Coumarin Compound | ScienceGate

The soulatro coumarin compound was isolated and elucidated from the stem bark of Calophyllum soulattri Burm F, the samples were collected from Jayapura Papua Irian Island in Indonesia. Isolation process was done by maceration at room temperature in methanol, than partitioned in a mixture of n hexane-water (1:1), followed by dichloromethane-water (1:1) and ethyl acetate-water (1:1). A portion of ethyl acetate extract was subjected to column chromatography over silica gel packed and eluted with n-hexane a gradient of ethyl acetate to 100% followed by CHCl3 in MeOH (20:1, 10 :1, 5:1, 1:1). Fraction B (CHCl3 in MeOH 20:1) was subjected to column chromatography over silica gel 300 mesh and eluted with EtOAc-MeOH mixtures of increasing polarity. Faction with the same Rf valeus were combined and eluted with EtOAc-MeOH (19:1) showed one spot on TLC. They were combined and evaporated to yield a solid than was recrystallized in mixture of CH2Cl2-methanol to give soulatro coumarin compound. The structure was determinated by spectroscopic analysis, in particular by 1D and 2D NMR techniques, from these spectra data conclution that compound is soulatro coumarin. Antimalarial assay was tested against Plasmodium berghei parasite as in vivo using 18 mices rodent wich was infected by Plasmodium berghei parasite. The soulatro coumarin showed activity against P. berghei with dosage 0.0005867 mM/1 kg body weight ; 0.005867 mM/1 kg bw; 0.05867 mM/1 kg bw; 0.5867 mM/1 kg bw 5.867 mM/1 kg bw and 58.67 mM/1 kg bw could inhibite growth rate of parasite = 57.32%; 63.37%; 43.02%; 53.49%; 47.67% respectively.Keywords : Antiplasmodial activity, coumarin, Calophyllum soulattri Burm. F, in vivo, Chloroquine, Plasmodium berghei.

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Investigation of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H-chromen-2-one as a promising coumarin compound for the development of a new and orally effective antileishmanial agent

Molecular Biology Reports ◽

10.1007/s11033-020-05887-5 ◽

2020 ◽

Vol 47 (11) ◽

pp. 8465-8474

Author(s):

Eduardo de Figueiredo Peloso ◽

Rafaella Junqueira Merli ◽

Patrícia Ferreira Espuri ◽

Juliana Barbosa Nunes ◽

Fábio Antônio Colombo ◽

...

Keyword(s):

Coumarin Compound

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Inhibitory Effect of Osthole from Cnidium monnieri on Tobacco Mosaic Virus (TMV) Infection in Nicotiana glutinosa

Molecules ◽

10.3390/molecules25010065 ◽

2019 ◽

Vol 25 (1) ◽

pp. 65 ◽

Cited By ~ 2

Author(s):

Ya-Han Chen ◽

Dong-Sheng Guo ◽

Mei-Huan Lu ◽

Jian-Ying Yue ◽

Yan Liu ◽

...

Keyword(s):

Coat Protein ◽

Tobacco Mosaic Virus ◽

Mosaic Virus ◽

Plant Virus ◽

Inhibitory Effect ◽

Nicotiana Glutinosa ◽

1H And 13C Nmr ◽

Virus Activity ◽

Viral Particles ◽

Coumarin Compound

The coumarin compound of osthole was extracted from Cnidium monnieri and identified by LC-MS and 1H- and 13C-NMR. Osthole was tested for anti-virus activity against tobacco mosaic virus (TMV) using the half-leaf method. The results showed that stronger antiviral activity on TMV infection appeared in Nicotiana glutinosa than that of eugenol and ningnanmycin, with inhibitory, protective, and curative effects of 72.57%, 70.26%, and 61.97%, respectively. Through observation of the TMV particles, we found that osthole could directly affect the viral particles. Correspondingly, the level of coat protein detected by Western blot was significantly reduced when the concentrations of osthole increased in tested plants compared to that of the control. These results suggest that osthole has anti-TMV activity and may be used as a biological reagent to control the plant virus in the half-leaf method.

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Synthesis of a Coumarin Compound from Phenanthrene by a TiO2-Photocatalyzed Reaction.

ChemInform ◽

10.1002/chin.200646172 ◽

2006 ◽

Vol 37 (46) ◽

Author(s):

Suguru Higashida ◽

Aiko Harada ◽

Rikako Kawakatsu ◽

Noriko Fujiwara ◽

Michio Matsumura

Keyword(s):

Coumarin Compound

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KUALITAS SILASE DAUN GAMAL DENGAN PENAMBAHAN MOLASES SEBAGAI ZAT ADITIF

Indonesian Journal of Applied Sciences ◽

10.24198/ijas.v7i2.13737 ◽

2017 ◽

Vol 7 (2) ◽

Author(s):

Ervi Herawati ◽

Mega Royani

Keyword(s):

Lactic Acid ◽

Animal Feed ◽

Ph Value ◽

Gliricidia Sepium ◽

Feed Material ◽

Randomized Design ◽

Coumarin Compound ◽

Optimal Quality ◽

Acid Percentage

AbstrakGamal adalah tanaman leguminosa pohon yang dapat tumbuh dengan cepat namun pemanfaatannya sebagai bahan pakan ternak memiliki palatabilitas yang rendah akibat bau dan rasanya yang menyengat dan pahit, berasal dari senyawa kumarin, sehingga kurang disukai oleh ternak. Salah satu alternatif yang dapat digunakan untuk menghilangkan zat antinutrisi tersebut yaitu dengan cara dibuat silase. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan molasses terhadap kualitas silase pada daun gamal terfermentasi yang memberikan hasil silase terbaik. Uji kualitas yang diukur adalah pH, persentase asam laktat, dan kadar amonia. Metode penelitian yang digunakan adalah metode eksperimental dengan metode Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 4 ulangan. Perlakuannya terdiri dari penambahan molasses pada daun gamal yaitu P1=1%, P2=2%, P3=3%, P4=4%, dan P5=5%. Hasil pengujian menunjukkan bahwa kualitas silase daun gamal yang optimal didapat pada perlakuan 4 (P4=4% molasses) yang menghasilkan rata-rata nilai pH sebesar 4,18, persentase asam laktat 1,143%, dan kadar NH3 sebesar 6,06 mM. Kata kunci: asam laktat, gamal, molases, NH3, pH. AbstractGliricidia sepium is a leguminous tree that grows rapidly but its use as animal feed material has low palatability due to its stinky smell and bitter taste, caused by coumarin compound, hence it is less favored by livestock. One alternative way to remove this compound is by making silage. This study was aimed to determine the effect of adding molasses to the quality of silage on fermented Gliricidia sepium leaves to obtain the best silage result. Quality tests measured include pH, lactic acid percentage, and ammonia levels. Method used was experimental Completely Randomized Design with 5 treatments and 4 replications. The treatment consisted of the addition of molasses on the Gliricidia sepium leaf, P1 = 1%, P2 = 2%, P3 = 3%, P4 = 4%, and P5 = 5%. Results showed that the optimal quality of Gliricidia sepium leaf silage was obtained from P4 (4% molasses) which resulted in average pH value of 4.18, lactic acid percentage 1.143%, and NH3 level of 6.06 mM.Keywords: lactic acid, Gliricidia sepium, molasses, NH3, pH.

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