scholarly journals Dendritic Spine Abnormalities in Hippocampal CA1 Pyramidal Neurons Underlying Memory Deficits in the SAMP8 Mouse Model of Alzheimer's Disease

2012 ◽  
Vol 32 (1) ◽  
pp. 233-240 ◽  
Author(s):  
Jaume del Valle ◽  
Sergi Bayod ◽  
Antoni Camins ◽  
Carlos Beas-Zárate ◽  
Dulce A. Velázquez-Zamora ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Mouse Model ◽  
Dendritic Spine ◽  
Pyramidal Neurons ◽  
Memory Deficits ◽  
Ca1 Pyramidal Neurons ◽  
Samp8 Mouse ◽  
Model Of Alzheimer’S Disease ◽  
Hippocampal Ca1 ◽  
Spine Abnormalities

SPINGOSINE-1-PHOSPHATE RECEPTOR 5 AGONIST α-971432 IMPROVES LEARNING AND MEMORY IN THE SAMP8 MOUSE MODEL OF ALZHEIMER’S DISEASE

2017 ◽  
Vol 13 (7) ◽  
pp. P949
Author(s):  
Susan A. Farr ◽  
Elizabeth Louise van der Kam ◽  
Jordan W. Brown ◽  
Michael L. Niehoff ◽  
John E. Morley
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Learning And Memory ◽  
Samp8 Mouse ◽  
Model Of Alzheimer’S Disease

scholarly journals Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Ke Hou ◽  
Jing Zhao ◽  
Hui Wang ◽  
Bin Li ◽  
Kexin Li ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gold Nanoparticles ◽  
Mouse Model ◽  
Chiral Recognition ◽  
Memory Deficits ◽  
Aβ Peptides ◽  
Promising Strategy ◽  
Model Of Alzheimer’S Disease ◽  
Behavioral Impairments

Abstract Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of Aβ42 and cross the blood-brain barrier (BBB) following intravenous administration without noticeable toxicity. D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairments in AD model mice. This conjugation of a small nanoparticle with chiral recognition moiety provides a potential therapeutic approach for AD.

Altered Function of Hippocampal CA1 Pyramidal Neurons in the rTg4510 Mouse Model of Tauopathy

2014 ◽  
Vol 40 (2) ◽  
pp. 429-442 ◽  
Author(s):  
Nils Ole Dalby ◽  
Christiane Volbracht ◽  
Lone Helboe ◽  
Peter Hjørringaard Larsen ◽  
Henrik Sindal Jensen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Pyramidal Neurons ◽  
Rtg4510 Mouse ◽  
Ca1 Pyramidal Neurons ◽  
Hippocampal Ca1

P3-193: METFORMIN INCREASES PKC AND DECREASES APP AND TAU IN THE SAMP8 MOUSE MODEL OF ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_21) ◽  
pp. P1141-P1141
Author(s):  
John E. Morley ◽  
Michael L. Niehoff ◽  
Elizabeth C. Roesler ◽  
Susan A. Farr
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Samp8 Mouse ◽  
Model Of Alzheimer’S Disease
Sign in / Sign up

Export Citation Format

Share Document