Risk of Conversion to Dementia in a Mild Behavioral Impairment Group Compared to a Psychiatric Group and to a Mild Cognitive Impairment Group

ABSTRACT Objectives: To investigate conditional dependence relationships of impulse dyscontrol symptoms in mild cognitive impairment (MCI) and subjective cognitive decline (SCD). Design: A prospective, observational study. Participants: Two hundred and thirty-five patients with MCI (n = 159) or SCD (n = 76) from the Prospective Study for Persons with Memory Symptoms dataset. Measurements: Items of the Mild Behavioral Impairment Checklist impulse dyscontrol subscale. Results: Stubbornness/rigidity, agitation/aggressiveness, and argumentativeness were frequent and the most central symptoms in the network. Impulsivity, the fourth most central symptom in the network, served as the bridge between these common symptoms and less central and rare symptoms. Conclusions: Impulse dyscontrol in at-risk states for dementia is characterized by closely connected symptoms of irritability, agitation, and rigidity. Compulsions and difficulties in regulating rewarding behaviors are relatively isolated symptoms.

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Neuropsychiatric symptoms in subjective cognitive complaints (SCC) and mild cognitive impairment (MCI): Detecting changes over time with the Mild Behavioral Impairment Checklist (MBI‐C)

Alzheimer s & Dementia ◽

10.1002/alz.041963 ◽

2020 ◽

Vol 16 (S6) ◽

Author(s):

Sabela C. Mallo ◽

Arturo X. Pereiro ◽

Maria Campos‐Magdaleno ◽

Ana Nieto‐Vieites ◽

Cristina Lojo‐Seoane ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Neuropsychiatric Symptoms ◽

Cognitive Complaints ◽

Behavioral Impairment ◽

Changes Over Time ◽

Over Time ◽

Subjective Cognitive Complaints

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P1-277: THE ROLE OF THE MILD BEHAVIORAL IMPAIRMENT-CHECKLIST IN PREDICTING FUNCTIONALITY IN THE CONTINUUM FROM NORMAL AGING TO MILD COGNITIVE IMPAIRMENT

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.832 ◽

2019 ◽

Vol 15 ◽

pp. P346-P347

Author(s):

Sabela C. Mallo ◽

Onésimo Juncos-Rabadán ◽

David Facal ◽

Zahinoor Ismail ◽

Sietske A.M. Sikkes ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Normal Aging ◽

Behavioral Impairment ◽

The Continuum

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Comparison of Characteristics between Mild Cognitive Impairment Group and Normal Cognition Group Using the 4th Korean Longitudinal Study of Ageing

Chonnam Research Institute of Nursing Science ◽

10.33527/nhi2020.25.2.119 ◽

2020 ◽

Vol 25 (2) ◽

pp. 119-127

Author(s):

Hyo-Jin Park ◽

Ju-Young Ha

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Longitudinal Study ◽

Mild Cognitive Impairment Group ◽

Normal Cognition

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Assessing Mild Behavioral Impairment with the Mild Behavioral Impairment-Checklist in People with Mild Cognitive Impairment

Journal of Alzheimer s Disease ◽

10.3233/jad-180131 ◽

2018 ◽

Vol 66 (1) ◽

pp. 83-95 ◽

Cited By ~ 26

Author(s):

Sabela C. Mallo ◽

Zahinoor Ismail ◽

Arturo X. Pereiro ◽

David Facal ◽

Cristina Lojo-Seoane ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Behavioral Impairment

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Disrupted white matter integrity is associated with cognitive deficits in patients with amnestic mild cognitive impairment: An atlas-based study

SAGE Open Medicine ◽

10.1177/2050312116648812 ◽

2016 ◽

Vol 4 ◽

pp. 205031211664881 ◽

Cited By ~ 4

Author(s):

Duan Liu ◽

Zan Wang ◽

Hao Shu ◽

Zhijun Zhang

Keyword(s):

Cognitive Impairment ◽

Diffusion Tensor Imaging ◽

Mild Cognitive Impairment ◽

White Matter ◽

Diffusion Tensor ◽

Mean Diffusivity ◽

Amnestic Mild Cognitive Impairment ◽

Uncinate Fasciculus ◽

Radial Diffusivity ◽

Mild Cognitive Impairment Group

Objective: This study investigated white matter integrity in patients with amnestic mild cognitive impairment by diffusion tensor imaging. Methods: A total of 83 patients with amnestic mild cognitive impairment and 85 elderly healthy controls underwent neuropsychological testing and a diffusion tensor imaging scan. Whole-brain white matter data were parcellated into 50 regions based on the anatomical ICBM-DTI-81 atlas, and regional diffusion metrics consisting of fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity were calculated for each region. Diffusion tensor imaging indices were compared between groups, and it was determined that between-group differences were significantly correlated with neurocognitive performance. Results: Relative to the healthy controls group, the amnestic mild cognitive impairment group exhibited poorer cognitive performance in all neuropsychological tests except the complex figure test ( p = 0.083) and showed decreased mean fractional anisotropy in the fornix, increased mean diffusivity in the fornix and bilateral uncinate fasciculus, elevated axial diffusivity in the fornix and genu of corpus callosum, and elevated radial diffusivity in the fornix and bilateral uncinate fasciculus ( p < 0.05). Behaviorally, integrity of the bilateral uncinate fasciculus was correlated positively with episodic memory function, while left uncinate fasciculus integrity was positively associated with language function in the amnestic mild cognitive impairment group ( p < 0.05). Conclusion: White matter abnormalities in neural pathways associated with memory were correlated with neurocognitive deficiencies in amnestic mild cognitive impairment. Given that amnestic mild cognitive impairment is putatively a prodromal syndrome for Alzheimer’s disease, this study furthers our understanding of the white matter changes associated with Alzheimer’s disease pathogenesis in the predementia stage.

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The Association Between Diabetes Mellitus and Mild Behavioral Impairment Among Mild Cognitive Impairment: Findings from Singapore

Journal of Alzheimer s Disease ◽

10.3233/jad-210037 ◽

2021 ◽

pp. 1-10

Author(s):

See Ann Soo ◽

Kok Pin Ng ◽

Fennie Wong ◽

Seyed Ehsan Saffari ◽

Chathuri Yatawara ◽

...

Keyword(s):

Diabetes Mellitus ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Regression Models ◽

Later Life ◽

Emotional Dysregulation ◽

Behavioral Changes ◽

Behavioral Impairment ◽

Cognitively Normal ◽

Domain Scores

Background: Mild behavioral impairment (MBI) describes persistent behavioral changes in later life as an at-risk state for dementia. While cardiovascular risk factors (CVRFs) are linked to dementia, it is uncertain how CVRFs are associated with MBI. Objective: To determine the prevalence of MBI and its association with CVRFs among cognitively normal (CN) and mild cognitive impairment (MCI) individuals in Singapore. Methods: 172 individuals (79 CN and 93 MCI) completed the MBI-checklist (MBI-C). The prevalence of MBI and MBI-C sub-domain characteristics among CN and MCI were examined. Regression models evaluated the relationships between MBI-C sub-domain scores with CVRFs. Results: The prevalence of MBI and mean MBI-C total score were significantly higher among MCI than CN (34.4%versus 20.3%, p = 0.022 and 7.01 versus 4.12, p = 0.04). The highest and lowest-rated sub-domains among CN and MCI were impulse dyscontrol and abnormal thoughts and perception respectively. Within the MCI cohort, a higher proportion of individuals with diabetes mellitus (DM) had MBI compared to individuals without DM (28.1%versus 10.4%, p = 0.025). The interaction of DM and MCI cohort resulted in significantly higher mean MBI-C total, decreased motivation, emotional dysregulation, impulse dyscontrol, and abnormal thoughts and perception sub-domain scores. Conclusion: The prevalence of MBI is higher among a Singapore cohort compared to Caucasian cohorts. The associations of DM with both the presence and severity of MBI among MCI suggest that DM may be a risk factor for MBI. The optimization of DM may be a potential therapeutic approach to improve clinical outcomes among MCI with MBI.

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Prevalence, neurobiology, and treatments for apathy in prodromal dementia

International Psychogeriatrics ◽

10.1017/s1041610217000527 ◽

2017 ◽

Vol 30 (2) ◽

pp. 177-184 ◽

Cited By ~ 14

Author(s):

Chelsea Sherman ◽

Celina S. Liu ◽

Nathan Herrmann ◽

Krista L. Lanctôt

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Literature Search ◽

Neuropsychiatric Symptom ◽

Prevalence Rates ◽

Pharmacological Treatments ◽

Pharmacological Interventions ◽

Behavioral Impairment ◽

Prodromal Dementia ◽

Comprehensive Literature Search

ABSTRACTBackground:Apathy, characterized by diminished motivation, is a highly prevalent neuropsychiatric symptom in dementia. However, there is a substantial knowledge gap with regard to prevalence rates, neurobiological underpinnings, and effective treatments for apathy in pre-dementia states, including mild cognitive impairment (MCI) and mild behavioral impairment (MBI).Methods:We conducted a comprehensive literature search using MEDLINE, Embase, and PsycINFO databases to identify available research on apathy in prodromal dementia.Results:Apathy has consistently been detected in individuals with MCI with varying prevalence rates, and only recently has literature discussed the prevalence of apathy in MBI. Few pharmacological treatments have been utilized for apathy, with galantamine and risperidone showing mild reductions in apathetic behaviors. Non-pharmacological interventions in prodromal dementia are beginning to be explored and show promise, but few studies have replicated those results.Discussion:More comprehensive guidelines for diagnosing apathy and further research investigating neurobiological mechanisms of apathy in MCI and MBI are required in order to effectively treat apathetic patients in prodromal dementia.

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