scholarly journals Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data

2018 ◽  
Vol 14 (3) ◽  
pp. 275 ◽  
Author(s):  
Gyeong Seon Choi ◽  
Geon Ha Kim ◽  
Ji-Hyun Choi ◽  
Jihye Hwang ◽  
Eunjin Kwon ◽  
...  
Keyword(s):  
South Korea ◽  
Clinical Research ◽  
Medial Temporal Lobe ◽  
Rating Scale ◽  
Medial Temporal Lobe Atrophy ◽  
Visual Rating ◽  
Clinical Research Center ◽  
Visual Rating Scale ◽  
Cutoff Scores ◽  
Lobe Atrophy

Combining Visual Rating Scales for Medial Temporal Lobe Atrophy and Posterior Atrophy to Identify Amnestic Mild Cognitive Impairment from Cognitively Normal Older Adults: Evidence Based on Two Cohorts

2020 ◽  
Vol 77 (1) ◽  
pp. 323-337
Author(s):  
Can Sheng ◽  
Yu Sun ◽  
Min Wang ◽  
Xiaoni Wang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Medial Temporal Lobe ◽  
Rating Scales ◽  
Rating Scale ◽  
Discriminative Power ◽  
Medial Temporal Lobe Atrophy ◽  
Cognitively Normal ◽  
Visual Rating ◽  
Visual Rating Scale ◽  
Visual Assessments ◽  
Lobe Atrophy

Background: Visual rating scales for medial temporal lobe atrophy (MTA) and posterior atrophy (PA) have been reported to be useful for Alzheimer’s disease diagnosis in routine clinical practice. Objective: To investigate the efficacy of combined MTA and PA visual rating scales to discriminate amnestic mild cognitive impairment (aMCI) patients from healthy controls. Methods: This study included T1-weighted MRI images from two different cohorts. In the first cohort, we recruited 73 patients with aMCI and 48 group-matched cognitively normal controls for training and validation. Visual assessments of MTA and PA were carried out for each participant. Global gray matter volume and density were estimated using voxel-based morphometry analysis as the objective reference. We investigated the discriminative power of a single visual rating scale and the combination of the MTA and PA rating scales for identifying aMCI. The second cohort, consisting of 33 aMCI patients and 45 controls, was used to verify the reliability of the visual assessments. Results: Compared with the single visual rating scale, the combination of the MTA and PA exhibited the best discriminative power, with an AUC of 0.818±0.041, which was similar to the diagnostic accuracy of the gray matter volumetric measures. The discriminative power of the combined MTA and PA was verified in the second cohort (AUC 0.824±0.058). Conclusion: The combined MTA and PA rating scales demonstrated practical diagnostic value for distinguishing aMCI patients from controls, suggesting its potential to serve as a convenient and reproducible method to assess the degree of atrophy in clinical settings.

scholarly journals Modified Visual Magnetic Resonance Rating Scale for Evaluation of Patients with Forgetfulness

2018 ◽  
Vol 46 (1) ◽  
pp. 71-78
Author(s):  
Betul Z. Yalciner ◽  
Melek Kandemir ◽  
Sencan Taskale ◽  
Savas M. Tepe ◽  
Devrim Unay
Keyword(s):  
Medial Temporal Lobe ◽  
Rating Scale ◽  
Daily Practice ◽  
Medial Temporal Lobe Atrophy ◽  
Cranial Mri ◽  
The Mean ◽  
Depression Scales ◽  
State Examination ◽  
Depressive Patients ◽  
Lobe Atrophy

AbstractBackgroundAs cognitive impairment increases with age, sulcal atrophy (SA) and the enlargement of the ventricles also increase. Considering the measurements on the previously proposed visual scales, a new scale is proposed in this study that allows us to evaluate the atrophy, white matter hyperintensities (WMHs), basal ganglia infarct (BGI), and infratentorial infarct (ITI) together. Our aim of this study is to propose a practical and standardized MRI for the clinicians to be used in daily practice.MethodsA total of 97 patients older than 60 years and diagnosed with depression or Alzheimer’s disease (AD) are included. Cranial MRI, Mini Mental State Examination (MMSE), detailed neuropsychometric tests, and depression scales are applied to all patients. The SA, ventricular atrophy (VA), medial temporal lobe atrophy (MTA), periventricular WMH (PWMH), subcortical WMH (SCWMH), BGI, and ITI are scored according to the scale. The total score is also recorded.ResultsThe average age of the patients was 74.53, and the mean MMSE score was 22.7 in the degenerative group and 27.8 in the non-degenerative group. Among the patients, 50 were diagnosed with AD. All parameters significantly increased with age. In the degenerative group, SA, VA, MTA, PWMH, SCWMH, and total scores were found to be significantly higher. Sensitivities of VA, PWMH, SCWMH, and total scores, as well as both sensitivity and specificities of MTA score, were observed to be high. When they were combined, sensitivities and specificities were found to be high.ConclusionThe scale is observed to be predictive in discriminating degenerative and non-degenerative processes. This discrimination is important, particularly in depressive patients complaining of forgetfulness.

scholarly journals Combining visual rating scales of medial temporal lobe atrophy and posterior atrophy to identify amnestic mild cognitive impairment from cognitively normal older adults: evidence based on two datasets

2019 ◽  
Author(s):  
Can Sheng ◽  
Yu Sun ◽  
Min Wang ◽  
Xiaoni Wang ◽  
Yi Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Medial Temporal Lobe ◽  
Rating Scales ◽  
Amnestic Mild Cognitive Impairment ◽  
Discriminative Power ◽  
Medial Temporal Lobe Atrophy ◽  
Cognitively Normal ◽  
Visual Rating ◽  
Lobe Atrophy ◽  
Posterior Atrophy

Abstract Background: Structural magnetic resonance imaging (MRI)-based visual rating scales are considered as the primary method for rapid and cost-effective evaluation of regional brain atrophy in patients with Alzheimer’s disease (AD) in routine clinical practice. Both medial temporal lobe atrophy (MTA) and posterior atrophy (PA) visual rating scales have been reported to be useful in AD diagnosis. However, very few existing studies have investigated the efficacy of combined MTA and PA for identification of amnestic mild cognitive impairment (aMCI) from cognitively normal elderly.Methods: This study included T1-weighted MRI images acquired inXuanwu Hospital of Capital Medical University, Beijing, China from two different cohorts. In the first cohort, we recruited 73 patients with aMCI and 48 group-matched cognitively normal controls for the training and validation. Visual assessments of MTA and PA, including left MTA, right MTA, mean MTA, left PA, right PA and mean PA, were carried out from each participant. Global gray matter (GM) volume and density was estimated using voxel-based morphometry analysis as the objective reference. Based on the receiver operating characteristic (ROC) analysis, we investigated the discriminative power of single visual rating scale and the combination of MTA and PA for successful classification between the two diagnostic groups, respectively, and then compared them to GM measures. The second cohort, consisted of 33 aMCI patients and 45 NCs, was used to verify the reliability of the discriminative power of visual assessments.Results: In the first cohort, visual rating scales of MTA and PA showed different potential to distinguish aMCI from controls. Moreover, the combination of MTA and PA exhibited the best discriminative power, with the AUC of 0.818 ± 0.041, which was similar to the diagnostic accuracy of GM volumetric measures (0.857 ± 0.034). The discriminative power was verified in the second cohort when combining MTA and PA visual rating scales, with the AUC of 0.824 ± 0.058.Conclusion: The combined visual rating scales of MTA and PA demonstrated practical diagnostic values for distinguishing aMCI patients from controls, suggesting its potential to serve as a convenient and reproducible method to assess the degree of atrophy in the clinical setting.

scholarly journals New visual rating system for medial temporal lobe atrophy: a simple diagnostic tool for routine examinations

2012 ◽  
Vol 12 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Tomoki KANEKO ◽  
Kikuko KANEKO ◽  
Mina MATSUSHITA ◽  
Masumi KADOYA ◽  
Nobumaro IHARA ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Diagnostic Tool ◽  
Medial Temporal Lobe ◽  
Rating System ◽  
Medial Temporal Lobe Atrophy ◽  
Visual Rating ◽  
Lobe Atrophy

P1-339: Medial temporal lobe atrophy in vascular dementia: Visual temporal lobe rating scale

2008 ◽  
Vol 4 ◽  
pp. T318-T318
Author(s):  
Hyun Cho ◽  
Kwon Jee-Hyun ◽  
Hyun Jin Seo ◽  
Seung Ho Choi ◽  
Sung Yul Kim ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Rating Scale ◽  
Medial Temporal Lobe Atrophy ◽  
Lobe Atrophy

scholarly journals Inter-modality assessment of medial temporal lobe atrophy in a non-demented population: application of a visual rating scale template across radiologists with varying clinical experience

2021 ◽  
Author(s):  
Claes Håkansson ◽  
Ashkan Tamaddon ◽  
Henrik Andersson ◽  
Gustav Torisson ◽  
Gustav Mårtensson ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
Clinical Experience ◽  
Medial Temporal Lobe ◽  
Ordinal Data ◽  
Rating Scale ◽  
True Positive ◽  
Medial Temporal Lobe Atrophy ◽  
Similar Accuracy ◽  
Lobe Atrophy ◽  
Adequate Agreement

Abstract Objectives To assess inter-modality agreement and accuracy for medial temporal lobe atrophy (MTA) ratings across radiologists with varying clinical experience in a non-demented population. Methods Four raters (two junior radiologists and two senior neuroradiologists) rated MTA on CT and MRI scans using Scheltens’ MTA scale. Ratings were compared to a consensus rating by two experienced neuroradiologists for estimation of true positive and negative rates (TPR and TNR) and over- and underestimation of MTA. Inter-modality agreement expressed as Cohen’s κ (dichotomized data), Cohen’s κw, and two-way mixed, single measures, consistency ICC (ordinal data) were determined. Adequate agreement was defined as κ/κw ≥ 0.80 and ICC ≥ 0.80 (significance level at 95% CI ≥ 0.65). Results Forty-nine subjects (median age 72 years, 27% abnormal MTA) with cognitive impairment were included. Only junior radiologists achieved adequate agreement expressed as Cohen’s κ. All raters achieved adequate agreement expressed as Cohen’s κw and ICC. True positive rates varied from 69 to 100% and TNR varied from 85 to 100%. No under- or overestimation of MTA was observed. Ratings did not differ between radiologists. Conclusion We conclude that radiologists with varying experience achieve adequate inter-modality agreement and similar accuracy when Scheltens’ MTA scale is used to rate MTA on a non-demented population. However, TPR varied between radiologists which could be attributed to rating style differences. Key Points • Radiologists with varying experience achieve adequate inter-modality agreement with similar accuracy when Scheltens’ MTA scale is used to rate MTA on a non-demented population. • Differences in rating styles might affect accuracy, this was most evident for senior neuroradiologists, and only junior radiologists achieved adequate agreement on dichotomized (abnormal/normal) ratings. • The use of an MTA scale template might compensate for varying clinical experience which could make it applicable for clinical use.

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