Intrinsic Alertness Is Impaired in Patients with Nigrostriatal Degeneration: A Prospective Study with Reference to [123I]FP-CIT SPECT and [18F]FDG PET

2020 ◽  
Vol 78 (4) ◽  
pp. 1721-1729
Author(s):  
Lars Frings ◽  
Bernhard Heimbach ◽  
Philipp T. Meyer ◽  
Sabine Hellwig
Keyword(s):  
Fdg Pet ◽  
Statistical Parametric Mapping ◽  
Lewy Bodies ◽  
Reaction Times ◽  
Potential Measure ◽  
18F Fdg ◽  
Nigrostriatal Degeneration ◽  
Spect Scan ◽  
A Prospective Study ◽  
Core Features

Background: Variations in alertness and attention are common in Lewy body diseases (LBD) and among the core features of dementia with Lewy bodies (DLB). Dopamine transporter SPECT is an accurate biomarker of nigrostriatal degeneration (NSD) in LBD. Objective: The present study investigated performance on a computerized alertness test as a potential measure of attention in patients with NSD compared to patients without NSD. Methods: Thirty-six patients with cognitive impairment plus at least one core feature of DLB referred for [123I]FP-CIT SPECT imaging were prospectively recruited. Performance in a computerized test of intrinsic alertness was compared between patients with and those without NSD as assessed by [123I]FP-CIT SPECT. Results: Reaction times to auditory stimuli (adjusted for age, sex, and education) were significantly longer in patients with NSD compared to those with a normal [123I]FP-CIT SPECT scan (p < 0.05). Statistical analyses revealed no significant differences comparing reaction times to visual stimuli or dispersion of reaction times between groups. Exploratory analysis in a subgroup of patients with available [18F]FDG PET revealed that longer reaction times were associated with decreased glucose metabolism in the prefrontal cortex (statistical parametric mapping, adjusted for age and sex; p < 0.005, cluster extent > 50 voxels). Conclusion: Computerized assessment of auditory reaction times is able to detect alertness deficits in patients with NSD and might help to measure alertness deficits in patients with LBD and NSD. Future studies in larger samples are needed to evaluate the diagnostic utility of computerized alertness assessment for the differential diagnosis of LBD.

scholarly journals Brain Metabolic Correlates of Persistent Olfactory Dysfunction after SARS-Cov2 Infection

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 287
Author(s):  
Maria Isabella Donegani ◽  
Alberto Miceli ◽  
Matteo Pardini ◽  
Matteo Bauckneht ◽  
Silvia Chiola ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Structural Connectivity ◽  
Statistical Parametric Mapping ◽  
Brain Regions ◽  
Olfactory Dysfunction ◽  
Whole Body ◽  
Mapping Software ◽  
18F Fdg ◽  
Left Insula

We aimed to evaluate the brain hypometabolic signature of persistent isolated olfactory dysfunction after SARS-CoV-2 infection. Twenty-two patients underwent whole-body [18F]-FDG PET, including a dedicated brain acquisition at our institution between May and December 2020 following their recovery after SARS-Cov2 infection. Fourteen of these patients presented isolated persistent hyposmia (smell diskettes olfaction test was used). A voxel-wise analysis (using Statistical Parametric Mapping software version 8 (SPM8)) was performed to identify brain regions of relative hypometabolism in patients with hyposmia with respect to controls. Structural connectivity of these regions was assessed (BCB toolkit). Relative hypometabolism was demonstrated in bilateral parahippocampal and fusiform gyri and in left insula in patients with respect to controls. Structural connectivity maps highlighted the involvement of bilateral longitudinal fasciculi. This study provides evidence of cortical hypometabolism in patients with isolated persistent hyposmia after SARS-Cov2 infection. [18F]-FDG PET may play a role in the identification of long-term brain functional sequelae of COVID-19.

Changes of metabolic connectivity in dementia with Lewy bodies with visual hallucinations: a 18F-FDG PET/MR study

2021 ◽  
Author(s):  
Giovanni Zorzi ◽  
Diego Cecchin ◽  
Cinzia Busse ◽  
Giulia Perini ◽  
Maurizio Corbetta ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Visual Hallucinations ◽  
Metabolic Connectivity ◽  
18F Fdg ◽  
Mr Study

Single-subject SPM FDG-PET patterns predict risk of dementia progression in Parkinson disease

Neurology ◽  
2018 ◽  
Vol 90 (12) ◽  
pp. e1029-e1037 ◽  
Author(s):  
Andrea Pilotto ◽  
Enrico Premi ◽  
Silvia Paola Caminiti ◽  
Luca Presotto ◽  
Rosanna Turrone ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Fdg Pet ◽  
Cognitive Assessment ◽  
Disease Duration ◽  
Age At Onset ◽  
Statistical Parametric Mapping ◽  
Lewy Bodies ◽  
Single Subject ◽  
Incident Dementia

ObjectiveTo evaluate the statistical parametric mapping (SPM) procedure for fluorodeoxyglucose (FDG)-PET imaging as a possible single-subject marker of progression to dementia in Parkinson disease (PD).MethodsFifty-four consecutive patients with PD without dementia (age at onset of 59.9 ± 10.1 years, disease duration of 5.3 ± 3.4 years) entered the study. The patients underwent an extensive motor and cognitive assessment and a single-subject FDG-PET SPM evaluation at baseline. A 4-year follow-up provided disease progression and dementia diagnosis.ResultsThe FDG-PET SPM was evaluated by 2 expert raters allowing the identification of a “typical PD pattern” in 29 patients, whereas 25 patients presented with “atypical patterns,” namely, dementia with Lewy bodies (DLB)-like (n = 12), Alzheimer disease (AD)-like (n = 6), corticobasal syndrome (CBS)-like (n = 5), and frontotemporal dementia (FTD)-like (n = 2). At 4-year follow-up, 13 patients, all showing atypical brain metabolic patterns at baseline, progressed to dementia (PD dementia). The DLB- and AD-like SPM patterns were the best predictor for incident dementia (p < 0.005, sensitivity 85%, specificity 88%), independently from demographics or cognitive baseline classification.ConclusionsThis study suggests that FDG-PET SPM at the single-subject level might help in identifying patients with PD at risk of developing dementia.

scholarly journals Diagnostic Performance of Simultaneous [18F]-FDG PET/MR for Assessing Endoscopically Active Inflammation in Patients with Ulcerative Colitis: A Prospective Study

2020 ◽  
Vol 9 (8) ◽  
pp. 2474
Author(s):  
Jost Langhorst ◽  
Lale Umutlu ◽  
Benedikt Michael Schaarschmidt ◽  
Johannes Grueneisen ◽  
Aydin Demircioglu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Standard Uptake Value ◽  
Mr Enterography ◽  
Metabolic Conditions ◽  
18F Fdg ◽  
A Prospective Study ◽  
Active Inflammation ◽  
Bowel Segments

Background: To investigate the diagnostic performance of simultaneous 18F-fluoro-deoxyglucose ([18F]-FDG) PET/MR enterography in assessing and grading endoscopically active inflammation in patients with ulcerative colitis. Methods: 50 patients underwent PET/MR 24 h before ileocolonoscopy. Inflammatory activities of bowel segments were evaluated with both Mayo endoscopic subscore and Nancy histologic index. MR, DWI (Diffusion-weighted imaging) and PET were utilized as qualitative parameters for detecting endoscopically active inflammation. SUVmaxQuot in each segment (maximum of standard uptake value relative to liver) was calculated to quantify inflammation. Results: In the study arm without bowel purgation, combined reading of PET and MR resulted in significantly increased specificity against each submodality alone (0.944 vs. 0.82 for MR and 0.843 for PET, p < 0.05) and highest overall accuracy. In the study arm with bowel purgation, the significantly lower specificity of PET (0.595) could be markedly improved by a combined reading of PET and MR. Metabolic conditions in bowel segments with both endoscopic and histological remission were significantly lower than in segments with endoscopic remission but persistent microscopic inflammation (SUVmaxQuot 0.719 vs. 0.947, p < 0.001). SUVmaxQuot correlated highly with Mayo endoscopic subscore (ρ = 0.718 and 0.606) and enabled grading of inflammatory activity. Conclusions: Simultaneous [18F]-FDG PET/MR may be considered as an alternative to endoscopy in clinical trials.

Role of 18F-FDG PET/CT in the diagnosis of infective endocarditis in patients with an implanted cardiac device: a prospective study

2014 ◽  
Vol 41 (8) ◽  
pp. 1617-1623 ◽  
Author(s):  
Maddalena Graziosi ◽  
Cristina Nanni ◽  
Massimiliano Lorenzini ◽  
Igor Diemberger ◽  
Rachele Bonfiglioli ◽  
...  
Keyword(s):  
Infective Endocarditis ◽  
Prospective Study ◽  
Fdg Pet ◽  
Cardiac Device ◽  
Pet Ct ◽  
18F Fdg ◽  
A Prospective Study ◽  
Fdg Pet Ct

scholarly journals Role of 18F-FDG PET-CT in Vasculitis: a Prospective Study

JMED Research ◽  
2014 ◽  
pp. 1-14
Author(s):  
Kinga Siczek ◽  
◽  
Paola Faggioli ◽  
Emanuela Venegoni ◽  
Luigia Florimonte ◽  
...  
Keyword(s):  
Prospective Study ◽  
Fdg Pet ◽  
Pet Ct ◽  
18F Fdg ◽  
A Prospective Study ◽  
Fdg Pet Ct
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