Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts

2020 ◽  
Vol 77 (1) ◽  
pp. 323-337
Author(s):  
Can Sheng ◽  
Yu Sun ◽  
Min Wang ◽  
Xiaoni Wang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Medial Temporal Lobe ◽  
Rating Scales ◽  
Rating Scale ◽  
Discriminative Power ◽  
Medial Temporal Lobe Atrophy ◽  
Cognitively Normal ◽  
Visual Rating ◽  
Visual Rating Scale ◽  
Visual Assessments ◽  
Lobe Atrophy

Background: Visual rating scales for medial temporal lobe atrophy (MTA) and posterior atrophy (PA) have been reported to be useful for Alzheimer’s disease diagnosis in routine clinical practice. Objective: To investigate the efficacy of combined MTA and PA visual rating scales to discriminate amnestic mild cognitive impairment (aMCI) patients from healthy controls. Methods: This study included T1-weighted MRI images from two different cohorts. In the first cohort, we recruited 73 patients with aMCI and 48 group-matched cognitively normal controls for training and validation. Visual assessments of MTA and PA were carried out for each participant. Global gray matter volume and density were estimated using voxel-based morphometry analysis as the objective reference. We investigated the discriminative power of a single visual rating scale and the combination of the MTA and PA rating scales for identifying aMCI. The second cohort, consisting of 33 aMCI patients and 45 controls, was used to verify the reliability of the visual assessments. Results: Compared with the single visual rating scale, the combination of the MTA and PA exhibited the best discriminative power, with an AUC of 0.818±0.041, which was similar to the diagnostic accuracy of the gray matter volumetric measures. The discriminative power of the combined MTA and PA was verified in the second cohort (AUC 0.824±0.058). Conclusion: The combined MTA and PA rating scales demonstrated practical diagnostic value for distinguishing aMCI patients from controls, suggesting its potential to serve as a convenient and reproducible method to assess the degree of atrophy in clinical settings.

scholarly journals Combining visual rating scales of medial temporal lobe atrophy and posterior atrophy to identify amnestic mild cognitive impairment from cognitively normal older adults: evidence based on two datasets

2019 ◽  
Author(s):  
Can Sheng ◽  
Yu Sun ◽  
Min Wang ◽  
Xiaoni Wang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Medial Temporal Lobe ◽  
Rating Scales ◽  
Amnestic Mild Cognitive Impairment ◽  
Discriminative Power ◽  
Medial Temporal Lobe Atrophy ◽  
Cognitively Normal ◽  
Visual Rating ◽  
Lobe Atrophy ◽  
Posterior Atrophy

Abstract Background: Structural magnetic resonance imaging (MRI)-based visual rating scales are considered as the primary method for rapid and cost-effective evaluation of regional brain atrophy in patients with Alzheimer’s disease (AD) in routine clinical practice. Both medial temporal lobe atrophy (MTA) and posterior atrophy (PA) visual rating scales have been reported to be useful in AD diagnosis. However, very few existing studies have investigated the efficacy of combined MTA and PA for identification of amnestic mild cognitive impairment (aMCI) from cognitively normal elderly.Methods: This study included T1-weighted MRI images acquired inXuanwu Hospital of Capital Medical University, Beijing, China from two different cohorts. In the first cohort, we recruited 73 patients with aMCI and 48 group-matched cognitively normal controls for the training and validation. Visual assessments of MTA and PA, including left MTA, right MTA, mean MTA, left PA, right PA and mean PA, were carried out from each participant. Global gray matter (GM) volume and density was estimated using voxel-based morphometry analysis as the objective reference. Based on the receiver operating characteristic (ROC) analysis, we investigated the discriminative power of single visual rating scale and the combination of MTA and PA for successful classification between the two diagnostic groups, respectively, and then compared them to GM measures. The second cohort, consisted of 33 aMCI patients and 45 NCs, was used to verify the reliability of the discriminative power of visual assessments.Results: In the first cohort, visual rating scales of MTA and PA showed different potential to distinguish aMCI from controls. Moreover, the combination of MTA and PA exhibited the best discriminative power, with the AUC of 0.818 ± 0.041, which was similar to the diagnostic accuracy of GM volumetric measures (0.857 ± 0.034). The discriminative power was verified in the second cohort when combining MTA and PA visual rating scales, with the AUC of 0.824 ± 0.058.Conclusion: The combined visual rating scales of MTA and PA demonstrated practical diagnostic values for distinguishing aMCI patients from controls, suggesting its potential to serve as a convenient and reproducible method to assess the degree of atrophy in the clinical setting.

scholarly journals Usefulness of medial temporal lobe atrophy visual rating scale in detecting Alzheimer′s disease: Preliminary study

2013 ◽  
Vol 16 (3) ◽  
pp. 384 ◽  
Author(s):  
Jae-Hyeok Heo ◽  
Min-Ky Kim ◽  
Jun-Hyung Lee ◽  
Jeong-Heon Lee
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Rating Scale ◽  
Medial Temporal Lobe Atrophy ◽  
Visual Rating ◽  
Visual Rating Scale ◽  
Preliminary Study ◽  
Lobe Atrophy

scholarly journals Modified Visual Magnetic Resonance Rating Scale for Evaluation of Patients with Forgetfulness

2018 ◽  
Vol 46 (1) ◽  
pp. 71-78
Author(s):  
Betul Z. Yalciner ◽  
Melek Kandemir ◽  
Sencan Taskale ◽  
Savas M. Tepe ◽  
Devrim Unay
Keyword(s):  
Medial Temporal Lobe ◽  
Rating Scale ◽  
Daily Practice ◽  
Medial Temporal Lobe Atrophy ◽  
Cranial Mri ◽  
The Mean ◽  
Depression Scales ◽  
State Examination ◽  
Depressive Patients ◽  
Lobe Atrophy

AbstractBackgroundAs cognitive impairment increases with age, sulcal atrophy (SA) and the enlargement of the ventricles also increase. Considering the measurements on the previously proposed visual scales, a new scale is proposed in this study that allows us to evaluate the atrophy, white matter hyperintensities (WMHs), basal ganglia infarct (BGI), and infratentorial infarct (ITI) together. Our aim of this study is to propose a practical and standardized MRI for the clinicians to be used in daily practice.MethodsA total of 97 patients older than 60 years and diagnosed with depression or Alzheimer’s disease (AD) are included. Cranial MRI, Mini Mental State Examination (MMSE), detailed neuropsychometric tests, and depression scales are applied to all patients. The SA, ventricular atrophy (VA), medial temporal lobe atrophy (MTA), periventricular WMH (PWMH), subcortical WMH (SCWMH), BGI, and ITI are scored according to the scale. The total score is also recorded.ResultsThe average age of the patients was 74.53, and the mean MMSE score was 22.7 in the degenerative group and 27.8 in the non-degenerative group. Among the patients, 50 were diagnosed with AD. All parameters significantly increased with age. In the degenerative group, SA, VA, MTA, PWMH, SCWMH, and total scores were found to be significantly higher. Sensitivities of VA, PWMH, SCWMH, and total scores, as well as both sensitivity and specificities of MTA score, were observed to be high. When they were combined, sensitivities and specificities were found to be high.ConclusionThe scale is observed to be predictive in discriminating degenerative and non-degenerative processes. This discrimination is important, particularly in depressive patients complaining of forgetfulness.

scholarly journals Unravelling drivers of age‐ and beta‐amyloid‐related neurodegeneration in medial temporal lobe atrophy in cognitively normal older adults

2021 ◽  
Vol 17 (S1) ◽  
Author(s):  
Anika Wuestefeld ◽  
David Berron ◽  
Danielle van Westen ◽  
Erik Stomrud ◽  
Niklas Mattsson‐Carlgren ◽  
...  
Keyword(s):  
Older Adults ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Beta Amyloid ◽  
Medial Temporal Lobe Atrophy ◽  
Cognitively Normal ◽  
Lobe Atrophy

Medial temporal lobe atrophy in vascular dementia: Visual temporal lobe rating scale

2009 ◽  
Vol 48 (3) ◽  
pp. 415-418 ◽  
Author(s):  
Hyun Cho ◽  
Jee-Hyun Kwon ◽  
Hyun-Jin Seo
Keyword(s):  
Vascular Dementia ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Rating Scale ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy

scholarly journals New visual rating system for medial temporal lobe atrophy: a simple diagnostic tool for routine examinations

2012 ◽  
Vol 12 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Tomoki KANEKO ◽  
Kikuko KANEKO ◽  
Mina MATSUSHITA ◽  
Masumi KADOYA ◽  
Nobumaro IHARA ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Diagnostic Tool ◽  
Medial Temporal Lobe ◽  
Rating System ◽  
Medial Temporal Lobe Atrophy ◽  
Visual Rating ◽  
Lobe Atrophy

scholarly journals Evaluation of MR Visual Rating Scales in Major Forms of Dementia

2020 ◽  
Author(s):  
Surabhi Kaushik ◽  
Kavita Vani ◽  
Shishir Chumber ◽  
Kuljeet Singh Anand ◽  
Rajinder K. Dhamija
Keyword(s):  
Frontal Lobe ◽  
Medial Temporal Lobe ◽  
Rating Scales ◽  
Parietal Lobe ◽  
Pearson Correlation ◽  
Significant Negative Correlation ◽  
Cortical Atrophy ◽  
P Value ◽  
Visual Rating ◽  
Lobe Atrophy

Abstract Objective The aim of the study is to visually rate major forms of dementia using global cortical atrophy (GCA), medial temporal lobe atrophy (MTA), and Fazeka’s scales and Koedam’s score using magnetic resonance imaging (MRI). The purpose is to correlate the visual rating scales (VRS) with severity of dementia. Materials and Methods Thirty patients fulfilling DSM 5 (Diagnostic and Statistical Manual of Mental Disorders) criteria for Alzheimer’s dementia (AD), vascular dementia (VaD), and frontotemporal dementia (FTD) underwent MRI brain. Cortical atrophy, medial temporal, and parietal lobe atrophy were assessed using GCA and MTA scales and Koedam’s score, respectively. White matter hyperintensities were assessed using Fazeka’s scale. Correlation between VRS and mini-mental state exam (MMSE) scores was done using Pearson correlation coefficient. Results 70% of patients had Grade 2 GCA. More patients with AD had higher MTA scores as compared with others with 57% of AD patients showing abnormal for age MTA scores. Fazeka’s scale was abnormal for age in 58.33% of VaD and 57% AD patients. Majority (75%) showing severe parietal atrophy (Grade 3 Koedam’s score) were AD patients. Disproportionate frontal lobe atrophy was seen in all four (100%) FTD patients. Significant negative correlation was seen between MMSE and GCA scores of all patients (p-value = 0.003) as well as between MTA and MMSE scores in AD patients (p-value = 0.00095). Conclusion Visual rating of MTA is a reliable method for detecting AD and correlates strongly with memory scores. Atrophy of specific regions is seen more commonly in some conditions, for instance, where MTA and parietal atrophy are specific for AD while asymmetric frontal lobe and temporal pole atrophy favor FTD.

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