TYR Gene | ScienceGate

In Saccharomyces cerevisiae, pseudouridine formation in the middle position of the tRNA(Tyr) anticodon (psi 35) is dependent on the presence of the intron in the tRNA(Tyr) gene (Johnson and Abelson, Nature 302:681-687, 1983). Drosophila melanogaster tRNA(Tyr) genes contain introns of three size classes: 20 or 21 base pairs (bp) (six genes), 48 bp (one gene), and 113 bp (one gene). As in yeast, removal of the intron led to loss of psi 35 in the anticodon when transcription was assayed in Xenopus laevis oocytes. All Drosophila intron sizes supported psi 35 formation. The same results were obtained with the homologous X. laevis tRNA(Tyr) genes containing introns of 12 or 13 bp or with a deleted intron. The introns of yeast (Nishikura and DeRobertis, J. Mol. Biol. 145:405-420, 1981), D. melanogaster, and X. laevis tRNA(Tyr) wild-type genes, while they all supported psi 35 synthesis, did not share any consensus sequences. As discussed, these results, taken together, suggest that for appropriate function the psi 35 enzyme in the X. laevis oocyte needs the presence of an unqualified intron in the tRNA gene and a tRNA(Tyr)-like structure in the unprocessed tRNA precursor.

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A new sand frog from Namaqualand, South Africa (Pyxicephalidae: Tomopterna)

Zootaxa ◽

10.11646/zootaxa.4609.2.2 ◽

2019 ◽

Vol 4609 (2) ◽

pp. 225

Author(s):

LYLE WILSON ◽

ALAN CHANNING

Keyword(s):

South Africa ◽

New Species ◽

16S Rrna ◽

Advertisement Call ◽

Rrna Sequence ◽

16S Rrna Sequence ◽

Adult Morphology ◽

Haplotype Networks ◽

Tyr Gene

Tomopterna branchi sp. nov. is described from Namaqualand, South Africa. It differs from all other Tomopterna species by advertisement call, 16S rRNA sequence and consistent differences in adult morphology. The tadpole is similar to that of Tomopterna cryptotis. Haplotype networks of 16S and the nuclear tyr gene show that it is distinct from T. delalandii, with which it has been confused. A phylogeny of the genus, excluding the little-known T. monticola, shows that the new species is basal to a clade that includes T. delalandii and six other species. We extend the known range of T. damarensis to southern Namibia, and correct the identification of some GenBank material.

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One-allele system in the Korean for MboI-RFLP in exon 1 of the human tyrosinase (TYR) gene

Journal of Dermatological Science ◽

10.1016/s0923-1811(00)00075-x ◽

2000 ◽

Vol 24 (1) ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Dae-Kwang Kim ◽

Kyung-Hee Kang ◽

In-Jang Choi

Keyword(s):

Exon 1 ◽

Tyr Gene ◽

Human Tyrosinase

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Potential Founder Effect of Tyrosinase Gene Mutations in Oculocutaneous Albinism Families from West of Iran

Journal of Human Genetics and Genomics ◽

10.5812/jhgg.63718 ◽

2017 ◽

Vol 1 (1) ◽

Author(s):

Faravareh Khordadpoor Deilamani ◽

Mohammad Taghi Akbari

Keyword(s):

Founder Effect ◽

Gene Mutations ◽

Homozygosity Mapping ◽

Oculocutaneous Albinism ◽

Founder Mutations ◽

Single Base ◽

Str Markers ◽

Tyrosinase Gene ◽

Similar Haplotype ◽

Tyr Gene

Background: Non syndromic oculocutaneous albinism type (OCA) is caused by mutations in tyrosinase (TYR), OCA2, TYRP1, MATP (SLC45A2), SLC24A5 and C10ORF11 genes. Screening for mutations is important in families with oculocutaneous albinism patients in order to accurately diagnose the albinism type, genetic counseling and future therapeutic purposes. Objectives: The Aim of this study was to investigate the founder effect of most frequent mutations in OCA patients. Methods: TYR gene was sequenced in 26 unrelated inbred OCA families as well as 56 unrelated healthy individuals. In addition, homozygosity mapping was performed using 13 STR markers for 6 OCA loci (TYR, OCA2, TYRP1, MATP (SLC45A2), SLC24A5 and C10ORF11 genes). Different mutations were found in these genes from which a single base duplication (c.286dupA) and two single base substitutions c.996G > A (p.M332I) and c.230G > A (p.R77Q) had the most frequencies among the OCA families. In order to investigate the founder effect of these mutations, the haplotypes of two STR markers (TYR-S1 and TYR-S2) inside the TYR gene were ascertained. Results: It was revealed that families with similar mutation harbored similar haplotype for the TYR STR markers too. Conclusions: We conclude that these mutations are possible founder mutations in the Iranian population.

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