scholarly journals Justification of the use of non-steroidal anti-inflammatory drugs injectable forms

2020 ◽  
Vol 4 (8) ◽  
pp. 518-524
Author(s):  
A.E. Karateev ◽  
Keyword(s):  
Clinical Studies ◽  
Adverse Reactions ◽  
Ease Of Use ◽  
Open Label ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Fast Acting ◽  
Active Substances ◽  
Russian Medical ◽  
Injectable Form

Treatment of acute intense pain requires the use of strong fast-acting analgesics, such as parenteral forms of non-steroidal anti-inflammatory drugs (NSAIDs). Intravenous and intramuscular (i.m.) NSAIDs administration increases the bioavailability of active substances, allows for analgesic therapy in the presence of restrictions for oral administration, and is predominant in the rate of analgesic action onset versus the latter. When choosing NSAIDs for i.m. administration, the risk of topical post-injection and systemic adverse reactions should be considered. Original meloxicam for i.m. injection is characterized by a favorable risk-benefit ratio and ease of use. In clinical studies, there was no significant increase in creatinine phosphokinase levels, reflecting damage to muscle fibers, after a series of injections of meloxicam i.m. versus other NSAIDs, such as diclofenac and piroxicam. During the search in PubMed, Medline, Google, there was no description of serious topical complications after i.m. administration of meloxicam. In recent years, several large open-label studies have been conducted in Russia demonstrating the efficacy and safety of meloxicam injectable form in acute/subacute non-specific back pain and injuries. The review provides a brief description of the main clinical studies concerning the original meloxicam for i.m. injection.KEYWORDS: NSAIDs, meloxicam, intramuscularly, efficacy, safety.FOR CITATION: Karateev A.E. Justification of the use of non-steroidal anti-inflammatory drugs injectable forms. Russian Medical Inquiry. 2020;4(8):518–524. DOI: 10.32364/2587-6821-2020-4-8-518-524.

scholarly journals Efficacy and safety of non-steroidal anti-inflammatory drugs for acute attack of gout

2021 ◽  
Vol 5 (2) ◽  
pp. 96-101
Author(s):  
V.B. Vasilyuk ◽  
◽  
G.I. Syraeva ◽  
M.V. Faraponova ◽  
◽  
...  
Keyword(s):  
Inflammatory Arthritis ◽  
Adverse Reactions ◽  
Acute Attack ◽  
Therapeutic Modality ◽  
Efficacy And Safety ◽  
Nsaid Treatment ◽  
Depth Analysis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Russian Medical

Gout is one of the most common forms of inflammatory arthritis. Medical care for gout includes non-steroidal anti-inflammatory drugs (NSAIDs). This paper reviews the efficacy and safety of NSAIDs prescribed for the acute attack of gout, in particular, AMBENIUM® parenteral. It was demonstrated that phenylbutazone is a powerful NSAID that provides significant analgesic and anti-inflammatory effects. Considering a broad spectrum of adverse reactions of NSAIDs, these agents should be prescribed and used under in-depth analysis of patient’s condition, comorbidities and the level of their decompensation, and potential drug interactions. In addition, optimal dosages and duration of NSAID treatment are of particular importance. The authors conclude that AMBENIUM® parenteral is an effective and safe therapeutic modality for gout. Its profile and risk/benefit ratio are regarded as “favorable” compared to other NSAIDs. KEYWORDS: gout, arthritis, pain, non-steroidal anti-inflammatory drugs, parenteral, efficacy, safety. FOR CITATION: Vasilyuk V.B., Syraeva G.I., Faraponova M.V. Efficacy and safety of non-steroidal anti-inflammatory drugs for acute attack of gout. Russian Medical Inquiry. 2021;5(2):96–101. DOI: 10.32364/2587-6821-2021-5-2-96-101.

Adverse reactions with the use of non-steroidal anti-inflammatory drugs

2020 ◽  
pp. 35-50
Author(s):  
M. L. Maksimov ◽  
N. M. Kiseleva ◽  
D. G. Semenikhin ◽  
B. K. Romanov
Keyword(s):  
Risk Factors ◽  
Adverse Reactions ◽  
Effective Prevention ◽  
Chemical Structures ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Prevention Method ◽  
Effective Medication ◽  
Upper Gastrointestinal

Non-steroidal anti-inflammatory drugs (NSAIDs) are included in a pharmacological group of drugs with different chemical structures providing anti-inflammatory, analgesic and antipyretic actions, as well as antiplatelet action to a certain degree. Unfortunately, NSAIDs can cause a wide range of adverse reactions (AR) posing a serious risk to the health and life of patients. Therefore, the rational use of NSAIDs should include methods for effective prevention of drug complications. Many NSAIDs have a pronounced therapeutic effect, simultaneously causing many undesirable effects, so the drug shall be chosen considering the development of predicted side effects and modern algorithms. According to clinical recommendations, risk factors and administration of safer NSAIDs shall be considered as the main prevention method. Besides, it is possible to protect the patient from the upper gastrointestinal tract complications using proton pump inhibitors. It should be noted that there are no effective medication methods for kidney and liver protection to reduce the risk of NSAID-associated complications.

scholarly journals Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease

2019 ◽  
Vol 40 (4) ◽  
pp. 1080-1091 ◽  
Author(s):  
Marc Y Donath ◽  
Daniel T Meier ◽  
Marianne Böni-Schnetzler
Keyword(s):  
Metabolic Syndrome ◽  
Clinical Studies ◽  
Cell Function ◽  
Therapeutic Interventions ◽  
Metabolic Inflammation ◽  
Inflammatory Conditions ◽  
Β Cell Function ◽  
Associated Conditions ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action and glucose control and may prevent long-term complications. Thus, a number of anti-inflammatory drugs approved for the treatment of other inflammatory conditions are evaluated in patients with metabolic syndrome. Most advanced are clinical studies with IL-1 antagonists showing improved β-cell function and glycemia and prevention of cardiovascular diseases and heart failure. However, alternative anti-inflammatory treatments, alone or in combinations, may turn out to be more effective, depending on genetic predispositions, duration, and manifestation of the disease. Thus, there is a great need for comprehensive and well-designed clinical studies to implement anti-inflammatory drugs in the treatment of patients with metabolic syndrome and its associated conditions.

scholarly journals Anaphylaxis After Ingesting Ibuprofen Liquid Gelatin-Capsule

2012 ◽  
Vol 5 (1) ◽  
pp. 65-67 ◽  
Author(s):  
Fahad Al-Ghimlas ◽  
Nasser Al-Ahmed ◽  
Sean Mace
Keyword(s):  
Skin Test ◽  
Adverse Reactions ◽  
Inflammatory Diseases ◽  
Positive Skin Test ◽  
Gelatin Capsule ◽  
Capsule Formulation ◽  
Positive Skin ◽  
Ige Mediated ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Non-steroidal anti-inflammatory drugs are used daily by millions of patients worldwide for the management of various inflammatory diseases. Many well-documented adverse reactions are related to the use of these drugs. We report a fifty-four year-old woman with anaphylaxis after ingestion of ibuprofen liquid in a gelatin capsule. Eventually this was concluded to have resulted from hypersensitivity to the gelatin component of the capsule, which was likely IgE-mediated because of the positive skin test to gelatin. Gelatin allergy is only relevant for patients ingesting specific capsule formulation. The allergist/clinical immunologist must keep in mind the possibility of gelatin allergy.

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