scholarly journals Treatment Contrast Interaction

2020 ◽  
Author(s):  



1998 ◽  
Vol 111 (1) ◽  
pp. 121-129 ◽  
Author(s):  
R. Rzepecki ◽  
S.S. Bogachev ◽  
E. Kokoza ◽  
N. Stuurman ◽  
P.A. Fisher

A 32P-labeling strategy was developed to study the interaction(s) in tissue culture cells between proteins and nucleic acids. Interphase and mitotic nuclear lamins were studied in Drosophila Kc cells. After bromodeoxyuridine incorporation and in vivo photo-crosslinking with 366 nm light, it was found that interphase lamins were associated with nucleic acid. Interactions with DNA as well as RNA were detected. In contrast, interaction of nucleic acids with mitotic lamin was not observed. Photo-crosslinking in the presence of antibiotics distamycin and/or chromomycin suggested that interphase lamins interacted with both A-T-rich DNA and G-C-rich DNA; interactions with G-C-rich DNA predominated. These results have implications for understanding the interphase organization of the higher eukaryotic cell nucleus as well as the transition of cells from interphase to mitosis. A model of nuclear organization, consistent with our results, is proposed.



2021 ◽  
Author(s):  
Pamela Rose Buckley ◽  
Charles R. Ebersole ◽  
Christine Steeger ◽  
Laura Elizabeth Michaelson ◽  
Karl G. Hill ◽  
...  

Objective. Transparency of research methods is vital to science, though incentives are variable, with only some journals and funders adopting transparency policies. Clearinghouses are also important stakeholders; however, to date none have implemented formal procedures that facilitate transparent research. Using data from the longest standing clearinghouse, we examine transparency practices for preventive interventions to explore the role of online clearinghouses in incentivizing researchers to make their research more transparent. Methods. We conducted a descriptive analysis of 88 evaluation reports reviewed in 2018-19 by Blueprints for Healthy Youth Development, when the clearinghouse began checking for trial registrations, and expanded on these efforts by applying broader transparency standards to interventions eligible for an endorsement on the Blueprints website during the study period. Reports were recent, with 84% published between 2010 and 2019. Results. We found few reports had data, code, or research materials that were publicly available. Meanwhile, 40% had protocols that were registered, but only 8% were registered prospectively, while one-quarter were registered before conducting analyses. About one-third included details in a registered protocol describing the treatment contrast and planned inclusions, and less than 5% had a registered statistical analysis plan (e.g., planned analytical methods, pre-specified covariates, etc.). Confirmatory research was distinguished from exploratory work in roughly 40% of reports. Reports published more recently (after 2015) had higher rates of transparency. Conclusions. Preventive intervention research needs to be more transparent. Since clearinghouses rely on robust findings to make well-informed decisions and researchers are incentivized to meet clearinghouse standards, clearinghouses should consider policies that encourage transparency to improve the credibility of evidence-based interventions.



2011 ◽  
Vol 36 (9) ◽  
pp. 1614 ◽  
Author(s):  
Yukio Hayashi ◽  
Alexander S. Pirozhkov ◽  
Masaki Kando ◽  
Yuji Fukuda ◽  
Anatoly Faenov ◽  
...  


2016 ◽  
Vol 31 (2) ◽  
pp. 107-121 ◽  
Author(s):  
Janne M. Veerbeek ◽  
Anneli C. Langbroek-Amersfoort ◽  
Erwin E. H. van Wegen ◽  
Carel G. M. Meskers ◽  
Gert Kwakkel

Background. Robot technology for poststroke rehabilitation is developing rapidly. A number of new randomized controlled trials (RCTs) have investigated the effects of robot-assisted therapy for the paretic upper limb (RT-UL). Objective. To systematically review the effects of poststroke RT-UL on measures of motor control of the paretic arm, muscle strength and tone, upper limb capacity, and basic activities of daily living (ADL) in comparison with nonrobotic treatment. Methods. Relevant RCTs were identified in electronic searches. Meta-analyses were performed for measures of motor control (eg, Fugl-Meyer Assessment of the arm; FMA arm), muscle strength and tone, upper limb capacity, and basic ADL. Subgroup analyses were applied for the number of joints involved, robot type, timing poststroke, and treatment contrast. Results. Forty-four RCTs (N = 1362) were included. No serious adverse events were reported. Meta-analyses of 38 trials (N = 1206) showed significant but small improvements in motor control (~2 points FMA arm) and muscle strength of the paretic arm and a negative effect on muscle tone. No effects were found for upper limb capacity and basic ADL. Shoulder/elbow robotics showed small but significant effects on motor control and muscle strength, while elbow/wrist robotics had small but significant effects on motor control. Conclusions. RT-UL allows patients to increase the number of repetitions and hence intensity of practice poststroke, and appears to be a safe therapy. Effects on motor control are small and specific to the joints targeted by RT-UL, whereas no generalization is found to improvements in upper limb capacity. The impact of RT-UL started in the first weeks poststroke remains unclear. These limited findings could mainly be related to poor understanding of robot-induced motor learning as well as inadequate designing of RT-UL trials, by not applying an appropriate selection of stroke patients with a potential to recovery at baseline as well as the lack of fixed timing of baseline assessments and using an insufficient treatment contrast early poststroke.



2021 ◽  
Vol 38 (1) ◽  
pp. 10
Author(s):  
Simon Croxson ◽  
Iara Sequeiros


Author(s):  
J Lawrence ◽  
L Li

Interaction of CO2, Nd:YAG, excimer and high-power diode laser (HPDL) radiation with the surface of the biomaterial polyethylene (PE), was found to effect varying degrees of change to the wettability characteristics of the material depending upon the laser used. It was observed that interaction with CO2, Nd:YAG and HPDL effected very little change to the wettability characteristics of the PE. In contrast, interaction of the PE with excimer laser radiation resulted in a marked improvement in the wettability characteristics. After excimer laser treatment, the surface O2 content was found to have increased and the material was seen to be more polar in nature, resulting in a significant increase in the wettability characteristics. The work has shown that the wettability characteristics of the PE could be controlled and/or modified with laser surface treatment. However, a wavelength dependence of the change in the wetting properties could not be deduced from the findings of this work.





1993 ◽  
Vol 9 (2) ◽  
pp. 143-148 ◽  
Author(s):  
Duane Knudson

The rebound accuracy of tennis impacts was studied by measuring the vertical angles of approach and rebound of tennis balls projected in a vertical plane at a clamped racket. Three identical oversized tennis rackets were strung with nylon at 200, 267, and 334 N of tension. Ten impacts were filmed at 200 Hz for each string tension with the ball impacting the strings centrally and 8 cm off-center. A two-way ANOVA revealed significant (p < .01) main effects for string tension, impact location, and the interaction of string tension and impact location. Treatment-Contrast Interactions demonstrated one significant (p < .01) difference: The decrease in rebound accuracy from a string tension of 200 to 334 N was significantly different for central versus off-center impacts.



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