽  
Author(s):  
V R Gordeuk ◽  
G M Brittenham ◽  
M Hughes ◽  
L J Keating ◽  
J J Opplt

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